François Gros-Louis

Neurodegenerative diseases and other brain disorders form a subgroup of neurological conditions that typically affect adults, regardless of their socioeconomic background or gender, and whose outcome is generally fatal to a greater or lesser extent in the long term after the onset of symptoms. While Alzheimer’s and Parkinson’s diseases are the most well-known to the general public, there are many others, sometimes more serious, such as Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysms, or even neurofibromatosis (a highly stigmatizing disease). One of the major obstacles to understanding the development of brain diseases is the accessibility of neuronal tissues. Understanding the underlying pathophysiological mechanisms of these diseases is an essential step to help us find new therapeutic strategies, or even cures.

Professor François Gros-Louis Chaire’s research is positioned in a rapidly developing field and will aim to reconstruct biological tissues from patient cells in a three-dimensional (3D) context for experimental and clinical purposes. Another important objective of his research is the development of study models using induced pluripotent stem cells (iPSCs).

The development of novel cellular models derived from patients will enable better study of these diseases and drive research forward, which will have a considerable impact on understanding the underlying pathological mechanisms of these diseases and identifying biomarkers or new therapeutic targets.