Dr. Roxane Pouliot is a regular researcher at the CHU Research Centre of Quebec-Laval University, and Professor at the Faculty of Pharmacy of Laval University. As a regular member, she is also part of the Centre for Advanced Materials Research (CAMaR), as well as the Centre Québécois on Functional Materials (CQMF). Her research interests focus on a better understanding of the structures and functions of skin tissue through advanced models of tissue reconstruction. Her team recently developed an immunocompetent psoriatic skin replacement model reconstructed from human cells, a major breakthrough in this area.

Dr. Pouliot is the recipient of Laval University’s 2016 Graduate Teaching and Coaching Award.

Understanding the complexity of structures and functions of skin tissue

In vitro skin diffusion tests are one of the first steps in the development of a transdermal drug. To this end, a robust model of cutaneous biomaterial is necessary for the precise study of the diffusion mechanisms of therapeutic molecules. Advanced lipidomic characterization of tissue-engineered samples is essential for understanding the skin lipid domain, which is complex and poorly reproduced in vitro. However, the biomimetic quality currently developed within our research team allows us to consider improving the models to obtain the qualities found within a native skin, whether healthy or pathological.

Modelling psoriasis and developing new pharmacological strategies

Cutaneous diseases such as psoriasis are complex diseases whose development and persistence involve several cellular processes and cell types. In recent years, our research team has developed a world-unique model of reconstructed psoriatic skin. Through tissue engineering, it becomes possible to reconstruct, according to the self-assembly method, a completely autologous pathological skin, that is to say without exogenous material, and composed of both a dermis and an epidermis. This model of pathological skin provides us with the opportunity to study separately the players involved in the development of psoriasis, and therefore becomes a powerful tool in the mechanistic analysis of this complex pathology. Distinctly, the latter is three-dimensional, designed from psoriatic human cells, in addition to developing in a highly physiological environment.

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Québec, Québec
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Simard M, Morin S, Ridha Z, Pouliot R

Current knowledge of the implication of lipid mediators in psoriasis

Journal Article

Front Immunol, 13 , 2022.

Abstract | Links:

Rioux G, Turgeon F, Le-Bel G, Grenier C, Guérin SL, Pouliot R

Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling

Journal Article

Cells, 11 (18), 2022.

Abstract | Links:

Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils

Journal Article

Cells, 10 (9), 2021.

Abstract | Links:

Tinto F, Archambault AS, Dumais É, Rakotoarivelo V, Kostrzewa M, Martin C, Plante PL, Desjardins Y, Simard M, Pouliot R, De Petrocellis L, Ligresti A, Di Marzo V, Flamand N

Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva

Journal Article

Biochim Biophys Acta Mol Cell Biol Lipids, 1866 (8), 2021.

Abstract | Links:

Simard M, Rioux G, Morin S, Martin C, Guérin SL, Flamand N, Julien P, Fradette J, Pouliot R

Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells

Journal Article

J Invest Dermatol, 141 (10), 2021.

Abstract | Links:

Morin S, Simard M, Flamand N, Pouliot R

Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway

Journal Article

Biochim Biophys Acta Mol Cell Biol Lipids, 1866 (12), 2021.

Abstract | Links:

Grenier A, Legault J, Pichette A, Jean L, Bélanger A, Pouliot R

Antioxidant, Anti-Inflammatory, and Anti-Aging Potential of a Kalmia angustifolia Extract and Identification of Some Major Compounds

Journal Article

Antioxidants (Basel), 10 (9), 2021.

| Links:

Tremblay A, Simard M, Morin S, Pouliot R

Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model

Journal Article

Int J Mol Sci, 22 (23), 2021.

Abstract | Links:

Rioux G, Simard M, Morin S, Lorthois I, Guérin SL, Pouliot R

Development of a 3D psoriatic skin model optimized for infiltration of IL-17A producing T cells: Focus on the crosstalk between T cells and psoriatic keratinocytes

Journal Article

Acta Biomater, 136 , 2021.

Abstract | Links:

Rioux G, Ridha Z, Simard M, Turgeon F, Guerin SL, Pouliot R

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis

Journal Article

Genes (Basel), 11 (10), 2020.

Abstract | Links:

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Active projects

  • A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies, from 2024-04-01 to 2029-03-31
  • Breaking barriers in drug delivery via using viscoplastic fluids for precise control of jet evolution and penetration, from 2024-03-31 to 2026-03-30
  • Centre Québécois sur les Matériaux Fonctionnels, from 2024-04-01 to 2030-03-31
  • Comprendre la complexité du domaine lipidique cutané, from 2019-04-01 to 2027-03-31
  • Nouvelles options thérapeutiques pour les patients atteints de psoriasis, from 2019-10-01 to 2024-09-30

Recently finished projects

  • Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
  • Étude de l'impact de l'innervation cutanée dans le Psoriasis, from 2018-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery