Dr. Samer Hussein is a researcher at the CHU Research Centre of Quebec – Laval University, and is part of the St-Patrick group of research in fundamental oncology. He is also Assistant Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine, Laval University.

His research aims to understand the molecular mechanisms that establish and regulate pluripotent cell states, particularly the role of long non-coding RNAs in gene networks, as well as the transcriptional events responsible for cancer initiation and progression.

Defining gene networks and their interactions that govern pluripotent states

Pluripotency is defined as the ability of a cell to generate all the cell types found in an organism. The three transcription factors Oct4, Sox2, and Nanog represent the central pillars of the gene regulatory network associated with the maintenance of a pluripotent state. Through cellular models of pluripotency and reprogramming, and the use of high-throughput technologies (proteomics, RNA-seq and ChIP-seq), this project aims to understand how interactions between transcription factors of pluripotency and chromatin regulators determine cell fate and cell transition to specific lineages in embryonic development, as well as cancer development.

Defining the role of certain long non-coding RNAs in cell identity

Long non-coding RNAs (lncRNA) constitute an entire class of RNA, characterized by the fact that they do not encode any known protein and that they are composed of at least 200 base pairs. LncRNAs are implicated in gene regulation and maintenance of cellular identity, but their mechanism of action involved in the establishment of pluripotency remains unknown. The objective of this project is to understand the role of lncRNAs in the regulation of pluripotent states and the reprogramming of embryonic stem cells.

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Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Journal Article

Cell Rep, 39 (11), 2022.

Abstract | Links:

Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J

MRG proteins are shared by multiple protein complexes with distinct functions

Journal Article

Mol Cell Proteomics, 2022.

Abstract | Links:

Varga BV, Faiz M, Pivonkova H, Khelifi G, Yang H, Gao S, Linderoth E, Zhen M, Karadottir RT, Hussein SM, Nagy A

Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

Journal Article

Nat Commun, 13 (1), 2022.

Abstract | Links:

Isaev K, Jiang L, Wu S, Lee CA, Watters V, Fort V, Tsai R, Coutinho FJ, Hussein SMI, Zhang J, Wu J, Dirks PB, Schramek D, Reimand J

Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

Journal Article

Cell Rep, 37 (3), 2021.

Abstract | Links:

Fort V, Khelifi G, Hussein SMI

Long non-coding RNAs and transposable elements: A functional relationship

Journal Article

Biochim Biophys Acta Mol Cell Res, 1868 (1), 2021.

Abstract | Links:

Khelifi G, Hussein SMI

A New View of Genome Organization Through RNA Directed Interactions

Journal Article

Front Cell Dev Biol, 8 , 2020.

| Links:

Subramania S, Gagné LM, Campagne S, Fort V, O'Sullivan J, Mocaer K, Feldmüller M, Masson JY, Allain FHT, Hussein SM, Huot MÉ

SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing

Journal Article

Nucleic Acids Res, 47 (8), 2019.

Abstract | Links:

Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Journal Article

Cell Res, 27 (11), 2017.

Abstract | Links:

Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH

Irx3 is required for postnatal maturation of the mouse ventricular conduction system

Journal Article

Sci Rep, 6 , 2016.

Abstract | Links:

Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PW

CD24 tracks divergent pluripotent states in mouse and human cells

Journal Article

Nat Commun, 6 , 2015.

Abstract | Links:

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Active projects

  • Direct lineage reprogramming of astrocytes to new oligodendrocytes for the treatment of demyelinating disease, from 2022-04-01 to 2025-01-31
  • Repairing the dopaminergic circuits in Parkinson disease using synucleinopathy resistant neurones grafting, from 2022-04-01 to 2024-03-31
  • Transcription factor stoichiometry defines distinct pluripotent states, from 2016-04-01 to 2023-03-31

Recently finished projects

  • Étude de criblage sur la reprogrammation du métabolisme, du micro-environnement tumoral et des cellules souches cancéreuses dans le médulloblastome, from 2021-05-01 to 2022-04-30
  • Les réseaux d’interactions moléculaires dans les états de pluripotence différents, from 2017-07-01 to 2021-06-30
  • Les réseaux d’interactions moléculaires dans les états de pluripotence différents, from 2017-07-01 to 2020-06-30
  • The role of long non-coding RNAs in defining pluripotent stem cell states, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery