{"id":66523,"date":"2024-05-14T14:01:01","date_gmt":"2024-05-14T18:01:01","guid":{"rendered":"https:\/\/www.crchudequebec.ulaval.ca\/platforms-and-services\/genomics-center\/proteomique\/traitement-bio-informatique-et-statistique\/"},"modified":"2024-07-09T12:15:02","modified_gmt":"2024-07-09T16:15:02","slug":"traitement-bio-informatique-et-statistique","status":"publish","type":"page","link":"https:\/\/www.crchudequebec.ulaval.ca\/en\/platforms-and-services\/genomics-center\/proteomique\/traitement-bio-informatique-et-statistique\/","title":{"rendered":"Bioinformatics and statistical analysis"},"content":{"rendered":"<section class=\"bg-white align wp-block-acf-content-with-left-sidebar\">\n    <div class=\"container\">\n    <div class=\"padd padd--bottom\">\n        <div class=\"wrap\">\n            <div class=\"flex md:flex-row flex-col md:gap-x-[8.3%] gap-x-3 md:gap-y-0 gap-y-8\">\n                <div class=\"sidebar md:w-1\/4 w-full flex flex-col gap-y-8\">\n                    \n                    \n                                                                        <div>\n                                                                    <h3 class=\"mb-0 text-16 font-bold\">Director<\/h3>\n                                \n                                                                    <div class=\"mb-1\">\n                                        Arnaud Droit, Ph.D.\n                                    <\/div>\n                                \n                                \n                                \n                                                            <\/div>\n                                                    <div>\n                                                                    <h3 class=\"mb-0 text-16 font-bold\">Coordinator<\/h3>\n                                \n                                                                    <div class=\"mb-1\">\n                                        Florence Roux-Dalvai, M.Sc.\n                                    <\/div>\n                                \n                                \n                                \n                                                            <\/div>\n                                                    <div>\n                                                                    <h3 class=\"mb-0 text-16 font-bold\">Proteomics<\/h3>\n                                \n                                                                    <div class=\"mb-1\">\n                                        2705 boul. Laurier, local R2-2710<br \/>\r\nQu\u00e9bec (Qu\u00e9bec) Canada G1V 4G2\n                                    <\/div>\n                                \n                                                                    <div class=\"mb-1\">\n                                                                                    \n                                            <a class=\"phone\" href=\"tel:+1 418-654-2261\">+1 418-654-2261<\/a>\n                                                                                    \n                                            <a class=\"phone\" href=\"tel:+1 418-654-2159 (fax)\">+1 418-654-2159 (fax)<\/a>\n                                                                            <\/div>\n                                \n                                                                    <ul class=\"emails !mb-3\">\n                                                                                    <li class=\"overflow-hidden\">\n                                                <a class=\"group flex items-center\" href=\"mailto:prot\u00e9omique@crchudequebec.ulaval.ca\" title=\"prot\u00e9omique@crchudequebec.ulaval.ca\">\n                                                    <i class=\"fa-light fa-envelope shrink-0 group-hover:text-blue-500 duration-300\"><\/i>\n                                                    <span class=\"text-16 whitespace-nowrap overflow-hidden text-ellipsis group-hover:text-blue-500 duration-300\">prot\u00e9omique@crchudequebec.ulaval.ca<\/span>\n                                                <\/a>\n                                            <\/li>\n                                                                            <\/ul>\n                                \n                                                            <\/div>\n                                            \n                    \n                    \n                    \n                                    <\/div>\n                <div class=\"main-content md:w-7\/12 w-full\">\n                    \n                    \n                                            <div class=\"content\">\n                            <div class=\"inner\">\n                                <p><span class=\"TextRun SCXW225473480 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW225473480 BCX0\">Different software programs can be used to obtain the identification and quantification of peptides and proteins present in the sample (e.g., Proteome Discoverer for TMT analyses, <\/span><span class=\"NormalTextRun SCXW225473480 BCX0\">MaxQuant<\/span><span class=\"NormalTextRun SCXW225473480 BCX0\"> for DDA analyses, DIA-NN for DIA analyses, Skyline for targeted analyses).<\/span><\/span><span class=\"EOP SCXW225473480 BCX0\" data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h4><b><span data-contrast=\"none\">Identification<\/span><\/b><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h4>\n<p><a href=\"https:\/\/www.crchudequebec.ulaval.ca\/en\/platforms-and-services\/genomics-center\/proteomique\/identification-des-proteines\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Peptide identification<\/span><\/a><span data-contrast=\"none\"> is based on comparing data from mass spectrometers with protein sequences available in public databases (Uniprot.org). For species with incomplete proteomes in the databases, alternative methods can be applied, such as using databases of closely related species or genomic data.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Peptides are then grouped by protein based on the principle of parsimony, taking into account the different isoforms present in the database. Therefore, groups of proteins are considered rather than individual proteins.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Lists of identified peptides and proteins are validated at 1% FDR using the target-decoy method, which estimates the number of false positives in the identification list.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h4><span class=\"TextRun SCXW143801064 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW143801064 BCX0\">Quantification<\/span><\/span><span class=\"EOP SCXW143801064 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h4>\n<p>F<span data-contrast=\"none\">or <\/span><a href=\"https:\/\/www.crchudequebec.ulaval.ca\/en\/platforms-and-services\/genomics-center\/proteomique\/proteomique-quantitative\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">quantification analyses<\/span><\/a><span data-contrast=\"none\">, two methods are possible depending on whether it is a TMT-labeled experiment or an label-free quantification (LFQ) experiment.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">For TMT analyses, the software extracts intensities of reporter ions for each peptide. Each of these ions provides the intensity of the peptide in the different samples.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">For LFQ analyses (and targeted analyses), the software aligns different injections from the same experiment and uses spectral data to reconstruct the elution profile of each peptide in each sample (i.e., in each analysis). Integration of the area under the elution peak allows obtaining a quantification value.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">To maximize quantification data, information is cross-referenced between different injections to search for signals corresponding to the same peptides even if they are of low intensity (match between runs).<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">In all cases, the software performs data normalization specific to proteomic data based on the entire signal observed in each sample. It is also possible to obtain non-normalized data to apply other normalization methods.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Data Representation and Statistics<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">For quantitative analyses, we use R software to obtain graphical representations and statistics from data generated by proteomic software.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">We produce principal component analysis (PCA) and heatmaps to visualize the overall proteomic profile of each sample and assess variability between them.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-65188 aligncenter\" src=\"https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_1.png\" alt=\"\" width=\"637\" height=\"416\" srcset=\"https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_1.png 637w, https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_1-300x196.png 300w\" sizes=\"auto, (max-width: 637px) 100vw, 637px\" \/><\/p>\n<p><span class=\"TextRun SCXW212751874 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">We<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> can <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">also<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">perform<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">comparisons<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">between<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">two<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> conditions\/groups of <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">interest<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">pairwise<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">analysis<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\">) by <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">calculating<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> a ratio and a <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">statistical<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> test (Welch test, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">Limma<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\">) for <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">each<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> of the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">obtained<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">proteins<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\">. Ratios are <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">centered<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> (z-score <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">calculation<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\">) and p-values <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">from<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">statistical<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> test are <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">adjusted<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> for multiple <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">testing<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">using<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">Benjamini-Hochberg<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">method<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> to <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">obtain<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> q-values. <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">Proteins<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">with<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> |z|&gt;1.96 and q &lt; 0.05 are <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">considered<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">significantly<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">regulated<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">between<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> groups. This information <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">is<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">represented<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> in <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212751874 BCX0\">volcano<\/span><span class=\"NormalTextRun SCXW212751874 BCX0\"> plots.<\/span><\/span><span class=\"EOP SCXW212751874 BCX0\" data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-65190 aligncenter\" src=\"https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_2.png\" alt=\"\" width=\"768\" height=\"456\" srcset=\"https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_2.png 768w, https:\/\/www.crchudequebec.ulaval.ca\/wp-content\/uploads\/2024\/06\/Proteomique_Services_Bioinfo_2-300x178.png 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/p>\n<p><span class=\"TextRun SCXW222212956 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">Other<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> tests and <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">graphical<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">representations<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> can <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">also<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">be<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">obtained<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">from<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">proteomic<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> data as <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">needed<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> for the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">project<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> (ANOVA, box plots, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW222212956 BCX0\">correlation<\/span><span class=\"NormalTextRun SCXW222212956 BCX0\"> plots, clustering).<\/span><\/span><span class=\"EOP SCXW222212956 BCX0\" data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h4><span class=\"TextRun SCXW225445337 BCX0\" lang=\"FR-FR\" xml:lang=\"FR-FR\" data-contrast=\"none\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225445337 BCX0\">Other<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW225445337 BCX0\">Bioinformatics<\/span> <span class=\"NormalTextRun SCXW225445337 BCX0\">Analyses<\/span><\/span><span class=\"EOP SCXW225445337 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h4>\n<p><span class=\"NormalTextRun SpellingErrorV2Themed SpellingErrorHighlight SCXW5281656 BCX0\">Upon<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">request<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\">, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">we<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> can <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">also<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">perform<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> more <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">advanced<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">bioinformatics<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> analyses <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">such<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> as <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">functional<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> analyses (Gene <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">Ontology<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\">, KEGG <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">pathways<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\">), interaction network analyses, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">biomarker<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> signature <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">searches<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\">, or multi-<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">omics<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> analyses. <\/span><\/p>\n<p><span class=\"NormalTextRun SCXW5281656 BCX0\">For <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">this<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\">, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">we<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">closely<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">collaborate<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">with<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> the <\/span><a href=\"https:\/\/www.crchudequebec.ulaval.ca\/en\/platforms-and-services\/genomics-center\/bio-informatique\/\" target=\"_blank\" rel=\"noopener\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">bioinformatics<\/span><\/a><span class=\"NormalTextRun SCXW5281656 BCX0\"> platform of the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW5281656 BCX0\">Genomics<\/span><span class=\"NormalTextRun SCXW5281656 BCX0\"> Center<\/span><\/p>\n\n                            <\/div>\n                        <\/div>\n                    \n                    \n                    \n                    \n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>The proteomics platform offers a complete service including bioinformatics processing of results, with statistical calculations and graphical representations for quantification. <\/p>\n","protected":false},"author":10,"featured_media":0,"parent":46835,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-66523","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bioinformatics and statistical analysis - Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.crchudequebec.ulaval.ca\/en\/platforms-and-services\/genomics-center\/proteomique\/traitement-bio-informatique-et-statistique\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" 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