Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.
The research
Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the « Spinde Assembly Checkpoint » or « SAC » kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.
Our research focuses on the following questions:
- What are the mechanisms of activation and inactivation of SAC kinases?
- What are the endogenous substrates of SAC kinases?
- Is SAC differentially regulated in cell lines with chromosomal instability?
- How does aneuploidy contribute to cancer?
We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
Latest news
- IRSC : Un financement de près de 16 millions de dollars pour 34 projets de recherche 2023-03-07
- 13 chercheurs du Centre de recherche du CHU de Québec-Université Laval obtiennent 7,6M$ au programme Projet des IRSC 2018-01-26
- 10 chercheurs du Centre de recherche du CHU de Québec se sont mérité une bourse du Fonds Merck-Université Laval 2016-09-16
- Calvo, EvaMaster studentCHUL+1 418-525-4444, extension 42296eva.calvo@crchudequebec.ulaval.caevcal2@ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Devillers, RomainDoctoral studentCHUL+1 418-525-4444, extension 42296romain.devillers@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Dos Santos, AlexsandroDoctoral studentCHUL+1 418-525-4444, extension 42296alexsandro.dos-santos@crchudequebec.ulaval.caalexsandro.santos.1@ulaval.ca
2705, boul. Laurier
T3-67
Québec, Québec
Canada G1V 4G2 - Doucet, ChristianEmployeeCHUL+1 418-525-4444christian.doucet@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3
Québec, QC
Canada G1V 4G2 - Garand, ChantalEmployeeCHUL+1 418-525-4444, extension 42296Chantal.Garand@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2 - Ouellet-Boutin, KatherynDoctoral studentCHUL+1 418-525-4444, extension 42296katheryn.ouellet-boutin.1@ulaval.cakatheryn.ouellet-boutin@crchudequebec.ulaval.ca
2705, boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Prifti, DiogjenaDoctoral studentCHUL+1 418-525-4444, extension 42296diogjena.alkaterini-prifti@crchudequebec.ulaval.cadiogjena.prifti.1@ulaval.ca
2705 Boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2 - Saini, Pawan KumarDoctoral studentCHUL+1 418-525-4444, extension 42296pawan-kumar.saini.1@ulaval.capawan.kumar-saini@crchudequebec.ulaval.ca
2705 Boulevard Laurier
T3-67
Québec, QC
Canada G1V 4G2
BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment
Journal ArticleCell Rep, 33 (7), 2020.
Moonlighting at the Centrosome: RXRα Turns to Plk1
Journal ArticleDev Cell, 55 (6), 2020.
Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
Journal ArticleCells, 8 (3), 2019.
Editorial: Novel Insights Into the Multifaceted Mitotic Kinases
Journal ArticleFront Cell Dev Biol, 7 , 2019.
Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis
Journal ArticleMol Cell Proteomics, 17 (10), 2018.
A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes
Journal ArticlePLoS One, 13 (10), 2018.
Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint
Journal ArticleCurr Biol, 28 (6), 2018.
Tyr(less) kinase signaling during mitosis
Journal ArticleCell Cycle, 16 (8), 2017.
Playing polo during mitosis: PLK1 takes the lead
Journal ArticleOncogene, 36 (34), 2017.
Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)
Journal ArticleSci Signal, 9 (458), 2016.
Active projects
- Exploring A Novel Signalling Pathway in Cilia formation and Ciliopathies, from 2023-02-21 to 2024-02-21
- Functional and evolutionary characterization of the transcription factor ZNF768, from 2023-02-28 to 2024-03-31
- Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
- The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation, from 2023-04-01 to 2028-03-31
Recently finished projects
- Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
- Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2023-03-31
- PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
- Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
- Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2022-03-31