Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
H2-04
Québec, Québec
Canada G1S 4L8
41 entries « 1 of 5 »

Tchatchouang A, Brunette I, Rochette PJ, Proulx S

Expression and Impact of Fibronectin, Tenascin-C, Osteopontin, and Type XIV Collagen in Fuchs Endothelial Corneal Dystrophy

Journal Article

Invest Ophthalmol Vis Sci, 65 (4), 2024.

Abstract | Links:

Sasseville S, Karami S, Tchatchouang A, Charpentier P, Anney P, Gobert D, Proulx S

Biomaterials used for tissue engineering of barrier-forming cell monolayers in the eye

Journal Article

Front Bioeng Biotechnol, 11 , 2023.

Abstract | Links:

Méthot S, Proulx S, Brunette I, Rochette PJ

The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression

Journal Article

Invest Ophthalmol Vis Sci, 64 (5), 2023.

Abstract | Links:

Méthot S, Proulx S, Brunette I, Rochette PJ

Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization

Journal Article

Sci Rep, 13 (1), 2023.

Abstract | Links:

Santerre K, Cortez Ghio S, Proulx S

TGF-β-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells

Journal Article

Invest Ophthalmol Vis Sci, 63 (11), 2022.

Abstract | Links:

Desjardins P, Berthiaume R, Couture C, Le-Bel G, Roy V, Gros-Louis F, Moulin VJ, Proulx S, Chemtob S, Germain L, Guérin SL

Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial Cells

Journal Article

Int J Mol Sci, 23 (20), 2022.

Abstract | Links:

Santerre K, Proulx S

Isolation efficiency of collagenase and EDTA for the culture of corneal endothelial cells

Journal Article

Mol Vis, 28 , 2022.

Abstract | Links:

Xu I, Thériault M, Brunette I, Rochette PJ, Proulx S

Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy

Journal Article

Exp Eye Res, 205 , 2021.

Abstract | Links:

Anney P, Thériault M, Proulx S

Hydrodynamic forces influence the gene transcription of mechanosensitive intercellular junction associated genes in corneal endothelial cells

Journal Article

Exp Eye Res, 206 , 2021.

Abstract | Links:

Santerre K, Xu I, Theriault M, Proulx S

In Vitro Expansion of Corneal Endothelial Cells for Transplantation

Journal Article

Methods Mol Biol, 2145 , 2020.

Abstract | Links:

41 entries « 1 of 5 »
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Active projects

  • A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies, from 2024-04-01 to 2029-03-31
  • Banque de tissus oculaires pour la recherche en vision., from 2015-10-14 to 2025-02-01
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, from 2019-10-01 to 2024-09-30
  • Influence de l’environnent biomécanique et biochimique sur la formation des jonctions intercellulaires et sur la fonctionnalité du tissu., from 2024-04-01 to 2029-03-31
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, from 2019-04-01 to 2025-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, from 2020-04-01 to 2024-08-30
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, from 2022-07-01 to 2025-06-30

Recently finished projects

  • Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles, from 2023-03-31 to 2024-03-31
  • DMLA-Transitions , from 2022-01-31 to 2023-01-30
  • Improving Corneal Endothelial Cell Adhesion, from 2017-07-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, from 2018-04-01 to 2023-03-31
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, from 2018-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery