Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
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Network medicine-travelling with the insulin receptor: Encounter of the second typeJournal Article
EClinicalMedicine, 13 , 2019.
A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomesJournal Article
PLoS One, 13 (10), 2018.
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein networkJournal Article
Mol Cell Proteomics, 14 (4), 2015.
Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulinJournal Article
FEBS Lett, 589 (9), 2015.
Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomasJournal Article
Future Oncol, 9 (8), 2013.
Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signalingJournal Article
Exp Cell Res, 319 (4), 2013.
Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlationJournal Article
Cell Signal, 25 (10), 2013.
Proteomic analysis identifies new biomarkers for postmenopausal and dry skinJournal Article
Exp Dermatol, 21 (3), 2012.
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalizationJournal Article
Cell Signal, 23 (5), 2011.
Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexesJournal Article
J Proteome Res, 9 (2), 2010.