Associate professor
Department of Molecular Biology, Medical Biochemistry, and Pathology
Faculty of Medicine

Prof. Bordeleau joined the CHU de Québec-Université Laval Research Centre in 2018 following his stay at Cornell University, and then at Vanderbilt University. He is a Associate Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine at Université Laval. The laboratory specializes in the field of mechanobiology , i.e. the field of research interested in the impact and contribution of physical forces and mechanical properties of both cells and tissues on biological functions. His main interest lies in cancer, and he holds the Canada Research Chair in Mechanobiology of Tumors and Cellular Mechanoregulation.

Prof. Bordeleau has an interdisciplinary background and has a background in engineering, physics, and cell and molecular biology. This training is transposed into the experimental approaches that are available in the laboratory, ranging from state-of-the-art imaging, the development of a new generation of biomimetic 3D cancer models, the application of quantitative analysis and numerical modeling methods, to the classic tools of cell culture and animal models. The laboratory regularly welcomes students from the physical, biological and biomedical sciences.

The laboratory’s research program is based on 3 distinct themes:

  • Defining the mechanisms allowing cells to adapt to the evolution of matrix rigidity in tumors.
  • Developing quantitative approaches to predict cancer progression based on tumor cell mechanical state and tumor microenvironment mechanical properties.
  • Harnessing advances and innovation from the field of biomedical engineering to develop new biomimetic models of the tumour microenvironment.

The laboratory’s work is at the interface between basic and translational research, and works in close collaboration with clinicians. The laboratory also has an ever-expanding network of international collaborations.