Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.

The research

Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the « Spinde Assembly Checkpoint » or « SAC » kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.

Our research focuses on the following questions:

  1. What are the mechanisms of activation and inactivation of SAC kinases?
  2. What are the endogenous substrates of SAC kinases?
  3. Is SAC differentially regulated in cell lines with chromosomal instability?
  4. How does aneuploidy contribute to cancer?

We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
34 entries « 4 of 4 »

Santamaria A, Wang B, Elowe S, Malik R, Zhang F, Bauer M, Schmidt A, Sillje HH, Korner R, Nigg EA

The Plk1-dependent phosphoproteome of the early mitotic spindle

Journal Article

Mol Cell Proteomics, 10 (1), 2011.

Abstract | Links:

Dou Z, von Schubert C, Korner R, Santamaria A, Elowe S, Nigg EA

Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1

Journal Article

PLoS One, 6 (4), 2011.

Abstract | Links:

Elowe S

Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint

Journal Article

Mol Cell Biol, 31 (15), 2011.

Abstract | Links:

Elowe S, Dulla K, Uldschmid A, Li X, Dou Z, Nigg EA

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1

Journal Article

J Cell Sci, 123 (Pt 1), 2010.

Abstract | Links:

34 entries « 4 of 4 »
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Active projects

  • Exploring A Novel Signalling Pathway in Cilia formation and Ciliopathies, from 2023-02-21 to 2024-02-21
  • Functional and evolutionary characterization of the transcription factor ZNF768, from 2023-02-28 to 2024-03-31
  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
  • The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation, from 2023-04-01 to 2028-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2023-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
  • Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
  • Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery