Dr. Eric Boilard, PhD, is a recipient of a CIHR award, Associate Professor in the Department of Microbiology and Immunology at the Laval University School of Medicine, and a researcher at the CHU de Québec Research Center. He is also a researcher with the Canadian National Transplant Research Program (CNTRP), where he is co-leader and consulting member of the international group Systemic Lupus Collaborating Clinics (SLICC).

He obtained his PhD in Microbiology and Immunology from Laval University (2003) and pursued postdoctoral trainings at the Université de Nice-Sophia-Antipolis (2003-2006) and at Harvard University at Brigham and Women’s Hospital (2006-2010). It was during his studies at Harvard that Dr. Boilard highlighted the role of platelets in rheumatoid arthritis (Boilard et al., Science 2010).

His research aims to better understand the pathogenesis of rheumatic diseases, and to improve the success of blood transplants and transfusions to develop new therapeutics and biomarkers. He investigates how platelets and the small extracellular vesicles they produce, called microparticles, contribute to the inflammatory responses in place in rheumatoid arthritis, lupus, and the cases of immune responses involved in transplant rejection and adverse reactions related to transfusions. He conducts clinical research with patients and mouse models of disease.

He is an internationally renowned scientist and lecturer recognized by his peers. He won the Radio-Canada Award for the greatest medical discovery of the year (2011 and 2013), the Radio-Canada and Le Soleil Award of the Scientist of the Year (2011), and is the recipient of the André Dupont Award for Quebec’s most prolific young researcher (2017). His work is in part funded by the CIHR Foundation Program (Platelets and their microparticles: versatile players of inflammation) and NSERC.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
115 entries « 1 of 12 »

Puhm F, Boilard E

Megakaryocytes and platelets embrace diversity in face of adversity

Journal Article

J Thromb Haemost, 2022.

| Links:

Laroche A, Soulet D, Bazin M, Levesque T, Allaeys I, Vallières N, Gunzer M, Flamand L, Lacroix S, Boilard E

Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis

Journal Article

Blood Adv, 6 (12), 2022.

Abstract | Links:

Puhm F, Allaeys I, Lacasse E, Dubuc I, Galipeau Y, Zaid Y, Khalki L, Belleannée C, Durocher Y, Brisson AR, Wolberg AS, Langlois MA, Flamand L, Boilard E

Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells

Journal Article

Blood Adv, 6 (12), 2022.

Abstract | Links:

Hasse S, Julien AS, Duchez AC, Zhao C, Boilard E, Fortin PR, Bourgoin SG

Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus

Journal Article

Lupus Sci Med, 9 (1), 2022.

Abstract | Links:

Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard É, Dieudé M, Hébert MJ

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes

Journal Article

Cell Death Dis, 13 (2), 2022.

Abstract | Links:

Becker YLC, Gagné JP, Julien AS, Lévesque T, Allaeys I, Gougeard N, Rubio V, Boisvert FM, Jean D, Wagner E, Poirier GG, Fortin PR, Boilard É

Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus

Journal Article

Arthritis Rheumatol, 2022.

Abstract | Links:

Miki Y, Taketomi Y, Kidoguchi Y, Yamamoto K, Muramatsu K, Nishito Y, Park J, Hosomi K, Mizuguchi K, Kunisawa J, Soga T, Boilard E, B Gowda SG, Ikeda K, Arita M, Murakami M

Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota

Journal Article

JCI Insight, 7 (2), 2022.

Abstract | Links:

Doré E, Joly-Beauparlant C, Morozumi S, Mathieu A, Lévesque T, Allaeys I, Duchez AC, Cloutier N, Leclercq M, Bodein A, Payré C, Martin C, Petit-Paitel A, Gelb MH, Rangachari M, Murakami M, Davidovic L, Flamand N, Arita M, Lambeau G, Droit A, Boilard E

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation

Journal Article

JCI Insight, 7 (2), 2022.

Abstract | Links:

Puhm F, Flamand L, Boilard E

Platelet extracellular vesicles in COVID-19: Potential markers and makers

Journal Article

J Leukoc Biol, 111 (1), 2022.

Abstract | Links:

Zhao Y, Hasse S, Vaillancourt M, Zhao C, Davis L, Boilard E, Fortin P, Di Battista J, Poubelle PE, Bourgoin SG

Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis

Journal Article

Int J Mol Sci, 22 (23), 2021.

Abstract | Links:

115 entries « 1 of 12 »
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Active projects

  • Contribution of phospholipase A2 enzymes in the homeostasis of the immune system., from 2016-04-01 to 2023-03-31
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy, from 2020-06-01 to 2024-03-31
  • Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury, from 2022-04-01 to 2027-03-31
  • Pathogenic roles of platelets in sepsis, from 2020-03-01 to 2025-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis, from 2020-04-01 to 2025-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis, from 2020-01-01 to 2022-12-31
  • Rôle des plaquettes et de leurs microparticules dans l'inflammation, from 2019-08-01 to 2023-07-31
  • Rôle des plaquettes et des vésicules extracellulaires dans l'inflammation, from 2022-01-01 to 2023-05-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., from 2015-07-01 to 2023-03-31
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project, from 2020-04-01 to 2023-03-31
  • Understanding the pathogenesis of COVID-19, from 2020-03-01 to 2024-03-31

Recently finished projects

  • Computer-Aided Sperm Analysis (CASA) of sperm motility and hyperactivation, from 2021-04-01 to 2022-03-31
  • Mapping anti-mitochondrial antibodies in systemic lupus erythematosus, from 2019-04-01 to 2022-03-31
  • Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern, from 2021-06-01 to 2022-05-31
  • Platelets and their microparticles: versatile players of inflammation., from 2015-07-01 to 2020-06-30
  • Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
  • Role of antibodies in platelet response to SARS-CoV-2 and its variants, from 2021-06-01 to 2022-05-31
  • Role of platelets and their mother cell, the megakaryocyte, in COVID-19, from 2021-03-01 to 2022-02-28
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes, from 2013-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery