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Scientific publications

  • article Aftab H, Dutt SM, Mali SN, Vigiani E, Pelletier J, Sévigny J, Gurav SS, Jawarkar RD, Almalki AS, Akram MS, Batool Z, Schenone S, Iqbal J, Shafiq Z

    Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 4-Propylsulfonylpiperazines-Based Thiosemicarbazones as Ecto-5-Nucleotidase and NTPDase Inhibitors

    Arch Pharm (Weinheim) 358 (9), 2025.

    DOI PUBMED
  • article de Moraes JVB, Polêto MD, de Castro RB, Bressan GC, de S Vasconcellos R, Sévigny J, Fietto JR

    Structural Modeling of NTPDase-Substrate Complexes Preserving Catalytic Experimental Features

    ACS Omega 10 (38), 2025.

    DOI PUBMED
  • article Bi C, Mirza S, Baburi H, Schäkel L, Winzer R, Moschütz S, Keetz K, Lopez V, Pelletier J, Sévigny J, Schulze Zur Wiesch J, Claff T, Tolosa E, Namasivayam V, Sträter N, Müller CE

    Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate

    ACS Pharmacol Transl Sci 8 (5), 2025.

    DOI PUBMED
  • article Manica FM, Campesato LFI, Scholl JN, Braganhol E, Bergamin LS, Edelweiss MIA, Lenz G, Sevigny J, Figueiró F, Battastini AMO

    Assessing Ecto-5′-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells

    Neurochem Res 50 (3), 2025.

    DOI PUBMED
  • article Salarpour F, Sévigny J

    P2Y2 Receptor Signaling in Health and Disease

    Int J Mol Sci 26 (19), 2025.

    DOI PUBMED
  • article Kelestemur T, Robson SC, Németh ZH, Pacher P, Arif M, Aydin MS, Suzek BE, Pelletier J, Lunsford KE, Schwabe RF, Geng Y, Sévigny J, Haskó G

    NTPDase8 Protects Against Liver Ischemia-Reperfusion Injury in Mice

    FASEB J 39 (13), 2025.

    DOI PUBMED
  • article Pinto-Cardoso R, Bessa-Andrês C, Pereira-Costa F, Neiva R, Martins-Ferreira R, Guerra-Leal B, Nóbrega Catelas D, Vilaça A, Oliveira A, Pelletier J, Sévigny J, Noronha-Matos JB, Correia-de-Sá P

    HIF-1α Stabilization Hampers the Chondrogenic Differentiation of Aged Bone Marrow Mesenchymal Stem Cells by Adenosine A2A/A2B Receptors Imbalance

    ACS Pharmacol Transl Sci 8 (7), 2025.

    DOI PUBMED
  • article Silva LFL, Scholl JN, Weber AF, Dias CK, Pizzato PR, Lima VP, Sévigny J, Battastini AMO, Figueiró F

    Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells

    Oncol Res 33 (4), 2025.

    DOI PUBMED
  • article Batool Z, Dutt SM, Al-Rashida M, Gelsleichter NE, Pelletier J, Sévigny J, Islam T, Aftab H, Almutairi TM and Çakır F, Shafiq Z, Iqbal J

    N-hexylsulfonyl indole based thiosemicarbazones as potent and selective ecto-5′-nucleotidase and NTPDase inhibitors

    Bioorg Chem 163 2025.

    DOI PUBMED
  • article da Silva ÁC, Scholl JN, de Fraga Dias A, Weber AF, Morrone FB, Cruz-López O, Conejo-García A, Campos JM, Sévigny J, Figueiró F, Battastini AMO

    Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme

    Purinergic Signal 21 (1), 2025.

    DOI PUBMED
  • article Rodríguez-Martínez A, Torrejón-Escribano B, Eritja N, Dorca-Arévalo J, Gabaldón C, Sévigny J, Matias-Guiu X, Martín-Satué M

    Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors

    Histol Histopathol 40 (2), 2025.

    DOI PUBMED
  • article Babou Kammoe RB, Sévigny J

    Extracellular nucleotides in smooth muscle contraction

    Biochem Pharmacol 220 2024.

    DOI PUBMED