Dr. Roxane Pouliot is a regular researcher at the CHU Research Centre of Quebec-Laval University, and Professor at the Faculty of Pharmacy of Laval University. As a regular member, she is also part of the Centre for Advanced Materials Research (CAMaR), as well as the Centre Québécois on Functional Materials (CQMF). Her research interests focus on a better understanding of the structures and functions of skin tissue through advanced models of tissue reconstruction. Her team recently developed an immunocompetent psoriatic skin replacement model reconstructed from human cells, a major breakthrough in this area.
Dr. Pouliot is the recipient of Laval University’s 2016 Graduate Teaching and Coaching Award.
Understanding the complexity of structures and functions of skin tissue
In vitro skin diffusion tests are one of the first steps in the development of a transdermal drug. To this end, a robust model of cutaneous biomaterial is necessary for the precise study of the diffusion mechanisms of therapeutic molecules. Advanced lipidomic characterization of tissue-engineered samples is essential for understanding the skin lipid domain, which is complex and poorly reproduced in vitro. However, the biomimetic quality currently developed within our research team allows us to consider improving the models to obtain the qualities found within a native skin, whether healthy or pathological.
Modelling psoriasis and developing new pharmacological strategies
Cutaneous diseases such as psoriasis are complex diseases whose development and persistence involve several cellular processes and cell types. In recent years, our research team has developed a world-unique model of reconstructed psoriatic skin. Through tissue engineering, it becomes possible to reconstruct, according to the self-assembly method, a completely autologous pathological skin, that is to say without exogenous material, and composed of both a dermis and an epidermis. This model of pathological skin provides us with the opportunity to study separately the players involved in the development of psoriasis, and therefore becomes a powerful tool in the mechanistic analysis of this complex pathology. Distinctly, the latter is three-dimensional, designed from psoriatic human cells, in addition to developing in a highly physiological environment.
CMDGT / LOEX
R-207
Québec, Québec
Canada G1J 1Z4
- Bélanger, SarahMaster studentsarah.belanger@crchudequebec.ulaval.ca
- Grenier, CamilleMaster student+1 418-525-4444, extension 15412camille.grenier@crchudequebec.ulaval.ca
- Lang, JolaineEmployeejolaine.lang@crchudequebec.ulaval.ca
- Lavoie-Pelletier, Marie-HélèneEmployeemarie-helene.lavoie-pelletier@crchudequebec.ulaval.ca
- Matthey-De-l'Endroit, JustineMaster studentHôpital de l'Enfant-Jésusjustine.matthey-de-lendroit@crchudequebec.ulaval.ca
1401 18e Rue
Québec, QC
Canada G1J 1Z4 - Morin, SophieDoctoral studentsophie.morin.7@ulaval.casophie.morin@crchudequebec.ulaval.ca
- Ruel, YasmineDoctoral studentHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61671yasmine.ruel@crchudequebec.ulaval.ca
1401 18e Rue
R-207
Québec, QC
Canada G1J 1Z4 - Tremblay, AndréaDoctoral studentandrea.tremblay@crchudequebec.ulaval.ca
- Turgeon, FlorenceMaster studentHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61717florence.turgeon@crchudequebec.ulaval.ca
1401, 18e rue
R-229
Québec, QC
Canada G1J 1Z4 - Turpin-Langlois, LaurenceEmployeelaurence.turpin-langlois@crchudequebec.ulaval.ca
Toxic Interaction Between Solar Radiation and Cigarette Smoke on Primary Human Keratinocytes
Journal ArticlePhotochem Photobiol, 2022.
Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling
Journal ArticleCells, 11 (18), 2022.
Current knowledge of the implication of lipid mediators in psoriasis
Journal ArticleFront Immunol, 13 , 2022.
Antipsoriatic Potential of Quebecol and Its Derivatives
Journal ArticlePharmaceutics, 14 (6), 2022.
Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids
Journal ArticleBiomedicines, 10 (5), 2022.
Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model
Journal ArticleCells, 11 (9), 2022.
α-Linolenic acid and linoleic acid modulate the lipidome and the skin barrier of a tissue-engineered skin model
Journal ArticleActa Biomater, 140 , 2022.
Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model
Journal ArticleInt J Mol Sci, 22 (23), 2021.
Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites -13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils
Journal ArticleCells, 10 (9), 2021.
Development of a 3D psoriatic skin model optimized for infiltration of IL-17A producing T cells: Focus on the crosstalk between T cells and psoriatic keratinocytes
Journal ArticleActa Biomater, 136 , 2021.
Active projects
- Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
- Comprendre la complexité du domaine lipidique cutané, from 2019-04-01 to 2024-03-31
- Étude de l'impact de l'innervation cutanée dans le Psoriasis, from 2018-04-01 to 2023-03-31
- Nouvelles options thérapeutiques pour les patients atteints de psoriasis, from 2019-10-01 to 2024-09-30
Recently finished projects
- Évaluation de l’impact d’un ingrédient cosméceutique de source marine (Aldavine) sur le psoriasis, par le biais du génie tissulaire, from 2020-08-30 to 2021-03-31
- L’influence de la supplémentation en oméga-3 et en oméga-6 sur la fonction barrière des substituts cutanés produits par génie tissulaire, from 2020-08-30 to 2021-03-31