Yves Tremblay is a full professor at Laval University in the Department of Obstetrics, Gynecology & Reproduction, and a senior scientist at the CHU de Québec-Laval University Research Center. He obtained his bachelor’s degree in 1979 and his PhD in physiology and molecular endocrinology in 1984 from Laval University’s School of Medicine. From 1985-1990, he pursued three post- doctoral training programs at the Louis-Pasteur University in Strasbourg, France on steroid receptor molecular biology, at the University of Montreal on molecular biology of the endocrine systems, and at the University of California in San Francisco in the Department of Pediatrics, on molecular biology of human steroidogenic enzymes. He is the co-founder of the eBook strategic initiative that uses the Web-based discussion forum to approach the delicate question of being born too soon. Between 2005 and 2011, he was member of the Institute Advisory Board of the Institute of Gender and Health from the Canadian Institutes of Health Research. Between 2011 and 2015, he was the Director for the Respiratory Health Network from the Fonds de Recherche Québec en Santé. Meanwhile, he was also a member, and then President of the Board of Directors of the Quebec Lung Association. Since August 2015, he has been the President of the International and Interdisciplinary Association on the Pharmaceutical Life Cycle. He has also served over the last 20 years on several provincial, national, and international committees.

Research Interest

For over 25 years, the development of Dr. Tremblay’s research expertise has been directly related to fetal development and gene expression of the steroidogenesis-specific enzymes involved in the metabolism of steroid hormones in gonads, adrenals, and peripheral tissues, including both placenta and fetal lungs. Androgens synthesized by the fetal lungs, estradiol synthesized by the placenta, and regulation of the fetal lungs by glucocorticoids do control key events in fetal development by means of their cell-type specific expression, temporal regulation, and regionalization in their presence and action; in all cases, a disruption in the metabolism and problems associated with the action of androgens and estrogens during pregnancy and a deregulation of glucocorticoid in the fetal lungs is directly related to developmental syndrome and pathologies, namely respiratory distress syndrome and bronchopulmonary dysplasia disease. This research presents specific aspects that hold potential for clinical applications: studying the metabolism and regulation of steroid hormones by the lungs is applicable to many sectors of physiology, including modelization, while their action on fetal development, and, more specifically, lung maturation and development, has clinical potential in human health. More recently, our research on lung development in early life has indicated a potential interest for emphysema, a disease for which we have no curative treatment.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46158
yves.tremblay@crchudequeb...

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Sallon C, Soulet D, Provost PR, Tremblay Y

Automated High-Performance Analysis of Lung Morphometry

Journal Article

Am J Respir Cell Mol Biol, 53 (2), 2015.

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Simard M, Gagne AM, Lambert RD, Tremblay Y

A transdisciplinary approach to the decision-making process in extreme prematurity

Journal Article

BMC Res Notes, 7 , 2014.

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Boucher E, Provost PR, Tremblay Y

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung

Journal Article

BMC Res Notes, 7 , 2014.

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Bouhaddioui W, Provost PR, Tremblay Y

Identification of most stable endogenous control genes for microRNA quantification in the developing mouse lung

Journal Article

PLoS One, 9 (11), 2014.

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Morisset AS, Dube MC, Drolet R, Pelletier M, Labrie F, Luu-The V, Tremblay Y, Robitaille J, Weisnagel SJ, John Weisnagel S, Tchernof A

Androgens in the maternal and fetal circulation: association with insulin resistance

Journal Article

J Matern Fetal Neonatal Med, 26 (5), 2013.

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Tremblay Y, Provost PR

Major enzymes controlling the androgenic pressure in the developing lung

Journal Article

J Steroid Biochem Mol Biol, 137 , 2013.

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Provost PR, Boucher E, Tremblay Y

Glucocorticoid metabolism in the developing lung: adrenal-like synthesis pathway

Journal Article

J Steroid Biochem Mol Biol, 138 , 2013.

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Simard M, Boucher É, Tremblay Y

The influence of Mars and Venus on lung development: implications for biomedical research and beyond

Book Chapter

L'influence du genre et du sexe, un recueil de cas sur la recherche liée au genre, au sexe et à la santé, pp. 8-16, Vancouver, BC, Institute of Gender and Health of the Canadian Institutes of Health Research, 2012, ISBN: 9781100192505.

Simard M, Boucher É, Tremblay Y

L’influence de Mars et Vénus sur le développement pulmonaire : implications en recherche biomédicale et au-delà

Book Chapter

What a difference sex and gender make a gender, sex and health research casebook, pp. 9-18, Vancouver, BC, Instituts de recherche en santé du Canada, 2012, ISBN: 9781100979212.

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Bousquet J, Schunemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, Canonica GW, Casale TB, Cruz AA, Fokkens WJ, Fonseca JA, van Wijk RG, Grouse L, Haahtela T, Khaltaev N, Kuna P, Lockey RF, Lodrup Carlsen KC, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Palkonen S, Papadopoulos NG, Passalacqua G, Pawankar R, Price D, Ryan D, Simons FE, Togias A, Williams D, Yorgancioglu A, Yusuf OM, Aberer W, Adachi M, Agache I, Ait-Khaled N, Akdis CA, Andrianarisoa A, Annesi-Maesano I, Ansotegui IJ, Baiardini I, Bateman ED, Bedbrook A, Beghe B, Beji M, Bel EH, Ben Kheder A, Bennoor KS, Bergmann KC, Berrissoul F, Bieber T, Bindslev Jensen C, Blaiss MS, Boner AL, Bouchard J, Braido F, Brightling CE, Bush A, Caballero F, Calderon MA, Calvo MA, Camargos PA, Caraballo LR, Carlsen KH, Carr W, Cepeda AM, Cesario A, Chavannes NH, Chen YZ, Chiriac AM, Chivato Perez T, Chkhartishvili E, Ciprandi G, Costa DJ, Cox L, Custovic A, Dahl R, Darsow U, De Blay F, Deleanu D, Denburg JA, Devillier P, Didi T, Dokic D, Dolen WK, Douagui H, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, El-Meziane A, Emuzyte R, Fiocchi A, Fletcher M, Fukuda T, Gamkrelidze A, Gereda JE, Gonzalez Diaz S, Gotua M, Guzman MA, Hellings PW, Hellquist-Dahl B, Horak F, Hourihane JO, Howarth P, Humbert M, Ivancevich JC, Jackson C, Just J, Kalayci O, Kaliner MA, Kalyoncu AF, Keil T, Keith PK, Khayat G, Kim YY, Koffi N'goran B, Koppelman GH, Kowalski ML, Kull I, Kvedariene V, Larenas-Linnemann D, Le LT, Lemiere C, Li J, Lieberman P, Lipworth B, Mahboub B, Makela MJ, Martin F, Marshall GD, Martinez FD, Masjedi MR, Maurer M, Mavale-Manuel S, Mazon A, Melen E, Meltzer EO, Mendez NH, Merk H, Mihaltan F, Mohammad Y, Morais-Almeida M, Muraro A, Nafti S, Namazova-Baranova L, Nekam K, Neou A, Niggemann B, Nizankowska-Mogilnicka E, Nyembue TD, Okamoto Y, Okubo K, Orru MP, Ouedraogo S, Ozdemir C, Panzner P, Pali-Scholl I, Park HS, Pigearias B, Pohl W, Popov TA, Postma DS, Potter P, Rabe KF, Ratomaharo J, Reitamo S, Ring J, Roberts R, Rogala B, Romano A, Roman Rodriguez M, Rosado-Pinto J, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Schmid-Grendelmeier P, Sheikh A, Sisul JC, Sole D, Sooronbaev T, Spicak V, Spranger O, Stein RT, Stoloff SW, Sunyer J, Szczeklik A, Todo-Bom A, Toskala E

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs

Journal Article

J Allergy Clin Immunol, 130 (5), 2012.

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Active projects

  • Constipation and Malnutrition in the Elderly in Long-Term Care Facilities, from 2020-08-01 to 2023-01-31

Recently finished projects

  • A Pre-Clinical Research for Treatment of Prematurity and BronchoPulmonary Dysplasia through Intracrinology, from 2018-10-01 to 2021-09-30
  • Steroid hormone synthesis/inactivation and action in terminal lung development., from 2016-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery