The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface. Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases. His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.
Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
- Babou Kammoe, Romuald BriceMaster studentCHUL+1 418-525-4444, extension 42296Romuald.Babou@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T-1-49
Québec, QC
Canada G1v 4G2 - Babou Kammoe, Romuald BriceDoctoral studentCHUL+1 418-525-4444, extension 42296Romuald.Babou@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T-1-49
Québec, QC
Canada G1v 4G2 - Gauvin, SaraInternsara.gauvin@crchudequebec.ulaval.ca
- Ouattara, Abdoul KarimDoctoral studentCHULabdoul-karim.ouattara.1@ulaval.caabdoul-karim.ouattara@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T-1-49
Québec, QC
Canada G1V 4G2 - Pelletier, JulieEmployeeCHUL+1 418-525-4444, extension 46171+1 418-654-2765julie.pelletier@crchudequebec.ulaval.ca
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2 - Salem, MabroukaPostdoctoral fellowCHUL+1 418-525-4444, extension 46171+1 418-654-2765Mabrouka.Salem@crchudequebec.ulaval.ca
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.
Journal ArticleEur J Med Chem, 208 , pp. 112759, 2020, ISSN: 0223-5234.
Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.
Journal ArticleACS Med Chem Lett, 11 (12), pp. 2397-2405, 2020.
The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling.
Journal ArticleJ Hypertens, 38 (12), pp. 2490-2500, 2020, ISSN: 0263-6352.
Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
Journal ArticleBioorg Chem, 104 , pp. 104305, 2020, ISSN: 0045-2068.
A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins.
Journal ArticleInt J Mol Sci, 21 (19), 2020.
Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer.
Journal ArticleMed Chem, 2020, ISSN: 1573-4064.
Blockade of CD73 delays glioblastoma growth by modulating the immune environment.
Journal ArticleCancer Immunol Immunother, 69 (9), pp. 1801-1812, 2020, ISSN: 0340-7004.
Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines.
Journal ArticleJ Biomol Struct Dyn, pp. 1-14, 2020, ISSN: 0739-1102.
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents.
Journal ArticleBioorg Med Chem Lett, 30 (9), pp. 127067, 2020, ISSN: 0960-894X.
Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes.
Journal ArticlePharm Dev Technol, 25 (4), pp. 408-415, 2020, ISSN: 1083-7450.
Active projects
- A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
Recently finished projects
- Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
- Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, Subvention, Crohn et Colite Canada, from 2019-07-01 to 2020-06-30
- Treating inflammatory Bowel diseases through blocking P2Y6 Receptor, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2018-02-12 to 2019-04-11