Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
2705, boulevard Laurier
Canada G1V 4G2
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Human vascular endothelial cells with extended life spans: in vitro cell response, protein expression, and angiogenesisJournal Article
Angiogenesis, 5 (1-2), 2002.
Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrestJournal Article
Free Radic Biol Med, 33 (9), 2002.
Checkpoints for vesicular traffic?Journal Article
Biochem Cell Biol, 79 (5), 2001.
Characterization of Cdk2-cyclin E complexes in plasma membrane and endosomes of liver parenchyma. Insulin-dependent regulationJournal Article
J Biol Chem, 275 (22), 2000.
Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cellsJournal Article
Exp Cell Res, 256 (2), 2000.
Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxideJournal Article
Eur J Immunol, 30 (9), 2000.
Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscleJournal Article
Diabetes, 49 (11), 2000.
Vacuolar system-associated protein-60: a protein characterized from bovine granulosa and luteal cells that is associated with intracellular vesicles and related to human 80K-H and murine beta-glucosidase IIJournal Article
Biol Reprod, 62 (3), 2000.
Compartmentalization of the mitogen-activated protein kinase (MAPK) in hepatic endosomes: association with the internalized epidermal growth factor (EGF) receptorJournal Article
Mol Cell Biol Res Commun, 1 (2), 1999.
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activationJournal Article
Eur J Immunol, 29 (11), 1999.