Dr. Hébert was born in Montréal in 1974. He studied biotechnology, and obtained his Ph.D. in Cellular and Molecular Biology at Laval University in 2003. He then completed a postdoctoral fellowship in human genetics at the Katholieke Universiteit Leuven in Belgium. In 2009, he was recruited as Assistant Professor at Laval University. Dr. Hébert is currently an Associate Professor in the Department of Psychiatry and Neuroscience at Laval University. He is also a researcher (group leader) in the Neuroscience Unit of the Research Center of the CHU de Québec – Laval University.

Dr. Hébert’s work focuses on the biological and molecular mechanisms that cause neuronal death and dementia. Specifically, his research team studies the role of micro-RNAs in the development, diagnosis, and treatment of neurodegenerative diseases such as Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease. Micro-RNAs are small molecules in the body that are similar to DNA and regulate the level of proteins. Dr. Hébert’s pioneering research has shown that many micro-RNAs are deregulated in patients with Alzheimer’s disease, and other types of dementia. Curiously, a number of these molecules can reproduce the pathological and clinical symptoms of dementia in biological models on their own, such as cultured neurons and mice. Dr. Hébert also uses the postmortem human brain as an indispensable tool for his research.

Recently, his work on a potential treatment for Alzheimer’s disease was presented by Le Soleil, the FM93 radio station, and The Alzheimer’s Society of Canada’s Website.

Dr. Hébert has received various awards, including the Alzheimer’s Society of Saskatchewan’s Young Investigator Grant (2010) and the FRQS Junior Research Scholar Career Award (2011, 2014). He has been a spokesperson for the Alzheimer’s Society of Canada (2011). In addition to his commitment to teaching, he regularly participates in various evaluation committees and conferences. Finally, he helps organize events and promote basic Canadian research on Alzheimer’s disease, and related dementias.

CHUL
2705, boulevard Laurier
P-09800
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 49233
+1 418-654-2753
Sebastien.Hebert@crchudeq...

Latest news

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Tournissac M, Bourassa P, Martinez-Cano RD, Vu TM, Hebert SS, Planel E, Calon F

Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation

Journal Article

Mol Metab, 22 , 2019.

Abstract | Links:

St-Amour I, Bosoi CR, Pare I, Ignatius Arokia Doss PM, Rangachari M, Hebert SS, Bazin R, Calon F

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease

Journal Article

J Neuroinflammation, 16 (1), 2019.

Abstract | Links:

Boscher E, Husson T, Quenez O, Laquerrière A, Marguet F, Cassinari K, Wallon D, Martinaud O, Charbonnier C, Nicolas G, Deleuze JF, Boland A, Lathrop M, Frébourg T, , Campion D, Hébert SS, Rovelet-Lecrux A

Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer's Disease

Journal Article

J Alzheimers Dis, 68 (3), 2019.

Abstract | Links:

Foveau B, Correia AS, Hébert SS, Rainone S, Potvin O, Kergoat MJ, Belleville S, Duchesne S, LeBlanc AC,

Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease

Journal Article

J Alzheimers Dis, 67 (3), 2019.

Abstract | Links:

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Journal Article

Cell Rep, 24 (6), 2018.

Abstract | Links:

Hui CW, St-Pierre A, El Hajj H, Remy Y, Hebert SS, Luheshi GN, Srivastava LK, Tremblay ME

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

Journal Article

Front Mol Neurosci, 11 , 2018.

Abstract | Links:

Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hebert SS, Lu Y, Zhu LQ

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease

Journal Article

Biol Psychiatry, 83 (5), 2018.

Abstract | Links:

St-Amour I, Turgeon A, Goupil C, Planel E, Hebert SS

Co-occurrence of mixed proteinopathies in late-stage Huntington's disease

Journal Article

Acta Neuropathol, 135 (2), 2018.

Abstract | Links:

Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hebert SS, Chen JG, Lu Y, Zhu LQ

Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease

Journal Article

Mol Ther, 25 (3), 2017.

Abstract | Links:

Hernandez-Rapp J, Rainone S, Hebert SS

MicroRNAs underlying memory deficits in neurodegenerative disorders

Journal Article

Prog Neuropsychopharmacol Biol Psychiatry, 73 , 2017.

Abstract | Links:

75 entries « ‹ 2 of 8 › »
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Active projects

  • Importance of non-canonical microRNAs in the mammalian brain, from 2020-04-01 to 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2020-03-01 to 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Étude in vivo des microARNs dans les maladies neurodégénératives, from 2019-07-01 to 2022-06-30
  • microRNA-132: from underlying mechanism of neurodegeneration to therapeutic application in Huntington’s disease, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery