Dr. Hébert was born in Montréal in 1974. He studied biotechnology, and obtained his Ph.D. in Cellular and Molecular Biology at Laval University in 2003. He then completed a postdoctoral fellowship in human genetics at the Katholieke Universiteit Leuven in Belgium. In 2009, he was recruited as Assistant Professor at Laval University. Dr. Hébert is currently an Associate Professor in the Department of Psychiatry and Neuroscience at Laval University. He is also a researcher (group leader) in the Neuroscience Unit of the Research Center of the CHU de Québec – Laval University.

Dr. Hébert’s work focuses on the biological and molecular mechanisms that cause neuronal death and dementia. Specifically, his research team studies the role of micro-RNAs in the development, diagnosis, and treatment of neurodegenerative diseases such as Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease. Micro-RNAs are small molecules in the body that are similar to DNA and regulate the level of proteins. Dr. Hébert’s pioneering research has shown that many micro-RNAs are deregulated in patients with Alzheimer’s disease, and other types of dementia. Curiously, a number of these molecules can reproduce the pathological and clinical symptoms of dementia in biological models on their own, such as cultured neurons and mice. Dr. Hébert also uses the postmortem human brain as an indispensable tool for his research.

Recently, his work on a potential treatment for Alzheimer’s disease was presented by Le Soleil, the FM93 radio station, and The Alzheimer’s Society of Canada’s Website.

Dr. Hébert has received various awards, including the Alzheimer’s Society of Saskatchewan’s Young Investigator Grant (2010) and the FRQS Junior Research Scholar Career Award (2011, 2014). He has been a spokesperson for the Alzheimer’s Society of Canada (2011). In addition to his commitment to teaching, he regularly participates in various evaluation committees and conferences. Finally, he helps organize events and promote basic Canadian research on Alzheimer’s disease, and related dementias.

CHUL
2705, boulevard Laurier
R-3701
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 49233
Sebastien.Hebert@crchudeq...

Latest news

83 entries « ‹ 1 of 9 › »

Canet G, Monteiro FDG, Rocaboy E, Diego-Diaz S, Khelaifia B, Kim J, Valencia D, Yin A, Wu HT, Howell J, Blank E, Laliberté F, Fortin N, Boscher E, Fereydouni-Forouzandeh P, Champagne S, Guisle I, Hébert S, Pernet V, Liu H, Lu W, Debure L, Rapoport D, Ayappa I, Varga A, Parekh A, Osorio R, Lacroix S, Lucey B, Blessing E, Planel E

Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans

Journal Article

Res Sq, 2024.

Abstract | Links:

Nateghi B, Keraudren R, Boulay G, Bazin M, Goupil C, Canet G, Loiselle A, St-Amour I, Planel E, Soulet D, Hébert SS

Beneficial effects of miR-132/212 deficiency in the zQ175 mouse model of Huntington's disease

Journal Article

Front Neurosci, 18 , 2024.

Abstract | Links:

Kompotis K, Mang GM, Hubbard J, Jimenez S, Emmenegger Y, Polysopoulos C, Hor CN, Wigger L, Hébert SS, Mongrain V, Franken P

Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner

Journal Article

Proc Natl Acad Sci U S A, 121 (3), 2024.

Abstract | Links:

Canet G, Gratuze M, Zussy C, Bouali ML, Diaz SD, Rocaboy E, Laliberté F, El Khoury NB, Tremblay C, Morin F, Calon F, Hébert SS, Julien C, Planel E

Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice

Journal Article

Neurobiol Dis, 198 , 2024.

Abstract | Links:

Zhang Y, Béland LC, Roussel S, Bertrand N, Hébert SS, Vallières L

Optimization of a lipid nanoparticle-based protocol for RNA transfection into primary mononuclear phagocytes

Journal Article

J Leukoc Biol, 115 (6), 2024.

Abstract | Links:

Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, Bennett DA, Hébert SS, Calon F

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease

Journal Article

Acta Neuropathol Commun, 11 (1), 2023.

Abstract | Links:

Petry S, Nateghi B, Keraudren R, Sergeant N, Planel E, Hébert SS, St-Amour I

Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain

Journal Article

Neuroscience, 518 , 2023.

Abstract | Links:

Canet G, Rocaboy E, Laliberté F, Boscher E, Guisle I, Diego-Diaz S, Fereydouni-Forouzandeh P, Whittington RA, Hébert SS, Pernet V, Planel E

Temperature-induced Artifacts in Tau Phosphorylation: Implications for Reliable Alzheimer's Disease Research

Journal Article

Exp Neurobiol, 32 (6), 2023.

Abstract | Links:

Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, Bennett DA, Hébert SS, Calon F

Correction to: Higher angiotensin‑converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease

Journal Article

Acta Neuropathol Commun, 11 (1), 2023.

| Links:

Guisle I, Canet G, Pétry S, Fereydouni-Forouzandeh P, Morin F, Kérauden R, Whittington RA, Calon F, Hébert SS, Planel E

Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia

Journal Article

Neurobiol Aging, 113 , 2022.

Abstract | Links:

83 entries « ‹ 1 of 9 › »
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  • Consortium pour l’identification précoce de la maladie d’Alzheimer (CIMA-Q) : renforcer l’intersectorialité, le rayonnement et le potentiel de découverte., from 2024-04-01 to 2028-03-31
  • Importance of non-canonical microRNAs in the mammalian brain, from 2020-04-01 to 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2022-04-01 to 2027-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease, from 2020-03-01 to 2025-03-31
  • Vascular MicroRNA-212 in CAA and Alzheimer's disease, from 2023-09-22 to 2025-08-31
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