Le système IRM préclinique 1 Tesla, M2 (Aspect Imaging) permet l’imagerie du petit animal en produisant les mêmes effets de contraste et de signal qu’un appareil à champ magnétique clinique. Le laboratoire possède une vaste expertise dans le domaine des études longitudinales de perfusion sanguine, de suivi de masses tumorales et d’implants pour la médecine régénératrice, ainsi que du développement de biomatériaux à base d’hydrogels impliquant le suivi par IRM.
Imagerie par résonance magnétique (IRM)
Équipement
M2™ Système IRM compact à haute performance (Aspect Imaging), avec champ magnétique de 1 Tesla.
Le système permet de prendre des scans en 2D et en 3D avec une résolution pouvant aller jusqu’à 85 µm. Il est équipé d’un dispositif d’anesthésie à l’isoflurane et d’un système de surveillance permettant un contrôle de la fréquence respiratoire dans le petit animal.
Caractéristiques techniques :
- Antennes disponibles : 60 mm, 35 mm, tête de souris, plaque de 96 puits.
- Séquences disponibles : mesures en pondération T1, T2, diffusion, cartographie T1 et T2, etc.
- Observation anatomique de la structure des tissus (principalement les tissus mous)
- Informations moléculaires et tissulaires
- Génération de fichiers standard DICOM
Exemples de résultats
Source: Leon-Chaviano S, Kiseleva M, Legros P, Collin S, Lescot T, Henoumont C, Gossuin Y, Laurent S, Mayrand D, Fradette J, Bégin-Drolet A, Ruel J, Fortin MA. A Nanoparticle Ink Allowing the High Precision Visualization of Tissue Engineered Scaffolds by MRI; Small, 19 (30), 2023.
Source: Kiseleva M, Lescot T, Selivanova SV, Fortin MA. Gold-Enhanced Brachytherapy by a Nanoparticle-Releasing Hydrogel and 3D-Printed Subcutaneous Radioactive Implant Approach. Adv Healthc Mater, 12 (23), 2023
Source: Xiao, WC; Legros, P; Fortin, MA. Superparamagnetic Iron Oxide Nanoparticles Stabilized with Multidentate Block Copolymers for Optimal Vascular Contrast in T1-Weighted Magnetic Resonance Imaging; Feb 2018; 1 (2), pp.894-907.
Source: Bouchard M, Letourneau M, Sarra-Bournet C, Laprise-Pelletier M, Turgeon S, Chevallier P, Lagueux J, Laroche G, Fortin MA. Rapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry. Langmuir, 31 (27), 2015.
Source: Chan N, Laprise-Pelletier M, Chevallier P, Bianchi A, Fortin MA, Oh JK. Multidentate block-copolymer-stabilized ultrasmall superparamagnetic iron oxide nanoparticles with enhanced colloidal stability for magnetic resonance imaging. Biomacromolecules, 15 (6), 2014.
Source : Labo BIM (modèle murin : J.Fradette, CR-CHUQ-UL)
Source: Chevallier P, Walter A, Garofalo A, Veksler I, Lagueux J, Bégin-Colin S, Felder-Flesch D, Fortin MA. Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging. J Mater Chem B, 2 (13), 2014.
Source: Kiseleva M, Omar MM, Boisselier É, Selivanova SV, Fortin MA. A Three-Dimensional Printable Hydrogel Formulation for the Local Delivery of Therapeutic Nanoparticles to Cervical Cancer. ACS Biomater Sci Eng, 8 (3), 2022.
Source: Faucher L, Tremblay M, Lagueux J, Gossuin Y, Fortin MA. Rapid synthesis of PEGylated ultrasmall gadolinium oxide nanoparticles for cell labeling and tracking with MRI. ACS Appl Mater Interfaces, 4 (9), 2012.
Publications
- Leon-Chaviano S, Kiseleva M, Legros P, Collin S, Lescot T, Henoumont C, Gossuin Y, Laurent S, Mayrand D, Fradette J, Bégin-Drolet A, Ruel J, Fortin MAA Nanoparticle Ink Allowing the High Precision Visualization of Tissue Engineered Scaffolds by MRI; Small, 19 (30), 2023.
https://pubmed.ncbi.nlm.nih.gov/36965146/ - Kiseleva M, Lescot T, Selivanova SV, Fortin MAGold-Enhanced Brachytherapy by a Nanoparticle-Releasing Hydrogel and 3D-Printed Subcutaneous Radioactive Implant Approach. Adv Healthc Mater, 12 (23), 2023
https://pubmed.ncbi.nlm.nih.gov/37094373/ - Laprise-Pelletier M, Lagueux J, Cote MF, LaGrange T, Fortin MALow-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles. Adv Healthc Mater, 6 (4), 2017.
https://pubmed.ncbi.nlm.nih.gov/28116855/ - Proulx M, Aubin K, Lagueux J, Audet P, Auger M, Fortin MA, Fradette JMagnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes. Tissue Eng Part C Methods, 21 (7), 2015.
https://pubmed.ncbi.nlm.nih.gov/25549069/
- Fortin MA, Magnetic Nanoparticles Used as Contrast Agents in MRI: Relaxometric Characterisation. Kumar C (Ed.): Magnetic Characterization Techniques for Nanomaterials, p. 511-555, Berlin, Springer-Verlag, 2017, ISBN: 9783662527795
- Xiao, WC; Legros, P; (…); Fortin, MA; Superparamagnetic Iron Oxide Nanoparticles Stabilized with Multidentate Block Copolymers for Optimal Vascular Contrast in T1-Weighted Magnetic Resonance Imaging; Feb 2018; 1 (2), pp.894-907.
https://pubs.acs.org/doi/abs/10.1021/acsanm.7b00300 - Bouchard M, Letourneau M, Sarra-Bournet C, Laprise-Pelletier M, Turgeon S, Chevallier P, Lagueux J, Laroche G, Fortin MARapid Nucleation of Iron Oxide Nanoclusters in Aqueous Solution by Plasma Electrochemistry. Langmuir, 31 (27), 2015.
https://pubmed.ncbi.nlm.nih.gov/26086241/ - Chan N, Laprise-Pelletier M, Chevallier P, Bianchi A, Fortin MA, Oh JKMultidentate block-copolymer-stabilized ultrasmall superparamagnetic iron oxide nanoparticles with enhanced colloidal stability for magnetic resonance imaging. Biomacromolecules, 15 (6), 2014.
https://pubmed.ncbi.nlm.nih.gov/24785001/
- Xiao, WC; Legros, P; (…); Fortin, MA; Superparamagnetic Iron Oxide Nanoparticles Stabilized with Multidentate Block Copolymers for Optimal Vascular Contrast in T1-Weighted Magnetic Resonance Imaging; Feb 2018; 1 (2), pp.894-907.
https://pubs.acs.org/doi/abs/10.1021/acsanm.7b00300 - Proulx M, Aubin K, Lagueux J, Audet P, Auger M, Fortin MA, Fradette J. Magnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes. Tissue Eng Part C Methods, 21 (7), 2015.
https://pubmed.ncbi.nlm.nih.gov/25549069/ - Chevallier P, Walter A, Garofalo A, Veksler I, Lagueux J, Bégin-Colin S, Felder-Flesch D, Fortin MA Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging. J Mater Chem B, 2 (13), 2014.
https://univoak.eu/islandora/object/islandora%3A60162/datastream/PDF/view
- Leon-Chaviano S, Kiseleva M, Legros P, Collin S, Lescot T, Henoumont C, Gossuin Y, Laurent S, Mayrand D, Fradette J, Bégin-Drolet A, Ruel J, Fortin MAA Nanoparticle Ink Allowing the High Precision Visualization of Tissue Engineered Scaffolds by MRI; Small, 19 (30), 2023.
https://pubmed.ncbi.nlm.nih.gov/36965146/ - Kiseleva M, Omar MM, Boisselier É, Selivanova SV, Fortin MAA Three-Dimensional Printable Hydrogel Formulation for the Local Delivery of Therapeutic Nanoparticles to Cervical Cancer. ACS Biomater Sci Eng, 8 (3), 2022.
https://pubmed.ncbi.nlm.nih.gov/35226460/
- Faucher L, Tremblay M, Lagueux J, Gossuin Y, Fortin MARapid synthesis of PEGylated ultrasmall gadolinium oxide nanoparticles for cell labeling and tracking with MRI. ACS Appl Mater Interfaces, 4 (9), 2012.
https://pubmed.ncbi.nlm.nih.gov/22834680/