Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Latest news

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Boudaoud I, Fournier É, Baguette A, Vallée M, Lamaze FC, Droit A, Bilodeau S

Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome

Journal Article

Genetics, 207 (1), 2017.

Abstract | Links:

Fournier M, Bourriquen G, Lamaze FC, Cote MC, Fournier E, Joly-Beauparlant C, Caron V, Gobeil S, Droit A, Bilodeau S

FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells

Journal Article

Sci Rep, 6 , 2016.

Abstract | Links:

Joly Beauparlant C, Lamaze FC, Deschenes A, Samb R, Lemacon A, Belleau P, Bilodeau S, Droit A

Metagene Profiles Analyses Reveal Regulatory Element's Factor-Specific Recruitment Patterns

Journal Article

PLoS Comput Biol, 12 (8), 2016.

Abstract | Links:

Mannini L, C Lamaze F, Cucco F, Amato C, Quarantotti V, Rizzo IM, Krantz ID, Bilodeau S, Musio A

Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome

Journal Article

Sci Rep, 5 , 2015.

Abstract | Links:

Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

Journal Article

Cell Rep, 6 (2), 2014.

Abstract | Links:

Dowen JM, Bilodeau S, Orlando DA, Hubner MR, Abraham BJ, Spector DL, Young RA

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements

Journal Article

Stem Cell Reports, 1 (5), 2013.

Abstract | Links:

Bilodeau S, Cote J

A chromatin switch for chromosome condensation

Journal Article

Dev Cell, 23 (6), 2012.

Abstract | Links:

Welstead GG, Creyghton MP, Bilodeau S, Cheng AW, Markoulaki S, Young RA, Jaenisch R

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

Journal Article

Proc Natl Acad Sci U S A, 109 (32), 2012.

Abstract | Links:

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Journal Article

Nature, 482 (7384), 2012.

Abstract | Links:

Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferre F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

Journal Article

Nature, 471 (7339), 2011.

Abstract | Links:

39 entries « ‹ 2 of 4 › »
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Active projects

  • Chaire de recherche du Canada en génomique transcriptionnelle, from 2017-09-01 to 2022-08-31
  • Defining the global transcriptional response to perturbations, from 2021-04-01 to 2026-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response, from 2021-09-01 to 2023-08-31
  • Toward defining the transcriptional ecosystem, from 2019-04-01 to 2024-03-31
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, from 2020-09-01 to 2022-08-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2023-01-14

Recently finished projects

  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), from 2020-03-01 to 2021-02-28
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, from 2017-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery