Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.

The research

Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the « Spinde Assembly Checkpoint » or « SAC » kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.

Our research focuses on the following questions:

  1. What are the mechanisms of activation and inactivation of SAC kinases?
  2. What are the endogenous substrates of SAC kinases?
  3. Is SAC differentially regulated in cell lines with chromosomal instability?
  4. How does aneuploidy contribute to cancer?

We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
34 entries « 2 of 4 »

Gama Braga L, Cisneros AF, Mathieu MM, Clerc M, Garcia P, Lottin B, Garand C, Thebault P, Landry CR, Elowe S

BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment

Journal Article

Cell Rep, 33 (7), 2020.

Abstract | Links:

Dos Santos A, Elowe S

Moonlighting at the Centrosome: RXRα Turns to Plk1

Journal Article

Dev Cell, 55 (6), 2020.

Abstract | Links:

Dou Z, Prifti DK, Gui P, Liu X, Elowe S, Yao X

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Journal Article

Cells, 8 (3), 2019.

Abstract | Links:

Elowe S

Editorial: Novel Insights Into the Multifaceted Mitotic Kinases

Journal Article

Front Cell Dev Biol, 7 , 2019.

| Links:

Combes G, Barysz H, Garand C, Gama Braga L, Alharbi I, Thebault P, Murakami L, Bryne DP, Stankovic S, Eyers PA, Bolanos-Garcia VM, Earnshaw WC, Maciejowski J, Jallepalli PV, Elowe S

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

Journal Article

Curr Biol, 28 (6), 2018.

Abstract | Links:

Boutchueng-Djidjou M, Belleau P, Bilodeau N, Fortier S, Bourassa S, Droit A, Elowe S, Faure RL

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes

Journal Article

PLoS One, 13 (10), 2018.

Abstract | Links:

Jacquet K, Banerjee SL, Chartier FJM, Elowe S, Bisson N

Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis

Journal Article

Mol Cell Proteomics, 17 (10), 2018.

Abstract | Links:

Elowe S

Tyr(less) kinase signaling during mitosis

Journal Article

Cell Cycle, 16 (8), 2017.

Abstract | Links:

Combes G, Alharbi I, Braga LG, Elowe S

Playing polo during mitosis: PLK1 takes the lead

Journal Article

Oncogene, 36 (34), 2017.

Abstract | Links:

Caron D, Byrne DP, Thebault P, Soulet D, Landry CR, Eyers PA, Elowe S

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)

Journal Article

Sci Signal, 9 (458), 2016.

Abstract | Links:

34 entries « 2 of 4 »
Signaler des ajouts ou des modifications

Active projects

  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
  • Novel phosphotyrosine signalling pathways during mitosis, from 2024-04-01 to 2029-03-31
  • Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2025-03-31
  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31
  • Régulation de la morphogenèse tissulaire par la signalisation dépendante des récepteurs EPH et des ligands éphrines, from 2024-04-01 to 2027-03-31
  • Régulation dynamique de la couronne fibreuse dans l'espace et le temps, from 2024-04-01 to 2027-03-31
  • The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation, from 2023-04-01 to 2028-03-31
  • Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2025-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Exploring A Novel Signalling Pathway in Cilia formation and Ciliopathies, from 2023-02-21 to 2024-02-21
  • Functional and evolutionary characterization of the transcription factor ZNF768, from 2023-02-28 to 2024-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
  • Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
  • ZNF768 PROTEIN HOMEOSTASIS: at the interface of controlled and uncontrolled growth, from 2024-03-18 to 2024-06-09
Data provided by the Université Laval research projects registery