Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.

The research

Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the « Spinde Assembly Checkpoint » or « SAC » kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.

Our research focuses on the following questions:

  1. What are the mechanisms of activation and inactivation of SAC kinases?
  2. What are the endogenous substrates of SAC kinases?
  3. Is SAC differentially regulated in cell lines with chromosomal instability?
  4. How does aneuploidy contribute to cancer?

We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46252
+1 418-654-2783
Sabine.Elowe@crchudequebe...

Latest news

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Wang LH, Yen CJ, Li TN, Elowe S, Wang WC

Sgo1 is a potential therapeutic target for hepatocellular carcinoma

Journal Article

Oncotarget, 6 (4), 2015.

Abstract | Links:

Asghar A, Lajeunesse A, Dulla K, Combes G, Thebault P, Nigg EA, Elowe S

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

Journal Article

Nat Commun, 6 , 2015.

Abstract | Links:

Fuchs M, Luthold C, Guilbert SM, Varlet AA, Lambert H, Jette A, Elowe S, Landry J, Lavoie JN

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis

Journal Article

PLoS Genet, 11 (10), 2015.

Abstract | Links:

Magron A, Elowe S, Carreau M

The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation

Journal Article

PLoS One, 10 (10), 2015.

Abstract | Links:

Ghongane P, Kapanidou M, Asghar A, Elowe S, Bolanos-Garcia VM

The dynamic protein Knl1 - a kinetochore rendezvous

Journal Article

J Cell Sci, 127 (Pt 16), 2014.

Abstract | Links:

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Journal Article

Biochem J, 457 (2), 2014.

Abstract | Links:

Kasahara K, Goto H, Izawa I, Kiyono T, Watanabe N, Elowe S, Nigg EA, Inagaki M

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition

Journal Article

Nat Commun, 4 , 2013.

Abstract | Links:

Rojas AM, Santamaria A, Malik R, Jensen TS, Korner R, Morilla I, de Juan D, Krallinger M, Hansen DA, Hoffmann R, Lees J, Reid A, Yeats C, Wehner A, Elowe S, Clegg AB, Brunak S, Nigg EA, Orengo C, Valencia A, Ranea JA

Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology

Journal Article

PLoS One, 7 (3), 2012.

Abstract | Links:

Lee S, Thebault P, Freschi L, Beaufils S, Blundell TL, Landry CR, Bolanos-Garcia VM, Elowe S

Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases

Journal Article

J Biol Chem, 287 (8), 2012.

Abstract | Links:

Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Journal Article

Biochem J, 448 (3), 2012.

Abstract | Links:

34 entries « ‹ 3 of 4 › »
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Active projects

  • Exploring A Novel Signalling Pathway in Cilia formation and Ciliopathies, from 2023-02-21 to 2024-02-21
  • Functional and evolutionary characterization of the transcription factor ZNF768, from 2023-02-28 to 2024-03-31
  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
  • The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation, from 2023-04-01 to 2028-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2023-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
  • Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
  • Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery