Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.
Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.
2705, boulevard Laurier
Canada G1V 4G2
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Identification of new ETV6 modulators through a high-throughput functional screeningJournal Article
iScience, 25 (3), 2022.
Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancerJournal Article
Bioorg Med Chem, 45 , 2021.
ZNF768 links oncogenic RAS to cellular senescenceJournal Article
Nat Commun, 12 (1), 2021.
Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic AcidJournal Article
Nutrients, 13 (8), 2021.
Deletion of S100a8 and S100a9 Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced PsoriasisJournal Article
J Immunol, 206 (3), 2021.
Synthesis and evaluation of substituted phenyl cycloalkylureas and bioisosteres as IL-6 expression inhibitorsJournal Article
Med Chem Res, 20 (8), 2020.
Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugsJournal Article
J Pharm Pharmacol, 72 (2), 2020.
The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer ProgressionJournal Article
Int J Mol Sci, 20 (9), 2019.
Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133Journal Article
Pharmacol Res, 128 , 2018.
Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lungJournal Article
Int J Dev Biol, 62 (11-12), 2018.
Recently finished projects
- Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, from 2018-04-01 to 2021-03-31