Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.
Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).
Understanding early atherosclerosis in rheumatic autoimmune diseases:
Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.
A new target to treat leukemia:
Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.
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Crystal-induced neutrophil activation. II. Evidence for the activation of a phosphatidylcholine-specific phospholipase D
Journal ArticleArthritis Rheum, 36 (1), 1993.
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Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human neutrophils in vitro: role of calcium, G-proteins and tyrosine kinases
Journal ArticleCell Signal, 4 (5), 1992.
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Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: evidence for an involvement of phospholipase D-derived phosphatidic acid
Journal ArticleCell Signal, 3 (6), 1991.
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Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography
Journal ArticleMethods Enzymol, 187 , 1990.
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Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol
Journal ArticleJ Exp Med, 172 (3), 1990.
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Altered formation of leukotriene B4 in vitro by synovial fluid neutrophils in rheumatoid arthritis
Journal ArticleJ Rheumatol, 16 (3), 1989.
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils
Journal ArticleAgents Actions, 27 (3-4), 1989.
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Studies on the effects of disease-modifying antirheumatic drugs on lipoxygenase product synthesis in human neutrophils in vitro
Journal ArticleInt J Immunopharmacol, 10 (6), 1988.
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[Effect of SIN-1 on the synthesis of leukotrienes in human polymorphonuclear cells]
Journal ArticlePathol Biol (Paris), 35 (2 Pt 2), 1987.
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Active projects
- Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases, from 2023-01-01 to 2025-12-31
Recently finished projects
- Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., from 2015-07-01 to 2023-03-31