David Gosselin
Chercheur universitaire
Axe Neurosciences
Publications
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article Drake SS, Mohammadnia A, Zaman A, Gianfelice C, Heale K, Groh AMR, Hua EM, Hintermayer MA, Lu YR, Gosselin D, Zandee S, Prat A, Stratton JA, Sinclair DA, Fournier AE
Cellular rejuvenation protects neurons from inflammation-mediated cell death
Cell Rep 44 (2), 2025.
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article Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
Nat Immunol 24 (7), 2023.
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article Distéfano-Gagné F, Bitarafan S, Lacroix S, Gosselin D
Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
Nat Rev Neurosci 24 (7), 2023.
Projects
- Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders, from 2021-04-01 to 2026-03-31
- Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
- Enhancing microglial myelin repair mechanisms through stimulation of the Ppar-delta nuclear receptor as a novel therapeutic approach for multiple sclerosis, from 2020-09-01 to 2024-08-31
- Understanding and rejuvenating microglial phagocytosis as mean to inhibit progression of tauopathies in a mouse model of Alzheimer’s Disease, from 2020-10-01 to 2025-09-30
- Étude des mécanismes de la régulation épigénétique et transcriptionnelle responsable des fonctions des microglies, from 2022-01-01 to 2024-08-31
- Étude des mécanismes de la régulation épigénétique et transcriptionelle responsables des fonctions des microglies dans le, from 2023-07-01 to 2025-06-30