Dr. Roxane Pouliot is a regular researcher at the CHU Research Centre of Quebec-Laval University, and Professor at the Faculty of Pharmacy of Laval University. As a regular member, she is also part of the Centre for Advanced Materials Research (CAMaR), as well as the Centre Québécois on Functional Materials (CQMF). Her research interests focus on a better understanding of the structures and functions of skin tissue through advanced models of tissue reconstruction. Her team recently developed an immunocompetent psoriatic skin replacement model reconstructed from human cells, a major breakthrough in this area.
Dr. Pouliot is the recipient of Laval University’s 2016 Graduate Teaching and Coaching Award.
Understanding the complexity of structures and functions of skin tissue
In vitro skin diffusion tests are one of the first steps in the development of a transdermal drug. To this end, a robust model of cutaneous biomaterial is necessary for the precise study of the diffusion mechanisms of therapeutic molecules. Advanced lipidomic characterization of tissue-engineered samples is essential for understanding the skin lipid domain, which is complex and poorly reproduced in vitro. However, the biomimetic quality currently developed within our research team allows us to consider improving the models to obtain the qualities found within a native skin, whether healthy or pathological.
Modelling psoriasis and developing new pharmacological strategies
Cutaneous diseases such as psoriasis are complex diseases whose development and persistence involve several cellular processes and cell types. In recent years, our research team has developed a world-unique model of reconstructed psoriatic skin. Through tissue engineering, it becomes possible to reconstruct, according to the self-assembly method, a completely autologous pathological skin, that is to say without exogenous material, and composed of both a dermis and an epidermis. This model of pathological skin provides us with the opportunity to study separately the players involved in the development of psoriasis, and therefore becomes a powerful tool in the mechanistic analysis of this complex pathology. Distinctly, the latter is three-dimensional, designed from psoriatic human cells, in addition to developing in a highly physiological environment.
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Effects of serum-free culture at the air-liquid interface in a human tissue-engineered skin substituteJournal Article
Tissue Eng Part A, 17 (7-8), 2011.
Effects of retinoic acid on keratinocyte proliferation and differentiation in a psoriatic skin modelJournal Article
Tissue Eng Part A, 17 (13-14), 2011.
Markers for an in vitro skin substituteBook Chapter
Maguire T, Novik E (Ed.): Alternative technologies to animal testing, pp. 183-203, Boston, MA, Artech House, 2010.
In vivo and in vitro models of psoriasisBook Chapter
Eberli Daniel (Ed.): Tissue Engineering, pp. 359-382, 2010.
How to achieve early vascularization of tissue-engineered skin substitutesBook Chapter
Sen ChandanK (Ed.): Advances in Wound Care, 1 , pp. 445-450, New Rochelle, NY, Mary Ann Liebert, Inc., 2010.
De la peau en laboJournal Article
Cellular interactions in vitro: psoriatic keratinocytes enhance T lymphocyte survivalJournal Article
16 , 2010.
Antioxidant, toxicological and antiproliferative properties of Canadian polyphenolic extracts on normal and psoriatic keratinocytesJournal Article
J Ethnopharmacol, 132 (1), 2010.
In vitro: un nouveau modèle cutané pour des traitements plus efficaces du psoriasisJournal Article
44 (22), 2009.
Development of an in vitro psoriatic skin model by tissue engineeringJournal Article
J Dermatol Sci, 53 (1), 2009.
- Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
- Comprendre la complexité du domaine lipidique cutané, from 2019-04-01 to 2027-03-31
- Nouvelles options thérapeutiques pour les patients atteints de psoriasis, from 2019-10-01 to 2024-09-30
Recently finished projects
- Étude de l'impact de l'innervation cutanée dans le Psoriasis, from 2018-04-01 to 2023-03-31