Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.

Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.

CHUL
2705, boulevard Laurier
R-4772
Québec, Québec
Canada G1V 4G2

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37 entries « 1 of 4 »

Neveu B, Richer C, Cassart P, Caron M, Jimenez-Cortes C, St-Onge P, Fuchs C, Garnier N, Gobeil S, Sinnett D

Identification of new ETV6 modulators through a high-throughput functional screening

Journal Article

iScience, 25 (3), 2022.

Abstract | Links:

Vézina-Dawod S, Perreault M, Guay LD, Gerber N, Gobeil S, Biron E

Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer

Journal Article

Bioorg Med Chem, 45 , 2021.

Abstract | Links:

Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, Caron D, Bérubé JS, Bérubé JC, Coulombe Y, Orain M, Gélinas Y, Gobeil S, Bossé Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M

ZNF768 links oncogenic RAS to cellular senescence

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Thérien A, Cieślak A, Verreault M, Perreault M, Trottier J, Gobeil S, Vohl MC, Barbier O

Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid

Journal Article

Nutrients, 13 (8), 2021.

Abstract | Links:

Defrene J, Berrazouane S, Esparza N, Page N, Cote MF, Gobeil S, Aoudjit F, Tessier PA

Deletion of and Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis

Journal Article

J Immunol, 206 (3), 2021.

Abstract | Links:

Tremblay S, Boutin J, Perreault M, Côté MF, Gobeil S, C.-Gaudreault R

Synthesis and evaluation of substituted phenyl cycloalkylureas and bioisosteres as IL-6 expression inhibitors

Journal Article

Med Chem Res, 20 (8), 2020.

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Zarifi Khosroshahi M, Corin Chavez Alvarez A, Gagne-Boulet M, C-Gaudreault R, Gobeil S, Fortin S

Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs

Journal Article

J Pharm Pharmacol, 72 (2), 2020.

Abstract | Links:

Sheta R, Bachvarova M, Macdonald E, Gobeil S, Vanderhyden B, Bachvarov D

The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression

Journal Article

Int J Mol Sci, 20 (9), 2019.

Abstract | Links:

Perreault M, Maltais R, Kenmogne LC, Letourneau D, LeHoux JG, Gobeil S, Poirier D

Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133

Journal Article

Pharmacol Res, 128 , 2018.

Abstract | Links:

Clemenceau A, Boucherat O, Landry-Truchon K, Lamontagne M, Biardel S, Joubert P, Gobeil S, Secco B, Laplante M, Morissette M, Obeidat M, Timens W, Jeannotte L, Bossé Y

Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung

Journal Article

Int J Dev Biol, 62 (11-12), 2018.

Abstract | Links:

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Recently finished projects

  • Substituted phenyl alkylureas as new potent antipsoriatic drugs: Mechanism of action and structure-activity relationships., from 2015-07-01 to 2020-06-30
  • Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, from 2018-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery