Dr. De Serres received his MD from University of Montreal and FRCPC in Internal Medicine and Nephrology following residency at Laval University in Canada. He then completed a 3-year Research Fellowship in transplant immunology at the Brigham and Women’s Hospital and received a Master of Epidemiology from Harvard School of Public Health. He is currently Associate Professor of Medicine at Laval University and Clinician-Scientist Junior II FRQS scholar.

At the national level, he has served as Chair of the 2018 Canadian Society of Transplantation Scientific Committee, in charge of organizing the Canadian Transplant Summit. At the international level, he has been elected as Executive Member of American Society of Transplantation Transplant Diagnostic Committee for a 2-year term, from 2016 to 2018. He also served as a member of the AST Transplantation and Immunology Research Network Scientific Committee from 2015 to 2018.

His research program focuses on cell-based assays to identify over-immunosuppression and on the mechanisms of antibody-mediated rejection. Since 2011, he has received continuous funding from different agencies including Kidney Foundation of Canada, CIHR, CFI and FRQS. His lab is currently funded by a CIHR Project Scheme grant and he is co-investigator and collaborator on several multicenter projects, including the CIHR-funded TMCT-04 trial and the Genome Canada-funded Can PREVENT AMR study.

L'Hôtel-Dieu de Québec
10, rue McMahon
2879
Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 16839
Sacha.DeSerres@crchudeque...

Latest news

67 entries « ‹ 1 of 7 › »

Desgagnés JS, Désy O, Thivierge MP, Marcoux M, Béland S, De Serres SA

SARS-Cov-2 Antibody Levels That Confer Immune Protection Based on Neutralization of the Omicron Variant

Journal Article

Transplantation, 2023, ISSN: 0041-1337.

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Ho J, Schaub S, Jackson AM, Balshaw R, Carroll R, Cun S, De Serres SA, Fantus D, Handschin J, Hönger G, Jevnikar AM, Kleiser M, Lee JH, Li Y, Nickerson P, Pei R, Pochinco D, Shih R, Trinh M, Wang J, Nguyen J, Knechtle S

Multicenter Validation of a Urine CXCL10 Assay for Noninvasive Monitoring of Renal Transplants

Journal Article

Transplantation, 2023, ISSN: 0041-1337.

Abstract | Links:

Béland S, Désy O, El Fekih R, Marcoux M, Thivierge MP, Thivierge MP, Desgagné JS, Latulippe E, Riopel J, Wagner E, Rennke HG, Weins A, Yeung M, Lapointe I, Azzi J, De Serres SA

Expression of Class II Human Leukocyte Antigens on Human Endothelial Cells Shows High Interindividual and Intersubclass Heterogeneity

Journal Article

J Am Soc Nephrol, 2023.

Abstract | Links:

Ouellet G, Houde I, Riopel J, Latulippe E, Douville P, Lesage J, Côté I, Lapointe I, De Serres SA

The Progression of Interstitial Fibrosis and Tubular Atrophy at 6 Months Is an Independent Predictor of Poor Graft Outcomes in Kidney Transplant Recipients

Journal Article

Transplant Direct, 8 (12), 2022.

Abstract | Links:

Hall VG, Solera JT, Al-Alahmadi G, Marinelli T, Cardinal H, Poirier C, Huard G, Prasad GVR, De Serres SA, Isaac D, Mainra R, Lamarche C, Sapir-Pichhadze R, Gilmour S, Humar A, Kumar D

Gravité de la COVID-19 chez les receveurs d’une transplantation d’organe plein au Canada, 2020–2021 : étude de cohorte prospective multicentrique

Journal Article

CMAJ, 194 (46), 2022.

| Links:

Fowler EA, Bell K, Burns K, Chiazzese A, DeSerres SA, Foster BJ, Hartwig S, Herrington G, James MT, Jensen V, Jones N, Kidston S, Lemay S, Levin A, MacPhee A, McCutcheon S, Ravani P, Samuel S, Scholey J, Takano T, Tangri N, Verdin N, Alexander RT, Clase CM

Involving Patient Partners in the KRESCENT Peer Review: Intent, Process, Challenges, and Opportunities

Journal Article

Can J Kidney Health Dis, 9 , 2022.

Abstract | Links:

Hall VG, Solera JT, Al-Alahmadi G, Marinelli T, Cardinal H, Poirier C, Huard G, Prasad GVR, De Serres SA, Isaac D, Mainra R, Lamarche C, Sapir-Pichhadze R, Gilmour S, Humar A, Kumar D

Severity of COVID-19 among solid organ transplant recipients in Canada, 2020-2021: a prospective, multicentre cohort study

Journal Article

CMAJ, 194 (33), 2022.

Abstract | Links:

Hall VG, Al-Alahmadi G, Solera JT, Marinelli T, Cardinal H, Prasad GVR, De Serres SA, Isaac D, Mainra R, Lamarche C, Sapir-Pichhadze R, Gilmour S, Matelski J, Humar A, Kumar D

Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared With Vaccinated Solid Organ Transplant Recipients: A Propensity Matched Cohort Study

Journal Article

Transplantation, 106 (8), 2022.

Abstract | Links:

Hildebrand AM, Barua M, Barbour SJ, Tennankore KK, Cattran DC, Takano T, Lam P, De Serres SA, Samanta R, Hladunewich MA, Fairhead T, Poyah P, Bush DD, MacLaren B, Sparkes D, Boll P, Jauhal A, John R, Avila-Casado C, Reich HN

The Canadian Glomerulonephritis Registry (CGNR) and Translational Research Initiative: Rationale and Clinical Research Protocol

Journal Article

Can J Kidney Health Dis, 9 , 2022.

Abstract | Links:

Jahromi M, Al-Otaibi T, Ashry Gheith O, Farouk Othman N, Mahmoud T, Nair P, A-Halim M, Aggarwal P, Messenger G, Chu P, De Serres SA, Azzi JR

Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

67 entries « ‹ 1 of 7 › »
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Active projects

  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, from 2019-10-01 to 2024-09-30
  • Chaire de recherche en néphrologie AMGEN, from 2019-01-01 to 2024-04-30
  • Development and validation of a cell-based assay to identify over-immunosuppression in kidney transplant recipients, from 2019-10-01 to 2023-09-30
  • Mieux comprendre la réponse allo-immunitaire chez le greffé rénal afin de personnaliser l'immunothérapie, from 2020-07-01 to 2024-06-30
  • Rôle des cellules dendritiques dans l'immunologie de la transplantation., from 2015-01-01 to 2024-05-31

Recently finished projects

  • A cell-based assay to measure immune competence in SARS-CoV-2 infection and vaccination, from 2021-06-01 to 2022-05-31
  • A randomized controlled effectiveness trial of urine CXCL10 chemokine monitoring post-renal transplant, from 2016-07-01 to 2021-06-30
  • Aldosterone antagonism and enhanced Clearance for Health Improvement EValuation in End-stage renal disease (ACHIEVE) Trial, from 2016-07-01 to 2022-06-30
  • Mieux comprendre les mécanismes immunologiques du rejet chronique chez le greffé rénal afin d'améliorer le diagnostic et la prise en charge thérapeutique, from 2018-07-01 to 2022-06-30
  • Precision Medicine CanPREVENT AMR: Applying Precision Medicine Technologies in Canada to Prevent Antibody Mediated Rejection and Premature Kidney Transplant Loss, from 2018-04-01 to 2022-03-31
  • Prix Louis Belleau, from 2020-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery