Dr. Samer Hussein is a researcher at the CHU Research Centre of Quebec – Laval University, and is part of the St-Patrick group of research in fundamental oncology. He is also Assistant Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine, Laval University.

His research aims to understand the molecular mechanisms that establish and regulate pluripotent cell states, particularly the role of long non-coding RNAs in gene networks, as well as the transcriptional events responsible for cancer initiation and progression.

Defining gene networks and their interactions that govern pluripotent states

Pluripotency is defined as the ability of a cell to generate all the cell types found in an organism. The three transcription factors Oct4, Sox2, and Nanog represent the central pillars of the gene regulatory network associated with the maintenance of a pluripotent state. Through cellular models of pluripotency and reprogramming, and the use of high-throughput technologies (proteomics, RNA-seq and ChIP-seq), this project aims to understand how interactions between transcription factors of pluripotency and chromatin regulators determine cell fate and cell transition to specific lineages in embryonic development, as well as cancer development.

Defining the role of certain long non-coding RNAs in cell identity

Long non-coding RNAs (lncRNA) constitute an entire class of RNA, characterized by the fact that they do not encode any known protein and that they are composed of at least 200 base pairs. LncRNAs are implicated in gene regulation and maintenance of cellular identity, but their mechanism of action involved in the establishment of pluripotency remains unknown. The objective of this project is to understand the role of lncRNAs in the regulation of pluripotent states and the reprogramming of embryonic stem cells.

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Latest news

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Gonzalez-Nolde S, Schweiger CJ, Davis EER, Manzoni TJ, Hussein SMI, Schmidt TA, Cone SG, Jay GD, Parreno J

The Actin Cytoskeleton as a Regulator of Proteoglycan 4

Journal Article

Cartilage, 2024.

Abstract | Links:

Ledoux N, Lelong EIJ, Simard A, Hussein S, Adjibade P, Lambert JP, Mazroui R

The Identification of Nuclear FMRP Isoform Iso6 Partners

Journal Article

Cells, 12 (24), 2023.

Abstract | Links:

Ledoux N, Gauthier-Naud W, Lavoie O, Watters V, Hussein S, Adjibade P, Mazroui R

The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges

Journal Article

Mol Biol Cell, 34 (5), 2023.

Abstract | Links:

Gao Y, Guitton-Sert L, Dessapt J, Coulombe Y, Rodrigue A, Milano L, Blondeau A, Larsen NB, Duxin JP, Hussein S, Fradet-Turcotte A, Masson JY

A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Journal Article

Nat Commun, 14 (1), 2023.

Abstract | Links:

Varga BV, Faiz M, Pivonkova H, Khelifi G, Yang H, Gao S, Linderoth E, Zhen M, Karadottir RT, Hussein SM, Nagy A

Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

Journal Article

Nat Commun, 13 (1), 2022.

Abstract | Links:

Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J

MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions

Journal Article

Mol Cell Proteomics, 21 (7), 2022.

Abstract | Links:

Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Journal Article

Cell Rep, 39 (11), 2022.

Abstract | Links:

Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

Journal Article

NAR Cancer, 4 (4), 2022.

Abstract | Links:

Elbaz J, Puri MC, Faiz M, Bang KWA, Nguyen L, Makovoz B, Gertsenstein M, Hussein SMI, Zandstra PW, Briollais L, Shakiba N, Nagy A

Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency

Journal Article

Proc Natl Acad Sci U S A, 119 (49), 2022.

Abstract | Links:

Khelifi G, Chow T, Whiteley J, Fort V, Humphreys BD, Hussein SMI, Rogers IM

Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse

Journal Article

Sci Rep, 12 (1), 2022.

Abstract | Links:

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Active projects

  • Direct lineage reprogramming of astrocytes to new oligodendrocytes for the treatment of demyelinating disease, from 2022-04-01 to 2026-01-31
  • Exploration des interactions fonctionnelles des longs ARNs non-codants dans le développement embryonnaire et le cancer, from 2022-07-01 to 2025-06-30
  • Implications of RNA isoform diversity on gene function and cellular plasticity, from 2024-04-01 to 2029-03-31
  • Unraveling the functional domains of a novel pluripotency-associated lncRNA, from 2023-04-01 to 2028-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Repairing the dopaminergic circuits in Parkinson disease using synucleinopathy resistant neurones grafting, from 2022-04-01 to 2024-03-31
  • Transcription factor stoichiometry defines distinct pluripotent states, from 2016-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery