Dr. Vincent Pernet has been Assistant Professor in the Department of Ophthalmology at Laval University since 2014. His research focuses on the mechanisms of plasticity and neuronal degeneration in diseases such as glaucoma and diabetic retinopathy, as well as occurring during normal and pathological aging of the visual system.
Enabling the plasticity of visual neurons
With his team, he is interested in molecules likely to alter the functioning of retinal cells, such as the Nogo-A neuronal plasticity inhibitory protein, the proteins involved in Alzheimer’s disease (amyloid and Tau) and the CNTF-Stat3 pathway that governs neuronal growth. Dr. Pernet has demonstrated the important role of the Nogo-A protein in inhibiting the regeneration of the injured optic nerve, and in the plasticity of the visual system, intact or injured. Neutralization of Nogo-A strongly increases neuronal plasticity and visual recovery in ocular disease models. Recently, his team discovered that neutralizing Nogo-A with a blocking antibody also improves vascular repair and retinal function in a proliferative retinopathy model. These results suggest that Nogo-A may be a therapeutic target to restore normal retinal vasculature, and protect the eyesight of patients suffering from diabetic retinopathy or retinopathy of prematurity. Tests are underway to determine the effects of Nogo-A in diabetic retinopathy and glaucoma.
Reducing the effects of normal and pathological aging of the retina
The aging of the visual system is characterized by a decline in retinal function, which can be followed using electroretinographic measurements. The molecular mechanisms responsible for the loss of activity in the eye’s neurons are not known. Dr. Pernet’s lab is trying to identify the factors that influence the observed reorganization of neuronal connections in the retinas of old animals. Ultimately, the results of this work could be used to stimulate functional reconnection of circuits in the aging retina.
Correction: Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune EncephalomyelitisJournal Article
J Immunol, 2023.
Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNSJournal Article
Cell Death Discov, 9 (1), 2023.
B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseasesJournal Article
J Neuroinflammation, 19 (1), 2022.
Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studiesJournal Article
Neurobiol Dis, 161 , 2021.
The Lack of Amyloidogenic Activity Is Persistent in Old WT and APPswe/PS1ΔE9 Mouse RetinaeJournal Article
Int J Mol Sci, 22 (21), 2021.
Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune EncephalomyelitisJournal Article
J Immunol, 206 (9), 2021.
Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injuryJournal Article
Cell Death Dis, 11 (2), 2020.
Tau Gene Deletion does not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual SystemJournal Article
Int J Mol Sci, 21 (11), 2020.
Tau modulates visual plasticity in adult and old miceJournal Article
Neurobiol Aging, 95 , 2020.
Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery SystemJournal Article
Molecules, 24 (16), 2019.
- Mechanisms of neuronal and vascular impairments in ischemic retinopathies, from 2019-04-01 to 2024-03-31