
Martin Simard
Chercheur universitaire
Axe Oncologie
Full professor
Department of Molecular Biology, Medical Biochemistry, and Pathology
Faculty of Medicine
Professor Martin Simard obtained his doctorate in microbiology (with a specialty in molecular biology) from the Université de Sherbrooke and pursued postdoctoral studies in molecular genetics with Dr. Craig Mello at the University of Massachusetts Medical School. During this pivotal period in understanding the regulatory role of small non-coding RNAs, his work, in particular, helped develop new strategies to use siRNAs better and determine the function of microRNAs in collaboration with Dr. Philip Zamore’s group.
In 2005, at CHU de Québec-Université Laval Research Center, he established the first research group in Canada interested in this new gene regulation. His research focuses on better understanding how microRNAs contribute to effectively maintaining the proper functioning of our cells and improving our knowledge of RNA interference to use this approach as a therapeutic tool. His group has notably highlighted the presence of different cellular complexes involving microRNAs in animals. His laboratory already has more than fifty research publications to his credit. Over twenty students/trainees have graduated from his laboratory, including some who are currently continuing their scientific training in the largest research institutions and started their own groups.
He was the recipient of the CIHR New Investigator grant and a FRQ-S Research Chair. In 2014, he received the André-Dupont prize from the Club de Recherches Cliniques du Québec, a prize awarded annually to a young researcher for the quality of their achievements in biomedical research. His work benefited from the support of different governmental and private funding agencies.
Team
Vaishnav Vasudevan
Étudiant 3e cycle
HEJ
2260, boulevard Henri BourassaL3.108
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 16949 vaishnav.vasudevan@crchudequebec.ulaval.ca
Émilie Bouchard Dostie
Employée
HEJ
2260, boulevard Henri BourassaL1.129
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 15543 emilie.bouchard-dostie@crchudequebec.ulaval.ca
Émilie Bouchard Dostie
Employée
HEJ
2260, boulevard Henri BourassaL1.129
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 15543 emilie.bouchard-dostie@crchudequebec.ulaval.ca
Pauline Adjibade
Employée
HEJ
2260, boulevard Henri BourassaL3.119
Québec, QC
Canada G1J 1Z4 +1 418 525-4195 +1 418 525-4444, poste 15586 pauline.adjibade.1@crchudequebec.ulaval.ca pauline.adjibade.1@ulaval.ca
Louis-Mathieu Harvey
Étudiant 3e cycle
HEJ
9 Rue Mcmahon0744
Ville de Québec, QC
Canada G1R 3S3 +1 418 525-4444, poste 16949 louis-mathieu.harvey@crchudequebec.ulaval.ca
Anne-Marie Pulichino
Employée
HEJ
2260, boulevard Henri BourassaL1.133
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 67753 Anne-Marie.Pulichino@crchudequebec.ulaval.ca
Jade Beaudoin-Fredette
Étudiante 2e cycle
HEJ
9 rue McMahon0744-2
Québec, QC
Canada G1R 3S3 +1 418 525-4444, poste 16949 jade.beaudoin-fredette.1@ulaval.ca jade.beaudoin-fredette@crchudequebec.ulaval.ca
Pauline Adjibade
Employée
HEJ
2260, boulevard Henri BourassaL3.119
Québec, QC
Canada G1J 1Z4 +1 418 525-4195 +1 418 525-4444, poste 15586 pauline.adjibade.1@crchudequebec.ulaval.ca pauline.adjibade.1@ulaval.ca
François Houle
Employé
HEJ
2260, boulevard Henri BourassaL3.108
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 67884 +1 418 691-5439 Francois.Houle@crchudequebec.ulaval.ca
Pierre-Marc Frédérick
Étudiant 3e cycle
Hors CHU
2260, boulevard Henri BourassaL3.108
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 16949 pierre-marc.frederick.1@ulaval.ca pierre-marc.frederick@crchudequebec.ulaval.ca
Mathieu Segonds
Étudiant 3e cycle
Carl St-Pierre
Employé
HEJ
2260, boulevard Henri BourassaL2.232
Québec, QC
Canada G1J 1Z4 +1 418 525-4444, poste 15408 +1 418 691-5439 carl.st-pierre@crchudequebec.ulaval.ca
Publications
View all-
article Harvey LM, Frédérick PM, Gudipati RK, Michaud P, Houle F, Young D, Desbiens C, Ladouceur S, Dufour A, Großhans H, Simard MJ
Dipeptidyl peptidase DPF-3 is a gatekeeper of microRNA Argonaute compensation in animals
Nat Commun 16 (1), 2025.
-
article Pal A, Vasudevan V, Houle F, Lantin M, Maniates KA, Huberdeau MQ, Abbott AL, Simard MJ
Defining the contribution of microRNA-specific Argonautes with slicer capability in animals
Nucleic Acids Res 52 (9), 2024.
-
article Frédérick PM, Jannot G, Banville I, Simard MJ
Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals
Nucleic Acids Res 52 (11), 2024.
Projects
- Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30
- Deciphering cellular modulators of the microRNA pathway, from 2024-10-01 to 2029-09-30
- Toward understanding the role of tRNA-derived small RNAs in animals, from 2025-04-01 to 2030-03-31
- Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2025-03-31
- Deciphering cellular modulators of the microRNA pathway, from 2023-03-01 to 2024-02-29
- Canadian Developmental Biology Conference, from 2023-01-01 to 2023-12-31