Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.

Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2

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Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR

An elaborate pathway required for Ras-mediated epigenetic silencing

Journal Article

Nature, 449 (7165), 2007.

Abstract | Links:

Gobeil S, Letartre L, Raymond V

Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion

Journal Article

Exp Eye Res, 82 (6), 2006.

Abstract | Links:

Fan BJ, Leung DY, Wang DY, Gobeil S, Raymond V, Tam PO, Lam DS, Pang CP

Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma

Journal Article

Arch Ophthalmol, 124 (1), 2006.

Abstract | Links:

Gobeil S, Rodrigue MA, Moisan S, Nguyen TD, Polansky JR, Morissette J, Raymond V

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants

Journal Article

Invest Ophthalmol Vis Sci, 45 (10), 2004.

Abstract | Links:

Boucher C, Gobeil S, Samejima K, Earnshaw WC, Poirier GG

Identification and analysis of caspase substrates: proteolytic cleavage of poly(ADP-ribose)polymerase and DNA fragmentation factor 45

Journal Article

Methods Cell Biol, 66 , 2001.

| Links:

Gobeil S, Boucher CC, Nadeau D, Poirier GG

Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

Journal Article

Cell Death Differ, 8 (6), 2001.

Abstract | Links:

Affar EB, Gobeil S, Germain M, Winstall E, Shah R, Bourassa S, St-Cyr J, Boucher C, Poirier GG

Determination of Poly(ADP-Ribose) polymerase activation and cleavage during cell death

Book Chapter

Szabo C (Ed.): Cell death. The role of PARP, pp. 305-321, Boca Raton, FL, CRC Press, 2000, ISBN: 9780429123818.

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Recently finished projects

  • Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, from 2018-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery