Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
H2-04
Québec, Québec
Canada G1S 4L8
+1 418-682-7735
stephanie.proulx@crchudeq... Stephanie.Proulx@fmed.ula...

Latest news

42 entries « ‹ 3 of 5 › »

Bourget JM, Proulx S

Characterization of a corneal endothelium engineered on a self-assembled stromal substitute

Journal Article

Exp Eye Res, 145 , 2016.

Abstract | Links:

Gendron SP, Theriault M, Proulx S, Brunette I, Rochette PJ

Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells

Journal Article

Invest Ophthalmol Vis Sci, 57 (14), 2016.

Abstract | Links:

Bostan C, Theriault M, Forget KJ, Doyon C, Cameron JD, Proulx S, Brunette I

In Vivo Functionality of a Corneal Endothelium Transplanted by Cell-Injection Therapy in a Feline Model

Journal Article

Invest Ophthalmol Vis Sci, 57 (4), 2016.

Abstract | Links:

Bourget JM, Morcos M, Zaniolo K, Guérin SL, Proulx S

Influence of Cell Confluency on the Expression of the α4 Integrin Subunit of Retinal Pigment Epithelial Cells

Journal Article

Adv Biol Chem, 5 , 2015.

| Links:

Jay L, Bourget JM, Goyer B, Singh K, Brunette I, Ozaki T, Proulx S

Characterization of tissue-engineered posterior corneas using second- and third-harmonic generation microscopy

Journal Article

PLoS One, 10 (4), 2015.

Abstract | Links:

Roy O, Leclerc VB, Bourget JM, Theriault M, Proulx S

Understanding the process of corneal endothelial morphological change in vitro

Journal Article

Invest Ophthalmol Vis Sci, 56 (2), 2015.

Abstract | Links:

Boulze Pankert M, Goyer B, Zaguia F, Bareille M, Perron MC, Liu X, Cameron JD, Proulx S, Brunette I

Biocompatibility and functionality of a tissue-engineered living corneal stroma transplanted in the feline eye

Journal Article

Invest Ophthalmol Vis Sci, 55 (10), 2014.

Abstract | Links:

Zaniolo K, Bostan C, Rochette Drouin O, Deschambeault A, Perron MC, Brunette I, Proulx S

Culture of human corneal endothelial cells isolated from corneas with Fuchs endothelial corneal dystrophy

Journal Article

Exp Eye Res, 94 (1), 2012.

Abstract | Links:

Proulx S, Brunette I

Methods being developed for preparation, delivery and transplantation of a tissue-engineered corneal endothelium

Journal Article

Exp Eye Res, 95 (1), 2012.

Abstract | Links:

Haydari MN, Perron MC, Laprise S, Roy O, Cameron JD, Proulx S, Brunette I

A short-term in vivo experimental model for Fuchs endothelial corneal dystrophy

Journal Article

Invest Ophthalmol Vis Sci, 53 (10), 2012.

Abstract | Links:

42 entries « ‹ 3 of 5 › »
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Active projects

  • A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies, from 2024-04-01 to 2029-03-31
  • Banque de tissus oculaires pour la recherche en vision, from 2015-10-14 to 2025-02-01
  • Influence de l’environnent biomécanique et biochimique sur la formation des jonctions intercellulaires et sur la fonctionnalité du tissu., from 2024-04-01 to 2029-03-31
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, from 2019-04-01 to 2025-03-31
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, from 2022-07-01 to 2025-06-30

Recently finished projects

  • Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles, from 2023-03-31 to 2024-03-31
  • DMLA-Transitions , from 2022-01-31 to 2023-01-30
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, from 2019-10-01 to 2024-09-30
  • Improving Corneal Endothelial Cell Adhesion, from 2017-07-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, from 2018-04-01 to 2023-03-31
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, from 2018-04-01 to 2024-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, from 2020-04-01 to 2024-08-30
Data provided by the Université Laval research projects registery