Regular scientist at the CHU de Québec-Université Laval Research Center and full professor in the Department of Molecular Medicine at the Laval University Medical School. He is a renowned Canadian scientist who has contributed to the advancement and acceptance of major new scientific concepts. This work has demonstrated that the CNS is a highly immunologically active organ, with complex immune responses, mostly based on innate immune processes. Such responses implicate a continuum of heterogeneous cell types, both inside the CNS, in the periphery, and at their interface, the blood brain barrier (BBB). The goal here is to manipulate such a system to prevent and cure brain diseases. Canadian Research Chair in Neuroimmunology, Twice named Quebec laureate, Radio Canada and Le Soleil (2007 et 2013). Over 21 000 citations and H factor 81.

The immune system at the rescue of brain diseases

The inflammatory response in neurodegenerative diseases has often been linked to progressive neuronal damage. However, mounting evidence now suggests that CNS-resident microglia and circulating monocytes that differentiate into macrophages upon infiltrating the cerebral tissue may exert more beneficial effects on neurons than previously thought. The innate immune system in the brain exhibits a dual nature, as best exemplified by multiple sclerosis (MS) and Alzheimer’s disease (AD), which are often treated as being brain diseases with similar immune etiologies. In reality, they are rather “Yin and Yang” in that regard.

Thus, the role of the inflammatory response seems highly divergent between MS and AD. On the one hand, the marked and sustained activation of proinflammatory monocytic cells promotes demyelination and axonal loss in MS, but on the other hand, it is the anti-inflammatory (or inactivated) phenotype of these cells that allows CNS amyloid accumulation, neuronal dysfunction and memory decline in AD. This research program is focused on thoroughly unraveling the mechanistic details of the role of the innate immune system in the CNS, and how it can be tackled to exert neuroprotective actions.

Vision: A multidisciplinary approach, integrating innovative discoveries and technologies, to validate the concept of the neuroprotective properties of the innate immune system, to improve brain disease diagnosis and treatment.

Goals: Our main goals are to provide new biomarkers for diagnosis and to obtain proofs-of-concept that will lead to new treatments of brain diseases based on the neuroprotective functions of innate immunity.

Objectives: 1) To decipher the molecular and cellular mechanisms involved in the intimate control of different compartments of the brain innate immune system. 2) To identify new biomarkers from the analysis of subsets of circulating monocytes in preclinical models of MS and AD. 3) To use and develop complementary models and methods to understand how myeloid cells can be harnessed in exerting neuroprotective actions. 4) To validate new biomarkers and concepts of the beneficial role of the innate immune system in humans.

CHUL
2705, boulevard Laurier
T4-50
Québec, Québec
Canada G1V 4G2
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Lee J, Villarreal OD, Wang YC, Ragoussis J, Rivest S, Gosselin D, Richard S

PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system

Journal Article

Life Sci Alliance, 5 (10), 2022.

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Ghareghani M, Zibara K, Rieter RJ, Rivest S

Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone

Journal Article

Expert Rev Mol Med, 2022.

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Ghareghani M, Farhadi Z, Rivest S, Zibara K

PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis

Journal Article

Front Immunol, 13 , 2022.

Abstract | Links:

Micule I, Lace B, Wright NT, Chrestian N, Strautmanis J, Diriks M, Stavusis J, Kidere D, Kleina E, Zdanovica A, Laflamme N, Rioux N, Setty ST, Pajusalu S, Droit A, Lek M, Rivest S, Inashkina I

Case Report: Two Families With HPDL Related Neurodegeneration

Journal Article

Front Genet, 13 , 2022.

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Pons V, Rivest S

Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease

Journal Article

Pharmacol Rev, 74 (1), 2022.

Abstract | Links:

Gervais É, Iloun P, Martianova E, Gonçalves Bessa AC, Rivest S, Topolnik L

Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease

Journal Article

J Comp Neurol, 530 (9), 2022.

Abstract | Links:

Belhocine S, Machado Xavier A, Distéfano-Gagné F, Fiola S, Rivest S, Gosselin D

Context-dependent transcriptional regulation of microglial proliferation

Journal Article

Glia, 70 (3), 2022.

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Al-Onaizi MA, Thériault P, Lecordier S, Prefontaine P, Rivest S, ElAli A

Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression

Journal Article

Brain Behav Immun, 99 , 2022.

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Lecordier S, Pons V, Rivest S, ElAli A

Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner

Journal Article

Front Immunol, 12 , 2021.

Abstract | Links:

Laflamme N, Lace B, Thonta Setty S, Rioux N, Labrie Y, Droit A, Chrestian N, Rivest S

A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy

Journal Article

Front Neurol, 12 , 2021.

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Active projects

  • Chaire de recherche du Canada en neuroimmunologie, from 2016-07-01 to 2023-06-30
  • Chercheur d'un jour, from 2021-01-01 to 2022-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases, from 2022-04-01 to 2025-03-31
  • Therapeutic properties of innate immune cells and system for brain diseases., from 2015-07-01 to 2022-06-30

Recently finished projects

  • Neurophotonics Initiative, phase II, from 2015-10-01 to 2021-03-30
  • Programme de soutien aux organismes de recherche et d'innovation (MESI_CATALIS Volet 2 - Recherche clinique) , from 2020-04-23 to 2022-03-31
  • Role of NOD-like receptors in lung immune response against respiratory virus infection, from 2012-10-01 to 2021-02-23
  • Soutenir les établissements dans l'augmentation de leur capacité en recherche - agir sur la phase de démarrage des projets , from 2019-04-01 to 2021-03-31
  • Soutenir les établissements dans l'augmentation de leur capacité en recherche - agir sur la phase de démarrage des projets, Phase 2, from 2020-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery