Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Kumar A, Schwab M, Laborit Labrada B, Silveira MAD, Goudreault M, Fournier É, Bellmann K, Beauchemin N, Gingras AC, Bilodeau S, Laplante M, Marette A

SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis

Journal Article

J Biol Chem, 299 (9), 2023.

Abstract | Links:

Tav C, Fournier É, Fournier M, Khadangi F, Baguette A, Côté MC, Silveira MAD, Bérubé-Simard FA, Bourque G, Droit A, Bilodeau S

Glucocorticoid stimulation induces regionalized gene responses within topologically associating domains

Journal Article

Front Genet, 14 , 2023.

Abstract | Links:

Silveira MAD, Khadangi F, Mersaoui SY, Naik D, Masson JY, Bilodeau S

HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways

Journal Article

J Biol Chem, 299 (2), 2023.

Abstract | Links:

Bouirdene S, Leclercq M, Quitté L, Bilodeau S, Droit A

BioDiscViz: A visualization support and consensus signature selector for BioDiscML results

Journal Article

PLoS One, 18 (11), 2023.

Abstract | Links:

Mangnier L, Joly-Beauparlant C, Droit A, Bilodeau S, Bureau A

Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia

Journal Article

Life Sci Alliance, 5 (5), 2022.

Abstract | Links:

Boibessot C, Molina O, Lachance G, Tav C, Champagne A, Neveu B, Pelletier JF, Pouliot F, Fradet V, Bilodeau S, Fradet Y, Bergeron A, Toren P

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype

Journal Article

Clin Transl Med, 12 (1), 2022.

Abstract | Links:

Silveira MAD, Bilodeau S, Greten TF, Wang XW, Trinchieri G

The gut-liver axis: host microbiota interactions shape hepatocarcinogenesis

Journal Article

Trends Cancer, 8 (7), 2022.

Abstract | Links:

Bilodeau S, Kurat CF, Lambert JP

Editorial: The Evolving Chromatin and Transcriptional Landscapes-Emerging Methods, Tools and Techniques

Journal Article

Front Cell Dev Biol, 9 , 2021.

| Links:

Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, Caron D, Bérubé JS, Bérubé JC, Coulombe Y, Orain M, Gélinas Y, Gobeil S, Bossé Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M

ZNF768 links oncogenic RAS to cellular senescence

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Silveira MA, Tav C, Bérube-Simard FA, Cuppens T, Leclercq M, Fournier É, Côté MC, Droit A, Bilodeau S

Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

Journal Article

Life Sci Alliance, 4 (5), 2021.

Abstract | Links:

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Active projects

  • Defining the global transcriptional response to perturbations, from 2021-04-01 to 2026-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Toward defining the transcriptional ecosystem, from 2019-04-01 to 2025-03-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2025-03-31

Recently finished projects

  • Canadian Epigenetics, Environment and Health Research Consortium Network Phase II, from 2019-07-01 to 2023-06-30
  • Chaire de recherche du Canada en génomique transcriptionnelle, from 2017-09-01 to 2022-08-31
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response, from 2021-09-01 to 2023-08-31
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
Data provided by the Université Laval research projects registery