Robert Viger, PhD, is a researcher and regular member of the Centre de recherche du CHU de Québec-Laval University, and Professor in the Department of Obstetrics, Gynecology, and Reproduction at the Laval University School of Medicine. At Laval University, Professor Viger has also been Scientific Director of the Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), since 2014. His laboratory is presently investigating the molecular and genetic pathways involved in early gonadal differentiation, the regulation of gonad-specific gene expression, and the control of gonadal physiology. His research has been continuously funded by the Canadian Institutes of Health Research (CIHR), since 1998. From 2002 to 2012, he held the Tier 2 Canada Research Chair in Reproduction and Sex Development.

Understanding, preventing, and treating problems related to reproductive health

Reproductive dysfunction is a common medical condition. Problems range from differences in the sex determination and differentiation pathways to male and female infertility. Research in these areas is therefore essential to better understand, diagnose, treat, and hopefully prevent these problems that can be devastating for many individuals and couples. His laboratory seeks to understand the molecular and genetic mechanisms involved in human and animal reproduction in both health and disease. His goal is to provide the necessary groundwork for developing novel therapies that can eventually be used to improve reproductive health, and therefore the quality of life of those affected.

His laboratory is specifically interested in defining the transcriptional regulatory pathways that are involved in establishing mammalian sex determination (i.e., the formation of a testis or an ovary) and sex differentiation (i.e., the development of internal and external genitalia, and therefore the male or female phenotype). Over the past several years, his research has also brought new insights into our understanding of several pathologies that affect women’s health such as breast cancer, endometriosis, and polycystic ovary syndrome.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
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Nenonene EK, Karen Nenonene E, Trottier-Lavoie M, Marchais M, Bastien A, Gilbert I, Macaulay AD, Khandjian EW, Maria Luciano A, Lodde V, Viger R, Viger RS, Robert C

Roles of the cumulus-oocyte transzonal network and the Fragile X protein family in oocyte competence

Journal Article

Reproduction, 165 (2), 2023.

Abstract | Links:

Bouchard MF, Picard J, Tremblay JJ, Viger RS

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis

Journal Article

Int J Mol Sci, 23 (19), 2022.

Abstract | Links:

Mehanovic S, Pierre KJ, Viger RS, Tremblay JJ

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells

Journal Article

Andrology, 10 (7), 2022.

Abstract | Links:

Viger RS, de Mattos K, Tremblay JJ

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression

Journal Article

Front Endocrinol (Lausanne), 13 , 2022.

Abstract | Links:

de Mattos K, Viger RS, Tremblay JJ

Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function

Journal Article

Front Endocrinol (Lausanne), 13 , 2022.

Abstract | Links:

Bélanger C, Cardinal T, Leduc E, Viger RS, Pilon N

CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms

Journal Article

FASEB J, 36 (3), 2022.

Abstract | Links:

Haque E, Śmiech M, Łuczyńska K, Bouchard MF, Viger R, Kono H, Pierzchała M, Taniguchi H

NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines

Journal Article

Int J Mol Sci, 22 (10), 2021.

Abstract | Links:

Mehanovic S, Mendoza-Villarroel RE, de Mattos K, Talbot P, Viger RS, Tremblay JJ

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†

Journal Article

Biol Reprod, 105 (5), 2021.

Abstract | Links:

Leszczyński P, Śmiech M, Salam Teeli A, Haque E, Viger R, Ogawa H, Pierzchała M, Taniguchi H

Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells

Journal Article

Int J Mol Sci, 21 (19), 2020.

Abstract | Links:

Mehanovic S, Mendoza-Villarroel RE, Viger RS, Tremblay JJ

The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells

Journal Article

J Endocr Soc, 3 (12), 2019.

Abstract | Links:

13 entries « 1 of 2 »
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Active projects

  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2023-03-31
  • Rôle du facteur de transcription GATA4 dans la différenciation sexuelle masculine, from 2022-07-01 to 2023-06-30
  • Sex, hormones, and fertility: elucidating the molecular mechanism of action of transcription factor GATA4 in reproductive function, from 2019-10-01 to 2024-09-30

Recently finished projects

  • Importance des protéines reliées au syndrome X-Fragile dans les fonctions reproductives masculines, from 2020-12-16 to 2021-12-31
Data provided by the Université Laval research projects registery