The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
240 entries « 1 of 24 »

Ahmad H, Ullah S, Rahman F, Saeed A, Pelletier J, Sevigny J, Hassan A, Iqbal J

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.

Journal Article

Eur J Med Chem, 208 , pp. 112759, 2020, ISSN: 0223-5234.

Abstract | Links:

Ashraf A, Shafiq Z, Khan Jadoon MS, Tahir MN, Pelletier J, Sevigny J, Yaqub M, Iqbal J

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.

Journal Article

ACS Med Chem Lett, 11 (12), pp. 2397-2405, 2020.

Abstract | Links:

Lammers MD, Aneli NM, de Oliveira GG, de Oliveira Maciel SFV, Zanini D, Manica A, de Resende E Silva DT, Bagatini MD, Sevigny J, De Sa CA, Manfredi LH, Cardoso AM

The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling.

Journal Article

J Hypertens, 38 (12), pp. 2490-2500, 2020, ISSN: 0263-6352.

Abstract | Links:

Anbar HS, El-Gamal R, Ullah S, Zaraei SO, Al-Rashida M, Zaib S, Pelletier J, Sevigny J, Iqbal J, El-Gamal MI

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.

Journal Article

Bioorg Chem, 104 , pp. 104305, 2020, ISSN: 0045-2068.

Abstract | Links:

Pelletier J, Agonsanou H, Manica F, G Lavoie E, Salem M, Luyindula P, Babou Kammoe RB, Sevigny J

A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins.

Journal Article

Int J Mol Sci, 21 (19), 2020.

Abstract | Links:

Iqbal J, Basharat A, Bano S, Abid SMA, Pelletier J, Sevigny J

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer.

Journal Article

Med Chem, 2020, ISSN: 1573-4064.

Abstract | Links:

Azambuja JH, Schuh RS, Michels LR, Iser IC, Beckenkamp LR, Roliano GG, Lenz GS, Scholl JN, Sevigny J, Wink MR, Stefani MA, Battastini AMO, Figueiro F, Teixeira HF, Braganhol E

Blockade of CD73 delays glioblastoma growth by modulating the immune environment.

Journal Article

Cancer Immunol Immunother, 69 (9), pp. 1801-1812, 2020, ISSN: 0340-7004.

Abstract | Links:

Aziz H, Mahmood A, Zaib S, Saeed A, El-Seedi HR, Pelletier J, Sevigny J, Iqbal J

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines.

Journal Article

J Biomol Struct Dyn, pp. 1-14, 2020, ISSN: 0739-1102.

Abstract | Links:

Varano F, Catarzi D, Vincenzi F, Pasquini S, Pelletier J, Lopes Rangel Fietto J, Espindola Gelsleichter N, Sarlandie M, Guilbaud A, Sevigny J, Varani K, Colotta V

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents.

Journal Article

Bioorg Med Chem Lett, 30 (9), pp. 127067, 2020, ISSN: 0960-894X.

Abstract | Links:

Teixeira FC, Bruxel F, Azambuja JH, Berenguer AM, Stefani MA, Sevigny J, Spanevello RM, Battastini AMO, Teixeira HF, Braganhol E

Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes.

Journal Article

Pharm Dev Technol, 25 (4), pp. 408-415, 2020, ISSN: 1083-7450.

Abstract | Links:

240 entries « 1 of 24 »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, Subvention, Crohn et Colite Canada, from 2019-07-01 to 2020-06-30
  • Treating inflammatory Bowel diseases through blocking P2Y6 Receptor, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2018-02-12 to 2019-04-11
Data provided by the Université Laval research projects registery