Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Bilodeau S, Vallette-Kasic S, Gauthier Y, Figarella-Branger D, Brue T, Berthelet F, Lacroix A, Batista D, Stratakis C, Hanson J, Meij B, Drouin J

Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease

Journal Article

Genes Dev, 20 (20), 2006.

Abstract | Links:

Martens C, Bilodeau S, Maira M, Gauthier Y, Drouin J

Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor

Journal Article

Mol Endocrinol, 19 (4), 2005.

Abstract | Links:

Batsche E, Moschopoulos P, Desroches J, Bilodeau S, Drouin J

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

Journal Article

J Biol Chem, 280 (16), 2005.

Abstract | Links:

Batsche E, Desroches J, Bilodeau S, Gauthier Y, Drouin J

Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness

Journal Article

J Biol Chem, 280 (20), 2005.

Abstract | Links:

Maira M, Couture C, Le Martelot G, Pulichino AM, Bilodeau S, Drouin J

The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action

Journal Article

J Biol Chem, 278 (47), 2003.

Abstract | Links:

Bilodeau S, Fortier MA, Sirard MA

Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro

Journal Article

J Reprod Fertil, 97 (1), 1993.

Abstract | Links:

Sirard MA, Coenen C, Bilodeau S

Effect of fresh or cultured follicular fractions on meiotic resumption in bovine oocytes

Journal Article

Theriogenology, 37 (1), 1992.

Abstract | Links:

Sirard MA, Bilodeau S

Effects of granulosa cell co-culture on in-vitro meiotic resumption of bovine oocytes

Journal Article

Reproduction, 89 (2), 1990.

Abstract | Links:

Sirard MA, Bilodeau S

Granulosa cells inhibit the resumption of meiosis in bovine oocytes in vitro

Journal Article

Biol Reprod, 43 (5), 1990.

Abstract | Links:

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Active projects

  • Chaire de recherche du Canada en génomique transcriptionnelle, from 2017-09-01 to 2022-08-31
  • Defining the global transcriptional response to perturbations, from 2021-04-01 to 2026-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response, from 2021-09-01 to 2023-08-31
  • Toward defining the transcriptional ecosystem, from 2019-04-01 to 2024-03-31
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2023-01-14

Recently finished projects

  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), from 2020-03-01 to 2021-02-28
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, from 2017-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery