Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Silveira MAD, Bilodeau S, Greten TF, Wang XW, Trinchieri G

The gut-liver axis: host microbiota interactions shape hepatocarcinogenesis

Journal Article

Trends Cancer, 8 (7), 2022.

Abstract | Links:

Boibessot C, Molina O, Lachance G, Tav C, Champagne A, Neveu B, Pelletier JF, Pouliot F, Fradet V, Bilodeau S, Fradet Y, Bergeron A, Toren P

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype

Journal Article

Clin Transl Med, 12 (1), 2022.

Abstract | Links:

Mangnier L, Joly-Beauparlant C, Droit A, Bilodeau S, Bureau A

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia

Journal Article

Life Sci Alliance, 5 (5), 2022.

Abstract | Links:

Bilodeau S, Kurat CF, Lambert JP

Editorial: The Evolving Chromatin and Transcriptional Landscapes-Emerging Methods, Tools and Techniques

Journal Article

Front Cell Dev Biol, 9 , 2021.

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Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, Caron D, Bérubé JS, Bérubé JC, Coulombe Y, Orain M, Gélinas Y, Gobeil S, Bossé Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M

ZNF768 links oncogenic RAS to cellular senescence

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Silveira MA, Tav C, Bérube-Simard FA, Cuppens T, Leclercq M, Fournier É, Côté MC, Droit A, Bilodeau S

Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

Journal Article

Life Sci Alliance, 4 (5), 2021.

Abstract | Links:

Vélot L, Lessard F, Bérubé-Simard FA, Tav C, Neveu B, Teyssier V, Boudaoud I, Dionne U, Lavoie N, Bilodeau S, Pouliot F, Bisson N

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner

Journal Article

Mol Cell Proteomics, 20 , 2021.

Abstract | Links:

Al Dow M, Silveira MAD, Poliquin A, Tribouillard L, Fournier É, Trébaol E, Secco B, Villot R, Tremblay F, Bilodeau S, Laplante M

Control of adipogenic commitment by a STAT3-VSTM2A axis

Journal Article

Am J Physiol Endocrinol Metab, 320 (2), 2021.

Abstract | Links:

Silveira MAD, Bilodeau S

Defining the Transcriptional Ecosystem

Journal Article

Mol Cell, 72 (6), 2018.

Abstract | Links:

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA

Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Journal Article

Nature, 562 (7728), 2018.

Abstract | Links:

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Active projects

  • Chaire de recherche du Canada en génomique transcriptionnelle, from 2017-09-01 to 2022-08-31
  • Defining the global transcriptional response to perturbations, from 2021-04-01 to 2026-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response, from 2021-09-01 to 2023-08-31
  • Toward defining the transcriptional ecosystem, from 2019-04-01 to 2024-03-31
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2023-01-14

Recently finished projects

  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), from 2020-03-01 to 2021-02-28
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, from 2017-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery