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Barbara Papadopoulou

B. Pharm



Professeure, département de microbiologie-infectiologie et d'immunologie, Université Laval

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Principal area
Infectious and immune diseases
Centre Hospitalier de l'Université Laval (CHUL)
2705, boulevard Laurier, RC-709
Québec (Québec)

+1 418-525-4444, poste 47608
+1 418-654-2715

Dr. Barbara Papadopoulou, B. Pharm., Ph.D., is a full professor in the Department of microbiology-infectious diseases and immunology of the Faculty of medicine at Université Laval. She received her Ph.D. degree in microbiology and molecular biology from the University of Paris XI and Pasteur Institute of Paris in France. For her postdoctoral studies, she was trained in yeast genetics at the University of Amsterdam and on Leishmania molecular biology and drug resistance at Laval University. Dr. Papadopoulou is a world expert on Leishmania parasitic diseases and her research focus is on gene regulation, microbial pathogenesis, functional genomics and vaccinology. Her group uses a combination of molecular, genomics and proteomics approaches to identify developmentally expressed genes/proteins, delineate the molecular mechanisms underlying their stage-specific regulation and assess their potential function in the intracellular survival of the parasite and in disease development. Her group is also interested in the development of novel vaccine strategies against LeishmaniaShe is the author of more than 120 peer-reviewed publications, several reviews and book chapters, and more than 215 communications in international meetings and symposia. 



Dr. Papadopoulou is a Fellow of the Canadian Academy of Health Sciences and has received several other prestigious national and international awards for excellence in research, including a Medical Research Council Scholar Award and the New Investigator Award in Molecular Parasitology from the Burroughs Wellcome Fund for her outstanding and original contributions in the field of parasitic diseases. She is currently the Director of the Division of Infectious Disease and Immunology of the CHU de Quebec Research Center and a member of several provincial and national strategic initiatives on host-parasite interactions (FQRNT) and international consortiums (Worldleish and TriTrypDB, a functional genomic resource for the Trypanosomatidae). She is a member of the Board of Directors of the Fonds de Recherche du Québec-Santé (FRQS) and the FRQS Governing Council. She serves on the editorial board of scientific journals in the field of parasitology and on peer review panels of several national and international funding agencies for academia and the government. 

Research team

Research professionnal:

Carole Dumas

Postdoctoral trainee:

Karen Charet

Aurélien Dupé

Ouafa Zghidi-Abouzid


Azizi Hiva

Recent publications (see all publication from this researcher)

Dupe A, Dumas C, Papadopoulou B. Differential Subcellular Localization of Leishmania Alba-Domain Proteins throughout the Parasite Development. PLoS ONE,  2015. 10: e0137243
Shahbazi M, Zahedifard F, Saljoughian N, Doroud D, Jamshidi S, Mahdavi N, Shirian S, Daneshbod Y, Hamid Zarkesh-Esfahani S, Papadopoulou B, Rafati S. Immunological comparison of DNA vaccination using two delivery systems against canine leishmaniasis. Veterinary parasitology,  2015. Epub
Katebi A, Gholami E, Taheri T, Zahedifard F, Habibzadeh S, Taslimi Y, Shokri F, Papadopoulou B, Kamhawi S, Valenzuela JG, Rafati S. Leishmania tarentolae secreting the sand fly salivary antigen PpSP15 confers protection against Leishmania major infection in a susceptible BALB/c mice model. Molecular immunology,  2015. 67: 501-11
Shahbazi M, Zahedifard F, Taheri T, Taslimi Y, Jamshidi S, Shirian S, Mahdavi N, Hassankhani M, Daneshbod Y, Zarkesh-Esfahani SH, Papadopoulou B, Rafati S. Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis. PLoS ONE,  2015. 10: e0132794
Mandal G, Mandal S, Sharma M, Charret KS, Papadopoulou B, Bhattacharjee H, Mukhopadhyay R. Species-specific antimonial sensitivity in Leishmania is driven by post-transcriptional regulation of AQP1. PLoS neglected tropical diseases,  2015. 9: e0003500
de Melo Neto OP, da Costa Lima TD, Xavier CC, Nascimento LM, Romao TP, Assis LA, Pereira MM, Reis CR, Papadopoulou B. The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation. RNA biology,  2015. 12: 1209-21
Papadopoulou B, Muller-McNicoll M, Padmanabhan PK. Approaches for studying mRNA decay mediated by SIDER2 retroposons in Leishmania. Methods in molecular biology (Clifton, N.J.) ,  2015. 1201: 123-42
Ferreira TR, Alves-Ferreira EV, Defina TP, Walrad P, Papadopoulou B, Cruz AK. Altered expression of an RBP-associated arginine methyltransferase 7 in Leishmania major affects parasite infection. Molecular microbiology,  2014. Epub
Ann J, Samant M, Rheaume C, Dumas C, Beaulieu E, Morasse A, Mallett C, Hamelin ME, Papadopoulou B, Boivin G. Adjuvanted inactivated influenza A(H3N2) vaccines induce stronger immunogenicity in mice and confer higher protection in ferrets than unadjuvanted inactivated vaccines. Vaccine,  2014. 32: 5730-9
Dupe A, Dumas C, Papadopoulou B. An Alba-domain protein contributes to the stage-regulated stability of amastin transcripts in Leishmania. Molecular microbiology,  2014. 91: 548-61
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