Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
2705, boulevard Laurier
Canada G1V 4G2
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Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexesJournal Article
J Proteome Res, 9 (2), 2010.
Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: lessons to be learned from the adenovirus E4orf4 death factorJournal Article
Cell Signal, 22 (11), 2010.
Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulatedJournal Article
J Proteome Res, 7 (10), 2008.
Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cellsJournal Article
Cancer Lett, 262 (2), 2008.
Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-SrcJournal Article
FEBS J, 273 (5), 2006.
Identification of the proteins present in the bull sperm cytosolic fraction enriched in tyrosine kinase activity: a proteomic approachJournal Article
Proteomics, 6 (16), 2006.
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasisJournal Article
Nat Med, 12 (5), 2006.
A novel mutation in the EIF2AK3 gene with variable expressivity in two patients with Wolcott-Rallison syndromeJournal Article
Clin Genet, 70 (1), 2006.
Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCKJournal Article
Mol Reprod Dev, 73 (4), 2006.
Immunolocalization of vacuolar system-associated protein-60 (VASAP-60)Journal Article
Histochem Cell Biol, 119 (5), 2003.