Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.

Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).

Understanding early atherosclerosis in rheumatic autoimmune diseases:

Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.

A new target to treat leukemia:

Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.

CHUL
2705, boulevard Laurier
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Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46136
sylvain.bourgoin@crchudeq...

Latest news

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Leblanc PO, Bourgoin SG, Poubelle PE, Tessier PA, Pelletier M

Metabolic regulation of neutrophil functions in homeostasis and diseases

Journal Article

J Leukoc Biol, 116 (3), 2024.

Abstract | Links:

Chouinard FC, Davis L, Gilbert C, Bourgoin SG

Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis

Journal Article

Cells, 12 (1), 2022.

Abstract | Links:

Zhao Y, Aoudjit F, Bourgoin SG

Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model

Journal Article

Int J Mol Sci, 23 (15), 2022.

Abstract | Links:

Hasse S, Julien AS, Duchez AC, Zhao C, Boilard E, Fortin PR, Bourgoin SG

Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus

Journal Article

Lupus Sci Med, 9 (1), 2022.

Abstract | Links:

Gamara J, Davis L, Leong AZ, Pagé N, Rollet-Labelle E, Zhao C, Hongu T, Funakoshi Y, Kanaho Y, Aoudji F, Pelletier M, Bourgoin SG

Corrigendum to "Arf6 regulates energy metabolism in neutrophils" [Free Radic Biol Med. 172 (2021) 550-561]

Journal Article

Free Radic Biol Med, 179 , 2022.

| Links:

Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E

Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules

Journal Article

Blood, 138 (25), 2021.

Abstract | Links:

Zhao Y, Hasse S, Bourgoin SG

Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise

Journal Article

Prog Lipid Res, 83 , 2021.

Abstract | Links:

Gamara J, Davis L, Leong AZ, Pagé N, Rollet-Labelle E, Zhao C, Hongu T, Funakoshi Y, Kanaho Y, Aoudji F, Pelletier M, Bourgoin SG

Arf6 regulates energy metabolism in neutrophils

Journal Article

Free Radic Biol Med, 172 , 2021.

Abstract | Links:

Zhao Y, Hasse S, Vaillancourt M, Zhao C, Davis L, Boilard E, Fortin P, Di Battista J, Poubelle PE, Bourgoin SG

Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis

Journal Article

Int J Mol Sci, 22 (23), 2021.

Abstract | Links:

Hasse S, Duchez AC, Fortin P, Boilard E, Bourgoin SG

Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes

Journal Article

Biochem Pharmacol, 192 , 2021.

Abstract | Links:

110 entries « ‹ 1 of 11 › »
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Active projects

  • Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases, from 2024-04-01 to 2029-03-31
  • Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases, from 2023-01-01 to 2025-12-31

Recently finished projects

  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., from 2015-07-01 to 2023-03-31
Data provided by the Université Laval research projects registery