Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.

Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 48263+1 418-654-2783
robert.faure@crchudequebe...

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Gagnon E, Cattaruzzi P, Griffith M, Muzakare L, LeFlao K, Faure R, Béliveau R, Hussain SN, Koutsilieris M, Doillon CJ

Human vascular endothelial cells with extended life spans: in vitro cell response, protein expression, and angiogenesis

Journal Article

Angiogenesis, 5 (1-2), 2002.

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Bilodeau JF, Patenaude A, Piedboeuf B, Carrier C, Petrov P, Faure R, Mirault ME

Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest

Journal Article

Free Radic Biol Med, 33 (9), 2002.

Abstract | Links:

Fiset A, Faure R

Checkpoints for vesicular traffic?

Journal Article

Biochem Cell Biol, 79 (5), 2001.

Abstract | Links:

Brûlé S, Rabahi F, Faure R, Beckers JF, Silversides DW, Lussier JG

Vacuolar system-associated protein-60: a protein characterized from bovine granulosa and luteal cells that is associated with intracellular vesicles and related to human 80K-H and murine beta-glucosidase II

Journal Article

Biol Reprod, 62 (3), 2000.

Abstract | Links:

Dombrowski L, Faure R, Marette A

Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle

Journal Article

Diabetes, 49 (11), 2000.

Abstract | Links:

Matte C, Marquis JF, Blanchette J, Gros P, Faure R, Posner BI, Olivier M

Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxide

Journal Article

Eur J Immunol, 30 (9), 2000.

Abstract | Links:

Bilodeau JF, Faure R, Piedboeuf B, Mirault ME

Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cells

Journal Article

Exp Cell Res, 256 (2), 2000.

Abstract | Links:

Gaulin JF, Fiset A, Fortier S, Faure RL

Characterization of Cdk2-cyclin E complexes in plasma membrane and endosomes of liver parenchyma. Insulin-dependent regulation

Journal Article

J Biol Chem, 275 (22), 2000.

Abstract | Links:

Blanchette J, Racette N, Faure R, Siminovitch KA, Olivier M

Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation

Journal Article

Eur J Immunol, 29 (11), 1999.

Abstract | Links:

Faure R, Gaulin JF, Bourgoin S, Fortier S

Compartmentalization of the mitogen-activated protein kinase (MAPK) in hepatic endosomes: association with the internalized epidermal growth factor (EGF) receptor

Journal Article

Mol Cell Biol Res Commun, 1 (2), 1999.

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39 entries « ‹ 3 of 4 › »
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