Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.
The research
Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the « Spinde Assembly Checkpoint » or « SAC » kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.
Our research focuses on the following questions:
- What are the mechanisms of activation and inactivation of SAC kinases?
- What are the endogenous substrates of SAC kinases?
- Is SAC differentially regulated in cell lines with chromosomal instability?
- How does aneuploidy contribute to cancer?
We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
Latest news
- IRSC : Un financement de près de 16 millions de dollars pour 34 projets de recherche 2023-03-07
- 13 chercheurs du Centre de recherche du CHU de Québec-Université Laval obtiennent 7,6M$ au programme Projet des IRSC 2018-01-26
- 10 chercheurs du Centre de recherche du CHU de Québec se sont mérité une bourse du Fonds Merck-Université Laval 2016-09-16
- Calvo, EvaMaster studentCHUL+1 418-525-4444, extension 42296eva.calvo@crchudequebec.ulaval.caevcal2@ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Devillers, RomainDoctoral studentCHUL+1 418-525-4444, extension 42296romain.devillers@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Dos Santos, AlexsandroDoctoral studentCHUL+1 418-525-4444, extension 42296alexsandro.dos-santos@crchudequebec.ulaval.caalexsandro.santos.1@ulaval.ca
2705, boul. Laurier
T3-67
Québec, Québec
Canada G1V 4G2 - Doucet, ChristianEmployeeCHUL+1 418-525-4444christian.doucet@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3
Québec, QC
Canada G1V 4G2 - Garand, ChantalEmployeeCHUL+1 418-525-4444, extension 42296+1 418-654-2298Chantal.Garand@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2 - Ouellet-Boutin, KatherynDoctoral studentCHUL+1 418-525-4444, extension 42296katheryn.ouellet-boutin.1@ulaval.cakatheryn.ouellet-boutin@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Prifti, DiogjenaDoctoral studentCHUL+1 418-525-4444, extension 42296diogjena.alkaterini-prifti@crchudequebec.ulaval.cadiogjena.prifti.1@ulaval.ca
2705 Boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Saini, Pawan KumarDoctoral studentCHUL+1 418-525-4444, extension 42296pawan-kumar.saini.1@ulaval.capawan.kumar-saini@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2
Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer
Journal ArticleCancers (Basel), 14 (15), 2022.
EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
Journal ArticleCell Rep, 40 (1), 2022.
A commercial ARHGEF17/TEM4 antibody cross-reacts with Nuclear Mitotic Apparatus protein 1 (NuMA)
Journal ArticlePLoS One, 17 (7), 2022.
Considerations for studying phosphorylation of the mitotic checkpoint pseudokinase BUBR1
Journal ArticleMethods Enzymol, 667 , 2022.
The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics
Journal ArticleTrends Biochem Sci, 47 (4), 2022.
ZNF768: controlling cellular senescence and proliferation with ten fingers
Journal ArticleMol Cell Oncol, 8 (6), 2021.
The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release
Journal ArticleFront Immunol, 12 , 2021.
ZNF768 links oncogenic RAS to cellular senescence
Journal ArticleNat Commun, 12 (1), 2021.
Adventures of the undead at kinetochores
Journal ArticleMol Cell Oncol, 8 (2), 2021.
A quantitative and semiautomated method for determining misaligned and lagging chromosomes during mitosis
Journal ArticleMol Biol Cell, 32 (9), 2021.
Active projects
- Exploring A Novel Signalling Pathway in Cilia formation and Ciliopathies, from 2023-02-21 to 2024-02-21
- Functional and evolutionary characterization of the transcription factor ZNF768, from 2023-02-28 to 2024-03-31
- Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
- The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation, from 2023-04-01 to 2028-03-31
Recently finished projects
- Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
- Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2023-03-31
- PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
- Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
- Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2022-03-31