Robert Viger, PhD, is a researcher and regular member of the Centre de recherche du CHU de Québec-Laval University, and Professor in the Department of Obstetrics, Gynecology, and Reproduction at the Laval University School of Medicine. At Laval University, Professor Viger has also been Scientific Director of the Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), since 2014. His laboratory is presently investigating the molecular and genetic pathways involved in early gonadal differentiation, the regulation of gonad-specific gene expression, and the control of gonadal physiology. His research has been continuously funded by the Canadian Institutes of Health Research (CIHR), since 1998. From 2002 to 2012, he held the Tier 2 Canada Research Chair in Reproduction and Sex Development.

Understanding, preventing, and treating problems related to reproductive health

Reproductive dysfunction is a common medical condition. Problems range from differences in the sex determination and differentiation pathways to male and female infertility. Research in these areas is therefore essential to better understand, diagnose, treat, and hopefully prevent these problems that can be devastating for many individuals and couples. His laboratory seeks to understand the molecular and genetic mechanisms involved in human and animal reproduction in both health and disease. His goal is to provide the necessary groundwork for developing novel therapies that can eventually be used to improve reproductive health, and therefore the quality of life of those affected.

His laboratory is specifically interested in defining the transcriptional regulatory pathways that are involved in establishing mammalian sex determination (i.e., the formation of a testis or an ovary) and sex differentiation (i.e., the development of internal and external genitalia, and therefore the male or female phenotype). Over the past several years, his research has also brought new insights into our understanding of several pathologies that affect women’s health such as breast cancer, endometriosis, and polycystic ovary syndrome.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
49 entries « 1 of 5 »

Dubuc K, Marchais M, Gilbert I, Bastien A, Nenonene KE, Khandjian EW, Viger RS, Delbes G, Robert C

Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles

Journal Article

J Ovarian Res, 16 (1), 2023.

Abstract | Links:

de Mattos K, Dumas FO, Campolina-Silva GH, Belleannée C, Viger RS, Tremblay JJ

ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells

Journal Article

Endocrinology, 164 (9), 2023.

Abstract | Links:

Nenonene EK, Karen Nenonene E, Trottier-Lavoie M, Marchais M, Bastien A, Gilbert I, Macaulay AD, Khandjian EW, Maria Luciano A, Lodde V, Viger RS, Robert C

Roles of the cumulus-oocyte transzonal network and the Fragile X protein family in oocyte competence

Journal Article

Reproduction, 165 (2), 2023.

Abstract | Links:

Bélanger C, Cardinal T, Leduc E, Viger RS, Pilon N

CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms

Journal Article

FASEB J, 36 (3), 2022.

Abstract | Links:

de Mattos K, Viger RS, Tremblay JJ

Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function

Journal Article

Front Endocrinol (Lausanne), 13 , 2022.

Abstract | Links:

Viger RS, de Mattos K, Tremblay JJ

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression

Journal Article

Front Endocrinol (Lausanne), 13 , 2022.

Abstract | Links:

Bouchard MF, Picard J, Tremblay JJ, Viger RS

A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis

Journal Article

Int J Mol Sci, 23 (19), 2022.

Abstract | Links:

Mehanovic S, Pierre KJ, Viger RS, Tremblay JJ

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti-Müllerian hormone receptor type 2 transcription in mouse MA-10 Leydig cells

Journal Article

Andrology, 10 (7), 2022.

Abstract | Links:

Haque E, Śmiech M, Łuczyńska K, Bouchard MF, Viger R, Kono H, Pierzchała M, Taniguchi H

NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines

Journal Article

Int J Mol Sci, 22 (10), 2021.

Abstract | Links:

Mehanovic S, Mendoza-Villarroel RE, de Mattos K, Talbot P, Viger RS, Tremblay JJ

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†

Journal Article

Biol Reprod, 105 (5), 2021.

Abstract | Links:

49 entries « 1 of 5 »
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Active projects

  • Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models, from 2023-04-01 to 2028-03-31
  • Réseau Québécois en Reproduction, from 2024-04-01 to 2030-03-31
  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2025-03-31
  • Sex, hormones, and fertility: elucidating the molecular mechanism of action of transcription factor GATA4 in reproductive function, from 2019-10-01 to 2024-09-30

Recently finished projects

  • Rôle du facteur de transcription GATA4 dans la différenciation sexuelle masculine, from 2022-07-01 to 2023-06-30
Data provided by the Université Laval research projects registery