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Barbara Papadopoulou

Formation
B. Pharm

Ph.D.

FCAHS

Professeure, département de microbiologie-infectiologie et d'immunologie, Université Laval

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Principal area
Infectious and immune diseases
Address
Centre Hospitalier de l'Université Laval (CHUL)
2705, boulevard Laurier, RC-709
Québec (Québec)
CANADA G1V 4G2

Phone
+1 418-525-4444, poste 47608
Fax
+1 418-654-2715
Email
barbara.papadopoulou@crchudequebec.ulaval.ca

Dr. Barbara Papadopoulou, B. Pharm., Ph.D., is a full professor in the Department of microbiology-infectious diseases and immunology of the Faculty of medicine at Université Laval. She received her Ph.D. degree in microbiology and molecular biology from the University of Paris XI and Pasteur Institute of Paris in France. For her postdoctoral studies, she was trained in yeast genetics at the University of Amsterdam and on Leishmania molecular biology and drug resistance at Laval University. Dr. Papadopoulou is a world expert on Leishmania parasitic diseases and her research focus is on gene regulation, microbial pathogenesis, functional genomics and vaccinology. Her group uses a combination of molecular, genomics and proteomics approaches to identify developmentally expressed genes/proteins, delineate the molecular mechanisms underlying their stage-specific regulation and assess their potential function in the intracellular survival of the parasite and in disease development. Her group is also interested in the development of novel vaccine strategies against Leishmania. She is the author of more than 120 peer-reviewed publications, several reviews and book chapters, and more than 215 communications in international meetings and symposia.

 

Dr. Papadopoulou is a Fellow of the Canadian Academy of Health Sciences and has received several other prestigious national and international awards for excellence in research, including a Medical Research Council Scholar Award and the New Investigator Award in Molecular Parasitology from the Burroughs Wellcome Fund for her outstanding and original contributions in the field of parasitic diseases. She is currently the Director of the Division of Infectious Disease and Immunology of the CHU de Quebec Research Center and a member of several provincial and national strategic initiatives on host-parasite interactions (FQRNT) and international consortiums (Worldleish and TriTrypDB, a functional genomic resource for the Trypanosomatidae). She is a member of the Board of Directors of the Fonds de Recherche du Québec-Santé (FRQS) and the FRQS Governing Council. She serves on the editorial board of scientific journals in the field of parasitology and on peer review panels of several national and international funding agencies for academia and the government.

Research team

Research professionnal:

Carole Dumas

Postdoctoral trainee:

Karen Charet

Aurélien Dupé

Ouafa Zghidi-Abouzid

Ph.D.student:

Azizi Hiva

Recent publications (see all publication from this researcher)

Ann J, Samant M, Rheaume C, Dumas C, Beaulieu E, Morasse A, Mallett C, Hamelin ME, Papadopoulou B, Boivin G. Adjuvanted inactivated influenza A(H3N2) vaccines induce stronger immunogenicity in mice and confer higher protection in ferrets than unadjuvanted inactivated vaccines. Vaccine,  2014. Epub
Zahedifard F, Gholami E, Taheri T, Taslimi Y, Doustdari F, Seyed N, Torkashvand F, Meneses C, Papadopoulou B, Kamhawi S, Valenzuela JG, Rafati S. Enhanced protective efficacy of nonpathogenic recombinant leishmania tarentolae expressing cysteine proteinases combined with a sand fly salivary antigen. PLoS neglected tropical diseases,  2014. 8: e2751
Ubeda JM, Raymond F, Mukherjee A, Plourde M, Gingras H, Roy G, Lapointe A, Leprohon P, Papadopoulou B, Corbeil J, Ouellette M. Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania. PLoS biology,  2014. 12: e1001868
Dupe A, Dumas C, Papadopoulou B. An Alba-domain protein contributes to the stage-regulated stability of amastin transcripts in Leishmania. Molecular microbiology,  2014. 91: 548-61
Saljoughian N, Taheri T, Zahedifard F, Taslimi Y, Doustdari F, Bolhassani A, Doroud D, Azizi H, Heidari K, Vasei M, Namvar Asl N, Papadopoulou B, Rafati S. Development of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasis. PLoS neglected tropical diseases,  2013. 7: e2174
Saljoughian N, Zahedifard F, Doroud D, Doustdari F, Vasei M, Papadopoulou B, Rafati S. Cationic solid-lipid nanoparticles are as efficient as electroporation in DNA vaccination against visceral leishmaniasis in mice. Parasite immunology,  2013. 35: 397-408
Cloutier S, Laverdiere M, Chou MN, Boilard N, Chow C, Papadopoulou B. Translational Control through eIF2alpha Phosphorylation during the Leishmania Differentiation Process. PLoS ONE,  2012. 7: e35085
Baz M, Samant M, Zekki H, Tribout-Jover P, Plante M, Lanteigne AM, Hamelin ME, Mallett C, Papadopoulou B, Boivin G. Effects of different adjuvants in the context of intramuscular and intranasal routes on humoral and cellular immune responses induced by detergent-split A/H3N2 influenza vaccines in mice. Clinical and vaccine immunology : CVI,  2012. 19: 209-18
Brotherton MC, Racine G, Ahmed Ouameur A, Leprohon P, Papadopoulou B, Ouellette M. Analysis of Membrane-Enriched and High Molecular Weight Proteins in Leishmania infantum Promastigotes and Axenic Amastigotes. Journal of proteome research,  2012. 11: 3974-85
Padmanabhan PK, Samant M, Cloutier S, Simard MJ, Papadopoulou B. Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania. Cell death and differentiation,  2012. 19: 1972-82
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