David Gosselin
Chercheur universitaire
Axe Neurosciences
Dernières nouvelles
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Publications
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article Distéfano-Gagné F, Belhamiti N, Saxon W, Bitarafan S, Xavier AM, Fiola S, Rivest S, Gosselin D
Multi-tier signaling and chromatin remodeling coordinate microglia inflammatory states and activities associated with demyelination
Cell Rep 45 (7), 2026.
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article Menet R, Bernard M, Lecordier S, Trudel E, Allain AS, Distéfano-Gagné F, Seigneur J, Aldib N, Haili Y, Bretzner F, Gosselin D, ElAli A
Dickkopf-1 release by the bone marrow upon ischemic stroke bridges neurovascular and immune deregulations
Brain Behav Immun 134 2026.
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article Drake SS, Mohammadnia A, Zaman A, Gianfelice C, Heale K, Groh AMR, Hua EM, Hintermayer MA, Lu YR, Gosselin D, Zandee S, Prat A, Stratton JA, Sinclair DA, Fournier AE
Cellular rejuvenation protects neurons from inflammation-mediated cell death
Cell Rep 44 (2), 2025.
Projets
- Targeting Mef2 transcription factor activity to stimulate pro-repair activity of microglia in demyelinating diseases, du 2026-04-01 au 2029-03-31
- Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, du 2020-03-01 au 2025-03-31
- Enhancing microglial myelin repair mechanisms through stimulation of the Ppar-delta nuclear receptor as a novel therapeutic approach for multiple sclerosis, du 2020-09-01 au 2024-08-31
- Understanding and rejuvenating microglial phagocytosis as mean to inhibit progression of tauopathies in a mouse model of Alzheimer’s Disease, du 2020-10-01 au 2025-09-30
- Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders, du 2021-04-01 au 2026-03-31
- Étude des mécanismes de la régulation épigénétique et transcriptionnelle responsable des fonctions des microglies, du 2022-01-01 au 2024-08-31
- Étude des mécanismes de la régulation épigénétique et transcriptionelle responsables des fonctions des microglies dans le, du 2023-07-01 au 2025-06-30