Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
H2-04
Québec, Québec
Canada G1S 4L8
+1 418-682-7735
stephanie.proulx@crchudeq... Stephanie.Proulx@fmed.ula...

Latest news

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Proulx S, Guillemette M, Carrier P, Auger FA, Germain L, Giasson CJ, Gaudreault M, Guérin SL

Tissue engineering of the human cornea

Book Chapter

Chirila T, Harkin D (Ed.): Biomaterials and regenerative medicine in ophthalmology, pp. 150-192, Cambridge (UK), Woodhead Publishing (an imprint of Elsevier), 2010, ISBN: 184569743X.

Proulx S, d'Arc Uwamaliya J, Carrier P, Deschambeault A, Audet C, Giasson CJ, Guerin SL, Auger FA, Germain L

Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types

Journal Article

Mol Vis, 16 , 2010.

Abstract | Links:

Paquet C, Larouche D, Bisson F, Proulx S, Simard-Bisson C, Gaudreault M, Robitaille H, Carrier P, Martel I, Duranceau L, Auger FA, Fradette J, Guerin SL, Germain L

Tissue engineering of skin and cornea: Development of new models for in vitro studies

Journal Article

Ann N Y Acad Sci, 1197 , 2010.

Abstract | Links:

Proulx S, Audet C, Uwamaliya Jd, Deschambeault A, Carrier P, Giasson CJ, Brunette I, Germain L

Tissue engineering of feline corneal endothelium using a devitalized human cornea as carrier

Journal Article

Tissue Eng Part A, 15 (7), 2009.

Abstract | Links:

Larouche D, Lavoie A, Proulx S, Paquet C, Carrier P, Beauparlant A, Auger FA, Germain L

[Regenerative medicine: stem cells, cellular and matricial interactions in the reconstruction of skin and cornea by tissue engineering]

Journal Article

Pathol Biol (Paris), 57 (4), 2009.

Abstract | Links:

Proulx S, Bensaoula T, Nada O, Audet C, d'Arc Uwamaliya J, Devaux A, Allaire G, Germain L, Brunette I

Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model

Journal Article

Invest Ophthalmol Vis Sci, 50 (6), 2009.

Abstract | Links:

Proulx S, Bourget JM, Gagnon N, Martel S, Deschambeault A, Carrier P, Giasson CJ, Auger FA, Brunette I, Germain L

Optimization of culture conditions for porcine corneal endothelial cells

Journal Article

Mol Vis, 13 , 2007.

Abstract | Links:

Proulx S, Landreville S, Guérin SL, Salesse C

Integrin alpha5 expression by the ARPE-19 cell line: comparison with primary RPE cultures and effect of growth medium on the alpha5 gene promoter strength

Journal Article

Exp Eye Res, 79 (2), 2004.

Abstract | Links:

Proulx S, Guérin SL, Salesse C

Effect of quiescence on integrin alpha5beta1 expression in human retinal pigment epithelium

Journal Article

Mol Vis, 9 , 2003.

Abstract | Links:

39 entries « ‹ 4 of 4 › »
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Active projects

  • Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles, from 2023-04-01 to 2024-03-31
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, from 2019-10-01 to 2024-09-30
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, from 2018-04-01 to 2024-03-31
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, from 2019-04-01 to 2024-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, from 2020-04-01 to 2023-08-30
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, from 2022-07-01 to 2025-06-30

Recently finished projects

  • DMLA-Transitions , from 2022-01-31 to 2023-01-30
  • Improving Corneal Endothelial Cell Adhesion, from 2017-07-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, from 2018-04-01 to 2023-03-31
  • New Functional Polymers for Next Generation Contact Lenses - a Phase I Project, from 2019-07-01 to 2022-06-30
  • Projet pilote : génie tissulaire de l'endothélium cornéen sur un hydrogel mimiquant une membrane de Descemet, from 2021-02-15 to 2022-03-31
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, from 2019-07-01 to 2021-06-30
Data provided by the Université Laval research projects registery