Dr. Sébastien Fortin PhD is a regular researcher at the Centre de recherche du CHU de Québec-Laval University, Director of a pharmaceutical chemistry laboratory located at the Hôpital Saint-François d’Assise, and Associate Professor at Laval University’s School of Pharmacy. He is author and co-author of 28 publications and co-inventor of 3 patents on the technologies that he develops. Dr. Fortin is the recipient of several awards and honors, including the Jean-François St-Denis Fellowship in Cancer Research from the Canadian Institutes of Health Research (CIHR) and the 2011 award for the best doctorate in cotutelle awarded by the Ministère des Relations internationales and the Consulat général de France à Québec. His research focuses on the design and development of new anticancer agents for use in personalized medicine.

Development of new drugs for personalized cancer chemotherapy

In Canada, cancer is the leading cause of death, followed only by cardiovascular diseases. Cancer is therefore a major public health problem. Despite recent medical breakthroughs, the ability to cure all cancer patients remains elusive. Consequently, we need to develop new treatments that will be more efficient, and more selective against cancer tumors, with the aim of improving the life expectancy and the quality of life of cancer patients. The aim of my research program is to design and prepare new anticancer agents exhibiting optimal biopharmaceutical and anticancer properties suitable for preclinical and clinical studies. My research themes are divided in two parts: 1) development of new inhibitors of DNA repair and replication mechanisms and 2) development of new inhibitors targeting cells deficient in homologous recombination. My research programs involve and focus on several interrelated and complementary disciplines, including molecular design and modeling, medicinal chemistry, cell biology, molecular pharmacology, and animal experimentation. The outcomes of these projects will contribute to the development of new, efficient and personalized anticancer treatments.

Hôpital Saint-François d'Assise
10, rue de l'Espinay
D0-705C
Québec, Québec
Canada G1L 3L5
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Gagné-Boulet M, Bouzriba C, Chavez Alvarez AC, Fortin S

Rationale, synthesis and biological evaluation of substituted 1-(4-(phenylthio)phenyl)imidazolidin-2-one, urea, thiourea and amide analogs and derivatives designed to target the colchicine-binding site

Journal Article

J Mol Struct, 1259 , 2022.

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Bouzriba C, Chavez Alvarez AC, Gagné-Boulet M, Ouellette V, Lacroix J, Côté MF, C-Gaudreault R, Fortin S

Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation

Journal Article

Eur J Med Chem, 229 , 2022.

Abstract | Links:

Gagné-Boulet M, Bouzriba C, Chavez Alvarez AC, Fortin S

Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin-2-one moiety of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates

Journal Article

Chem Biol Drug Des, 99 (2), 2022.

Abstract | Links:

Bouchard M, Tremblay T, Paré-Lacroix MP, Gagné-Boulet M, Fortin S, Giguère D

Synthetic development of sugar amino acid oligomers towards novel podophyllotoxin analogues

Journal Article

Bioorg Med Chem, 52 , 2021.

Abstract | Links:

Gagne-Boulet M, Bouzriba C, Chavez Alvarez AC, Fortin S

Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site

Journal Article

Eur J Med Chem, 213 , 2021.

Abstract | Links:

Bouzriba C, Larcher L, Gagné-Boulet M, Fortin S

N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors

Journal Article

Bioorg Med Chem, 28 (22), 2020.

Abstract | Links:

Zarifi Khosroshahi M, Corin Chavez Alvarez A, Gagne-Boulet M, C-Gaudreault R, Gobeil S, Fortin S

Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs

Journal Article

J Pharm Pharmacol, 72 (2), 2020.

Abstract | Links:

Couillard-Montminy V, Gagnon PY, Fortin S, Cote J

Effectiveness of adjuvant carboplatin-based chemotherapy compared to cisplatin in non-small cell lung cancer

Journal Article

J Oncol Pharm Pract, 25 (1), 2019.

Abstract | Links:

Denavit V, Laine D, Bouzriba C, Shanina E, Gillon E, Fortin S, Rademacher C, Imberty A, Giguere D

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions

Journal Article

Chemistry, 25 (17), 2019.

Abstract | Links:

Vadhadiya PM, Jean MA, Bouzriba C, Tremblay T, Lague P, Fortin S, Boukouvalas J, Giguere D

Diversity-Oriented Synthesis of Diol-Based Peptidomimetics as Potential HIV Protease Inhibitors and Antitumor Agents

Journal Article

Chembiochem, 2018.

Abstract | Links:

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Active projects

  • Characterisation of the molecular structure and function of topoisomerase I using anticancer agents as molecular probes acting in a new allosteric binding-site, from 2016-04-01 to 2023-03-31
  • Conception de nouveaux agents anticancéreux ciblant les mécanismes, from 2018-07-01 to 2022-06-30
  • Conception de nouveaux agents anticancéreux ciblant les mécanismes de réparation et de réplication de l'ADN en vue de leur utilisation en médecine personnalisée, from 2018-07-01 to 2022-06-30
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • Pharmacological optimization of OpKemo, a silica-based nanoparticle platform for oncology, from 2022-01-31 to 2024-03-31

Recently finished projects

  • Appui financier du Fonds de recherche de l’Hôpital Saint-François d'Assise pour le support de doctorants.es au laboratoire du Dr Sébastien Fortin, from 2020-05-01 to 2022-04-30
  • Les phénylureidobenzènesulfonates, une nouvelle thérapie de différenciation pour le traitement de la leucémie myéloïde aiguë : preuve de concept, from 2020-02-01 to 2022-01-31
Data provided by the Université Laval research projects registery