Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Latest news

43 entries « ‹ 2 of 5 › »

Silveira MA, Tav C, Bérube-Simard FA, Cuppens T, Leclercq M, Fournier É, Côté MC, Droit A, Bilodeau S

Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

Journal Article

Life Sci Alliance, 4 (5), 2021.

Abstract | Links:

Al Dow M, Silveira MAD, Poliquin A, Tribouillard L, Fournier É, Trébaol E, Secco B, Villot R, Tremblay F, Bilodeau S, Laplante M

Control of adipogenic commitment by a STAT3-VSTM2A axis

Journal Article

Am J Physiol Endocrinol Metab, 320 (2), 2021.

Abstract | Links:

Silveira MAD, Bilodeau S

Defining the Transcriptional Ecosystem

Journal Article

Mol Cell, 72 (6), 2018.

Abstract | Links:

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA

Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Journal Article

Nature, 562 (7728), 2018.

Abstract | Links:

Boudaoud I, Fournier É, Baguette A, Vallée M, Lamaze FC, Droit A, Bilodeau S

Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome

Journal Article

Genetics, 207 (1), 2017.

Abstract | Links:

Fournier M, Bourriquen G, Lamaze FC, Cote MC, Fournier E, Joly-Beauparlant C, Caron V, Gobeil S, Droit A, Bilodeau S

FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells

Journal Article

Sci Rep, 6 , 2016.

Abstract | Links:

Joly Beauparlant C, Lamaze FC, Deschenes A, Samb R, Lemacon A, Belleau P, Bilodeau S, Droit A

Metagene Profiles Analyses Reveal Regulatory Element's Factor-Specific Recruitment Patterns

Journal Article

PLoS Comput Biol, 12 (8), 2016.

Abstract | Links:

Mannini L, C Lamaze F, Cucco F, Amato C, Quarantotti V, Rizzo IM, Krantz ID, Bilodeau S, Musio A

Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome

Journal Article

Sci Rep, 5 , 2015.

Abstract | Links:

Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state

Journal Article

Cell Rep, 6 (2), 2014.

Abstract | Links:

Dowen JM, Bilodeau S, Orlando DA, Hubner MR, Abraham BJ, Spector DL, Young RA

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements

Journal Article

Stem Cell Reports, 1 (5), 2013.

Abstract | Links:

43 entries « ‹ 2 of 5 › »
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Active projects

  • Defining the global transcriptional response to perturbations, from 2021-04-01 to 2026-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes, from 2020-04-01 to 2025-03-31
  • Toward defining the transcriptional ecosystem, from 2019-04-01 to 2025-03-31
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2025-03-31

Recently finished projects

  • Canadian Epigenetics, Environment and Health Research Consortium Network Phase II, from 2019-07-01 to 2023-06-30
  • Targeting the master transcription factor HSF1 in endocrine-resistant breast cancer to restore antiestrogen response, from 2021-09-01 to 2023-08-31
Data provided by the Université Laval research projects registery