The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46319
+1 418-654-2765
jean.sevigny@crchudequebe...

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248 entries « ‹ 1 of 25 › »

Dias AF, Scholl JN, Moritz CEJ, Kagami LP, das Neves GM, Eifler-Lima VL, Cruz-Lopez O, Conejo-Garcia A, Sevigny J, Battastini AMO, Campos JM, Figueiro F

New insights into cytotoxic mechanisms of bozepinib against glioblastoma.

Journal Article

Eur J Pharm Sci, 162 , pp. 105823, 2021, ISSN: 0928-0987.

Abstract | Links:

Manojlovic-Stojanoski M, Lavrnja I, Stevanovic I, Trifunovic S, Ristic N, Nestorovic N, Sevigny J, Nedeljkovic N, Laketa D

Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brain.

Journal Article

Cell Mol Neurobiol, 2021, ISSN: 0272-4340.

Abstract | Links:

Lopes DV, de Fraga Dias A, Silva LFL, Scholl JN, Sevigny J, Battastini AMO, Figueiro F

Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth.

Journal Article

Purinergic Signal, 2021, ISSN: 1573-9538.

Abstract | Links:

Ullah S, El-Gamal MI, El-Gamal R, Pelletier J, Sevigny J, Shehata MK, Anbar HS, Iqbal J

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.

Journal Article

Eur J Med Chem, 217 , pp. 113339, 2021, ISSN: 0223-5234.

Abstract | Links:

Sandhu B, Perez Matos MC, Tran S, Singhal G, Syed I, Feldbrugge L, Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sevigny J, Maratos-Flier E, Robson SC, Jiang ZG

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.

Journal Article

Metabolism, 118 , pp. 154731, 2021, ISSN: 0026-0495.

Abstract | Links:

Babou Kammoe RB, Kauffenstein G, Pelletier J, Robaye B, Sevigny J

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.

Journal Article

Biomolecules, 11 (2), 2021, ISSN: 2218-273X.

Abstract | Links:

Lopez V, Schakel L, Schuh HJM, Schmidt MS, Mirza S, Renn C, Pelletier J, Lee SY, Sevigny J, Alban S, Bendas G, Muller CE

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39.

Journal Article

Mar Drugs, 19 (2), 2021.

Abstract | Links:

Salem M, Lecka J, Pelletier J, Gomes Marconato D, Dumas A, Vallieres L, Brochu G, Robaye B, Jobin C, Sevigny J

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.

Journal Article

Gut, 2021, ISSN: 0017-5749.

Abstract | Links:

Ahmad H, Ullah S, Rahman F, Saeed A, Pelletier J, Sevigny J, Hassan A, Iqbal J

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.

Journal Article

Eur J Med Chem, 208 , pp. 112759, 2020, ISSN: 0223-5234.

Abstract | Links:

Ashraf A, Shafiq Z, Khan Jadoon MS, Tahir MN, Pelletier J, Sevigny J, Yaqub M, Iqbal J

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.

Journal Article

ACS Med Chem Lett, 11 (12), pp. 2397-2405, 2020.

Abstract | Links:

248 entries « ‹ 1 of 25 › »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, Subvention, Crohn et Colite Canada, from 2019-07-01 to 2020-06-30
  • Treating inflammatory Bowel diseases through blocking P2Y6 Receptor, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2018-02-12 to 2019-04-11
Data provided by the Université Laval research projects registery