Following her training in Paris, France, Dr. Moulin was recruited in 1998 to better understand the complex process of healing. Since 1998, she has been a professor at the Laval University School of Medicine, Department of Surgery, but also a researcher at the LOEX Center at Laval University, and at the Research Center of the CHU de Quebec. Her work focuses on the normal and pathological mechanisms of skin healing. To perform this, she uses different cell culture models reconstituted by tissue engineering to reproduce in vitro fibrotic skin diseases (hypertrophic scars, scleroderma). Concurrently, she also uses the tissue engineering method to reconstruct cutaneous substitutes to treat skin deficient patients, for example, after burns.

Myofibroblasts in normal or pathological scars
These cells appear during wound healing and play an important role in the contraction of the edges of the wound. Dr. Moulin’s team has shown that these cells also play a central role in the production of extracellular matrix, as well as in angiogenesis. They also have a role in the formation of disabling scars such as hypertrophic scars. Dr. Moulin’s team analyzes the different functions of myofibroblasts in normal or pathological scarring; investigates existing interactions between endothelial cells, keratinocytes, fibroblasts and myofibroblasts, and analyzes the role of extracellular matrix secreted by cells in various cellular functions such as apoptosis, angiogenesis or cell differentiation.

Systemic scleroderma
This pathology is a fibrotic disease that stiffens all organs, including the skin, and is eventually fatal. Dr. Moulin uses a tissue-engineering method to understand this pathology, but especially to determine new treatments to reduce fibrosis.

Clinical application of tissue engineering
Tissue engineering skin production is carried out from patients’ cells and then grafted onto them to allow wound closure in patients who are unable to heal after extensive burns or other pathologies. The properties of skin reconstructed by our method are being evaluated in a clinical trial accepted by Health Canada to cover burn victims.

1401, 18e Rue
R-225
Québec, Québec
Canada G1J 1Z4
+1 418-990-8251+1 418-990-8255, extension 61715
veronique.moulin@crchudeq... veronique.moulin@fmed.ula...

Latest news

72 entries « ‹ 1 of 8 › »

Espinoza-Moya ME, Laberge M, Bélanger L, Chang SL, Poder TG, Moulin VJ, Germain L, Beaudoin Cloutier C, Guertin JR

Adaptation of a standardized self-reported cost questionnaire specific for the severe burn injury population (BI-CoPaQ)

Journal Article

Burns, 2024.

Abstract | Links:

Arif S, Richer M, Larochelle S, Moulin VJ

Microvesicles derived from dermal myofibroblasts modify the integrity of the blood and lymphatic barriers using distinct endocytosis pathways

Journal Article

J Extracell Biol, 3 (5), 2024.

Abstract | Links:

Arif S, Larochelle S, Trudel B, Gounou C, Bordeleau F, Brisson AR, Moulin VJ

The diffusion of normal skin wound myofibroblast-derived microvesicles differs according to matrix composition

Journal Article

J Extracell Biol, 3 (1), 2024.

Abstract | Links:

Arif S, Larochelle S, Trudel B, Gounou C, Bordeleau F, Brisson AR, Moulin VJ

The diffusion of normal skin wound myofibroblast-derived microvesicles differs according to matrix composition

Journal Article

J Extracell Biol, 3 (1), 2024.

Abstract | Links:

Savard É, Magne B, Simard-Bisson C, Martel C, Larouche D, Gauvin R, Moulin VJ, Germain L

Design of an innovative method for measuring the contractile behaviour of engineered tissues

Journal Article

Tissue Eng Part C Methods, 2024.

Abstract | Links:

Dagher J, Arcand C, Auger FA, Germain L, Moulin VJ

The Self-Assembled Skin Substitute History: Successes, Challenges, and Current Treatment Indications

Journal Article

J Burn Care Res, 44 (Suppl_1), 2023.

Abstract | Links:

Naasani LIS, Sévigny J, Moulin VJ, Wink MR

UTP increases wound healing in the self assembled skin substitute (SASS)

Journal Article

J Cell Commun Signal, 17 (3), 2023.

Abstract | Links:

Arif S, Moulin VJ

Extracellular vesicles on the move: Traversing the complex matrix of tissues

Journal Article

Eur J Cell Biol, 102 (4), 2023.

Abstract | Links:

Attiogbe E, Larochelle S, Chaib Y, Mainzer C, Mauroux A, Bordes S, Closs B, Gilbert C, Moulin VJ

An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach

Journal Article

Acta Biomater, 168 , 2023.

Abstract | Links:

Desjardins P, Berthiaume R, Couture C, Le-Bel G, Roy V, Gros-Louis F, Moulin VJ, Proulx S, Chemtob S, Germain L, Guérin SL

Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial Cells

Journal Article

Int J Mol Sci, 23 (20), 2022.

Abstract | Links:

72 entries « ‹ 1 of 8 › »
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Active projects

  • Action des microvésicules dans les tissus solides, from 2019-04-01 to 2025-03-31
  • Allogeneic dermis to accelerate the production of a tissue-engineered skin substitute to treat Canadian burn patients, from 2023-04-01 to 2025-01-31
  • Centre du génie tissulaire (CHU de Québec - Université Laval), from 2019-04-01 to 2025-03-31
  • Combining tissue-engineered skin with ex vivo gene therapy correction to develop a treatment for epidermolysis bullosa, from 2022-04-01 to 2025-01-31
  • Real World Clinical and Economic Burden of Severe Burn Injuries, from 2023-10-01 to 2026-09-30
  • The implication of PlGF in cutaneous fibrosis, from 2022-10-01 to 2027-09-30
  • Tissue engineering to treat Canadian burn patients: the Self-Assembled Skin Substitutes (SASS), from 2022-04-01 to 2026-01-31

Recently finished projects

  • Bioengineering and Long-term Storage of Complex Tissue and Organ Constructs, from 2020-03-31 to 2023-03-30
  • Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles, from 2023-03-31 to 2024-03-31
  • La réponse immunitaire aux peaux reconstruites avec des cellules allogéniques., from 2022-04-01 to 2023-03-31
  • Mise au point par génie tissulaire d'un modèle de cicatrisation cutanée contenant des cellules immunitaires, from 2019-01-27 to 2024-02-29
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients, from 2020-01-01 to 2023-01-31
  • Setting up the conditions for the biobanking of tissues and cells from hypertrophic scars, from 2022-12-01 to 2024-02-28
  • The implication of PlGF in cutaneous fibrosis, from 2022-03-01 to 2023-02-28
Data provided by the Université Laval research projects registery