Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
Québec, Québec
Canada G1S 4L8
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Proulx S, Bensaoula T, Nada O, Audet C, d'Arc Uwamaliya J, Devaux A, Allaire G, Germain L, Brunette I

Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model.

Journal Article

Invest Ophthalmol Vis Sci, 50 (6), 2009.

Abstract | Links:

Proulx S, Bourget JM, Gagnon N, Martel S, Deschambeault A, Carrier P, Giasson CJ, Auger FA, Brunette I, Germain L

Optimization of culture conditions for porcine corneal endothelial cells.

Journal Article

Mol Vis, 13 , 2007.

Abstract | Links:

Proulx S, Landreville S, Guérin SL, Salesse C

Integrin alpha5 expression by the ARPE-19 cell line: comparison with primary RPE cultures and effect of growth medium on the alpha5 gene promoter strength.

Journal Article

Exp Eye Res, 79 (2), 2004.

Abstract | Links:

Proulx S, Guérin SL, Salesse C

Effect of quiescence on integrin alpha5beta1 expression in human retinal pigment epithelium.

Journal Article

Mol Vis, 9 , 2003.

Abstract | Links:

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Active projects

  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, from 2019-10-01 to 2024-09-30
  • Improving Corneal Endothelial Cell Adhesion, from 2017-07-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, from 2018-04-01 to 2023-03-31
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, from 2018-04-01 to 2023-03-31
  • New Functional Polymers for Next Generation Contact Lenses - a Phase I Project, from 2019-07-01 to 2022-06-30
  • Projet pilote : génie tissulaire de l'endothélium cornéen sur un hydrogel mimiquant une membrane de Descemet, from 2021-02-15 to 2022-03-31
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, from 2019-04-01 to 2023-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, from 2020-04-01 to 2022-08-30

Recently finished projects

  • Banque de tissus oculaires pour la recherche en vision., from 2015-10-14 to 2021-03-31
  • Biomarqueurs de la Dystrophie endothéliale cornéenne de Fuchs, from 2020-06-08 to 2020-10-03
  • Implication des kinines dans la DMLA neovasculaire, from 2017-04-01 to 2020-05-31
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, from 2019-07-01 to 2021-06-30
Data provided by the Université Laval research projects registery