In addition to being a senior investigator at the CHU de Quebec–Université Laval Research Center and professor in the Faculty of Pharmacy at Laval University, Dr. Di Paolo is also an associate professor at the University of Saskatchewan, Saskatoon, Canada. She received the Janssen-Ortho pharmaceutical research award from the Association of Faculties of Pharmacy of Canada (2002); the Heinz Lehmann prize from the Canadian College of Neuopsychopharmacology, 2003; distinctions: Femmes réussite region Chaudière Appalache, Journal Économique de Québec, 2004, Femme de mérite, YWCA of Québec, Science and technology category, 2006, Empreintes d’elles, YWCA, honoring 400 women, 400th anniversary of Québec City, 2008 and the Diamond prize for excellence in Fundamental Research, Centre Hospitalier Universitaire de Québec, Québec City, 2015.

Dr. Di Paolo has published over 295 peer-reviewed articles and 470 summaries. Her research interest is on Parkinson’s disease and L-Dopa-induced dyskinesias in the post-mortem human brains of Parkinson’s disease patients, non-human primates, and rodent models of Parkinson. This research was and is currently funded by the CIHR, NSERC, Parkinson Society Canada, CQDM, NIH and contracts from Prexton Therapeutics, Novartis, and Merck Serono. 

In recent years, her research has focused on the glutamatergic neurotransmission and the implication of ionotropic and metabotropic glutamate receptors. Various specific antagonists, positive and negative allosteric modulators of glutamate receptors were investigated to inhibit or prevent the development of L-Dopa-induced dyskinesias. Drugs of various pharmacological activities are also investigated in her laboratory including, serotoninergic drugs, omega-3, plasmalogens and dehydroepiandrosterone (DHEA). She recently investigated the effect of a subthalamic lesion on L-Dopa-induced dyskinesias in parkinsonian monkeys, and is now working on the effect of deep stimulation in this area of the brain.

A major research endeavour in her laboratory is also to investigate neuroprotection in a mouse model of Parkinson’s Disease. Repurposing drugs used to treat various endocrine conditions were found to be neuroprotective such as estrogen, progesterone, the selective estrogen receptor modulator raloxifene, and the 5α-reductase inhibitor, dutasteride. Novel non-genomic mechanisms of action were investigated in this neuroprotection, including the implication of the membrane estrogen receptor (GPER1) and the effect of cholesterol on membrane microviscosity.

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Di Paolo T

Molecular connectivity in quantitative structure--activity relationship study of anesthetic and toxic activity of aliphatic hydrocarbons, ethers, and ketones

Journal Article

J Pharm Sci, 67 (4), 1978.

Abstract | Links:

Di Paolo T

Structure--activity relationships of anesthetic ethers using molecular connectivity

Journal Article

J Pharm Sci, 67 (4), 1978.

Abstract | Links:

Beaulieu M, Di Paolo T, Raymond V, Labrie F

Antagonism between estrogens and dopamine at the anterior pituitary level on prolactin secretion

Book Chapter

Usdin E, Kopin IJ, Barchas J (Ed.): Catecholamines: Basic and Clinical Frontiers, pp. 1263-1265, Pergamon, 1978, ISBN: 9781483283630.

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Di Paolo T, Hall LH, Kier LB

Progress toward the development of a receptor model for hallucinogenic amphetamines

Book Chapter

Stillman RC, Willette RE (Ed.): The Psychopharmacology of hallucinogens, pp. 61-72, New York, Pergamon Press, 1978, ISBN: 0080219381.

Di Paolo T, Kier LB

Molecular connectivity and structure-activity relationship of general anesthetics

Journal Article

Mol Pharmacol, 13 (1), 1977.

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Kier LB, Di Paolo T, Hall LH

Structure-activity studies on odor molecules using molecular connectivity

Journal Article

J Theor Biol, 67 (3), 1977.

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Di Paolo T, Sandorfy C

Fluorocarbon anaesthetics break hydrogen bonds

Journal Article

Nature, 252 (5483), 1974.

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Di Paolo T, Sandorfy C

Hydrogen bond breaking potency to fluorocarbon anesthetics

Journal Article

J Med Chem, 17 (8), 1974.

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Di Paolo T, Sandorfy C

On the hydrogen bond breaking ability of fluorocarbons containing higher halogens

Journal Article

Can J Chem, 52 , 1974.

Di Paolo T, Sandorfy C

On the biological importance of the hydrogen bond breaking potency of fluorocarbons

Journal Article

Chem Phys Lett, 26 , 1974.

322 entries « 32 of 33 »
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Active projects

  • Brain magnetic stimulation to reduce levodopa-induced dyskinesias in Parkinson’s disease, from 2024-04-01 to 2026-03-31
  • Mechanisms of action of sex-specific endocrine treatments in complementary models of Parkinson's disease, from 2024-04-01 to 2029-03-31
  • Pregnenolone for the treatment of dyskinesia in Parkinson’s disease, from 2022-04-01 to 2024-09-01

Recently finished projects

  • Mechanisms of action of sex-specific endocrine treatments in animal models of Parkinson's disease, from 2023-03-01 to 2024-02-29
  • Relationship between COVID-19 and Parkinson’s disease in a mouse model, from 2022-10-01 to 2024-03-31
  • Sex-specific investigations of Parkinson's disease mouse models: application for gonadal drugs repurposing, from 2018-10-01 to 2023-03-31
Data provided by the Université Laval research projects registery