Frédéric Bretzner
Chercheur universitaire
Axe Neurosciences
CHUL
P-09800
Québec, Québec
Canada G1V 4G2
Full professor
Department of Psychiatry and Neuroscience
Faculty of Medicine
Frederic Bretzner is a full professor in the Department of Psychiatry and Neurosciences at the Faculty of Medicine, Université Laval, and a researcher in the Neurosciences program at the CHU de Québec-Université Laval Research Center. He completed his PhD at Université de Montréal (Québec), focusing on the plasticity of the motor cortex after peripheral nerve injury, followed by a postdoctoral fellowship at the University of British Columbia in Vancouver (British Columbia), where he studied the plasticity of the red nucleus after spinal cord injury. He then undertook a second postdoctoral fellowship at Dalhousie University in Halifax (Nova Scotia), investigating the role of brainstem neurons in motor control.
He has been awarded three FRQS scholarships (2012–2024) and the Turnbull-Tator Award for spinal cord injury research (2013 and 2023), which recognizes outstanding contributions to the field of spinal cord and brain injury research. Since 2012, he has led a research team specializing in the neural control of movement and locomotion in both physiological and neuropathological settings at the Centre de recherche du CHU de Québec-Université Laval.
Using transgenic and mutant mice, his research group has developed tools to assess changes in locomotor gaits following genetic mutations, spinal cord injury, and neuromodulation aimed at enhancing motor recovery. By combining kinematics, electrophysiological recordings, and genetic tools accessible in the mouse model, his team has recently characterized the functional contributions of genetically identified neuronal subpopulations in the brainstem to locomotor control and recovery from spinal cord injury. These findings have been published in leading journals such as Journal of Neuroscience, PLoS Biology, Current Biology, Cell Reports Medicine, and Nature Communications.
The results of these studies have the potential to improve functional recovery following neurotraumatic injuries or neurodegenerative diseases affecting motor control and locomotion.
Team
Abderraouf Redjem
Étudiant 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 abderraouf.redjem.1@ulaval.ca abderraouf.redjem@crchudequebec.ulaval.ca
Galadriel Germain
Stagiaire
Kayvan Combadiere
Étudiant 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 kayvan.combadiere.1@ulaval.ca kayvan.combadiere@crchudequebec.ulaval.ca
LÏa Mayet
Étudiante 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 lia.mayet.1@ulaval.ca lia.mayet@crchudequebec.ulaval.ca
Rezk Bouleghcha
Stagiaire
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444 Rezk.bouleghcha.1@ulaval.ca
Baptiste Hardoin
Étudiant 2e cycle
Hors CHU
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 baptiste.hardoin.1@ulaval.ca baptiste.hardoin@crchudequebec.ulaval.ca
Océane Marques
Étudiante 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 oceane.marques.1@ulaval.ca
Kayvan Combadiere
Étudiant 3e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 kayvan.combadiere.1@ulaval.ca kayvan.combadiere@crchudequebec.ulaval.ca
Narges Karimi
Étudiante 3e cycle
CHUL
2705, Boul. LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 narges.karimi@crchudequebec.ulaval.ca
Marc-Antoine Bouchard
Étudiant 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 marc-antoine.bouchard@crchudequebec.ulaval.ca
Armen Philippossian
Stagiaire
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 arphi1@ulaval.ca
Noé Brivot
Employé
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 noe.brivot@crchudequebec.ulaval.ca
LÏa Mayet
Étudiante 3e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 lia.mayet.1@ulaval.ca lia.mayet@crchudequebec.ulaval.ca
Maxime Lemieux
Employé
CHUL
2705, boulevard LaurierP-09824
Québec, Québec
Canada G1V 4G2 +1 418 525-4444, poste 48258 maxime.lemieux.1@ulaval.ca maxime.lemieux@crchudequebec.ulaval.ca
Susana Cristina Soares Lima
Stagiaire postdoctorale
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 susana-cristina.soares-lima@crchudequebec.ulaval.ca
Yasmine Zmantar
Étudiante 2e cycle
CHUL
2705, boulevard LaurierP-09800
Québec, QC
Canada G1V 4G2 +1 418 525-4444, poste 47077 yasmine.zmantar@crchudequebec.ulaval.ca
Publications
View all-
article Law NY, Desrosiers S, Sivanesan S, Tonkov H, Charron F, Bretzner F, Srour M, Barthélemy D
Gait Alterations Due to DCC Gene Variants in Individuals with Congenital Mirror Movements
Mov Disord Clin Pract 2026.
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article Menet R, Bernard M, Lecordier S, Trudel E, Allain AS, Distéfano-Gagné F, Seigneur J, Aldib N, Haili Y, Bretzner F, Gosselin D, ElAli A
Dickkopf-1 release by the bone marrow upon ischemic stroke bridges neurovascular and immune deregulations
Brain Behav Immun 134 2026.
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article Tabourin L, Bretzner F, Galstian T
Lightweight mini-endoscope for two color imaging of neural activities with large field of view
Results in Optics 16 2024.
Projects
- Distinct functional contribution of Sub-Thalamic Locomotor Region nuclei to motor control before and after spinal cord injury, from 2023-10-01 to 2026-09-30
- Genetic dissection of propriospinal interneuronal pathways and their reticulospinal inputs pertaining to locomotor control and recovery after spinal cord injury, from 2023-10-01 to 2028-09-30
- Role of DSCAM in the development and maintenance of motor circuits, from 2024-04-01 to 2029-03-31
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury, from 2025-01-01 to 2026-12-31
- Investigating the Amygdala’s Kiss: How Early-Life Obesity Shapes Pubertal Development, from 2025-03-01 to 2029-03-31
- Deep brain photometry of spatially distinct brain areas using a single optical fiber, from 2022-03-31 to 2025-03-30
- Functional contribution of Mesencephalic Locomotor Region nuclei in chronic Parkinson’s disease, from 2025-01-01 to 2026-06-30