Dr. Hébert was born in Montréal in 1974. He studied biotechnology, and obtained his Ph.D. in Cellular and Molecular Biology at Laval University in 2003. He then completed a postdoctoral fellowship in human genetics at the Katholieke Universiteit Leuven in Belgium. In 2009, he was recruited as Assistant Professor at Laval University. Dr. Hébert is currently an Associate Professor in the Department of Psychiatry and Neuroscience at Laval University. He is also a researcher (group leader) in the Neuroscience Unit of the Research Center of the CHU de Québec – Laval University.

Dr. Hébert’s work focuses on the biological and molecular mechanisms that cause neuronal death and dementia. Specifically, his research team studies the role of micro-RNAs in the development, diagnosis, and treatment of neurodegenerative diseases such as Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease. Micro-RNAs are small molecules in the body that are similar to DNA and regulate the level of proteins. Dr. Hébert’s pioneering research has shown that many micro-RNAs are deregulated in patients with Alzheimer’s disease, and other types of dementia. Curiously, a number of these molecules can reproduce the pathological and clinical symptoms of dementia in biological models on their own, such as cultured neurons and mice. Dr. Hébert also uses the postmortem human brain as an indispensable tool for his research.

Recently, his work on a potential treatment for Alzheimer’s disease was presented by Le Soleil, the FM93 radio station, and The Alzheimer’s Society of Canada’s Website.

Dr. Hébert has received various awards, including the Alzheimer’s Society of Saskatchewan’s Young Investigator Grant (2010) and the FRQS Junior Research Scholar Career Award (2011, 2014). He has been a spokesperson for the Alzheimer’s Society of Canada (2011). In addition to his commitment to teaching, he regularly participates in various evaluation committees and conferences. Finally, he helps organize events and promote basic Canadian research on Alzheimer’s disease, and related dementias.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 49233
+1 418-654-2753
Sebastien.Hebert@crchudeq...

Latest news

75 entries « ‹ 7 of 8 › »

Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

Journal Article

Proc Natl Acad Sci U S A, 105 (17), 2008.

Abstract | Links:

Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hebert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription

Journal Article

Exp Cell Res, 314 (13), 2008.

Abstract | Links:

O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hebert SS, De Strooper B, Haass C, Bennett DA, Vassar R

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

Journal Article

Neuron, 60 (6), 2008.

Abstract | Links:

Hebert SS, De Strooper B

Molecular biology. miRNAs in neurodegeneration

Journal Article

Science, 317 (5842), 2007.

| Links:

Hebert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, Muller U, De Strooper B

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

Journal Article

EMBO Rep, 7 (7), 2006.

Abstract | Links:

Kasri NN, Kocks SL, Verbert L, Hebert SS, Callewaert G, Parys JB, Missiaen L, De Smedt H

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells

Journal Article

Cell Calcium, 40 (1), 2006.

Abstract | Links:

Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, Tousseyn T, Hebert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

Journal Article

Proc Natl Acad Sci U S A, 102 (5), 2005.

Abstract | Links:

Reinhard C, Hebert SS, De Strooper B

The amyloid-beta precursor protein: integrating structure with biological function

Journal Article

EMBO J, 24 (23), 2005.

Abstract | Links:

Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

Journal Article

EMBO J, 24 (16), 2005.

Abstract | Links:

Hebert SS, Serneels L, Dejaegere T, Horre K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

Journal Article

Neurobiol Dis, 17 (2), 2004.

Abstract | Links:

75 entries « ‹ 7 of 8 › »
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Active projects

  • Importance of non-canonical microRNAs in the mammalian brain, from 2020-04-01 to 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2020-03-01 to 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Étude in vivo des microARNs dans les maladies neurodégénératives, from 2019-07-01 to 2022-06-30
  • microRNA-132: from underlying mechanism of neurodegeneration to therapeutic application in Huntington’s disease, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery