Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.

Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.

CHUL
2705, boulevard Laurier
R-4772
Québec, Québec
Canada G1V 4G2

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37 entries « 2 of 4 »

Sheta R, Wang ZQ, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Macdonald E, Vanderhyden B, Bachvarov D

Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner

Journal Article

Oncotarget, 8 (47), 2017.

Abstract | Links:

Secco B, Camire E, Briere MA, Caron A, Billong A, Gelinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad E, Marsolais D, Bosse Y, Birsoy K, Laplante M

Amplification of Adipogenic Commitment by VSTM2A

Journal Article

Cell Rep, 18 (1), 2017.

Abstract | Links:

Fortin S, Charest-Morin X, Turcotte V, Lauvaux C, Lacroix J, Cote MF, Gobeil S, C-Gaudreault R

Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells

Journal Article

J Med Chem, 60 (12), 2017.

Abstract | Links:

Faddaoui A, Sheta R, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Ghani K, Bachvarov D

Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells

Journal Article

Cell Cycle, 16 (7), 2017.

Abstract | Links:

Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Macdonald E, Vanderhyden B, Bachvarov D

The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells

Journal Article

Oncotarget, 7 (12), 2016.

Abstract | Links:

Fournier M, Bourriquen G, Lamaze FC, Cote MC, Fournier E, Joly-Beauparlant C, Caron V, Gobeil S, Droit A, Bilodeau S

FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells

Journal Article

Sci Rep, 6 , 2016.

Abstract | Links:

Mokas S, Lariviere R, Lamalice L, Gobeil S, Cornfield DN, Agharazii M, Richard DE

Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification

Journal Article

Kidney Int, 90 (3), 2016.

Abstract | Links:

Cote MF, Turcotte A, Doillon C, Gobeil S

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation

Journal Article

J Vis Exp, (114), 2016.

Abstract | Links:

Pedanou VE, Gobeil S, Tabaries S, Simone TM, Zhu LJ, Siegel PM, Green MR

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

Journal Article

Elife, 5 , 2016.

Abstract | Links:

Renault AL, Lesueur F, Coulombe Y, Gobeil S, Soucy P, Hamdi Y, Desjardins S, Le Calvez-Kelm F, Vallee M, Voegele C, , Hopper JL, Andrulis IL, Southey MC, John EM, Masson JY, Tavtigian SV, Simard J

ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry

Journal Article

PLoS One, 11 (6), 2016.

Abstract | Links:

37 entries « 2 of 4 »
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Recently finished projects

  • Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, from 2018-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery