Dr. Laforce obtained his PhD in Clinical Neuropsychology in 1998 and worked as an Assistant Professor in Cognitive Neurosciences before completing his studies in Behavioral Neurology in 2011. He performed a short Fellowship in frontotemporal dementia under Dr. Bruce Miller at the Memory and Aging Center, University of California San Francisco. He conducted brain imaging studies using FDG-PET and amyloid PET with Dr. Gil Rabinovici (University of California, Berkeley). He was co-leader of the Neurology class at Laval University for 5 years. He is a Clinician and Researcher in CHU de Québec Research Center, member of the C5R (Consortium of Canadian Centres for Clinical Cognitive Research) and RQRV (Réseau Québécois de Recherche sur le Vieillissement). Dr. Laforce obtained several major grants (CIHR, Weston Brain Institute), presented at national and international meetings, published over 100 scientific papers in prestigious journals such as Lancet Neurology, Brain, Neurology. He wrote a book on memory as well as several book chapters. Dr. Laforce is one of the PIs in the great international endeavour GENFI (Genetic Frontotemporal Dementia Initiative) and DIAN (Dominantly Inherited Alzheimer Network). He leads several research projects on the development of cognitive tools (www.dcqtest.org et www.quoco.org) and the clinical utility of molecular imaging such as FDG-PET and amyloid PET in the differential diagnosis of atypical dementias. He holds the Chaire de Recherche sur les Aphasies Primaires Progressives – Fondation Famille Lemaire (https://app-ffl.ulaval.ca/).
Clinique Interdisciplinaire de Mémoire
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Québec, Québec
Canada G1J 1Z4
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Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort
Journal ArticleBrain Commun, 5 (2), 2023.
Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia
Journal ArticleBrain Commun, 5 (2), 2023.
Early neurotransmitters changes in prodromal frontotemporal dementia: A GENFI study
Journal ArticleNeurobiol Dis, 179 , 2023.
Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
Journal ArticleHum Brain Mapp, 44 (7), 2023.
The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study
Journal ArticleJ Neurol Sci, 446 , 2023.
Development and validation of the Montreal cognitive assessment for people with hearing impairment (MoCA-H)
Journal ArticleJ Am Geriatr Soc, 71 (5), 2023.
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease
Journal ArticleJ Cereb Blood Flow Metab, 43 (6), 2023.
Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
Journal ArticleJ Neurol Neurosurg Psychiatry, 94 (5), 2023.
Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Journal ArticleJ Neurol, 270 (4), 2023.
Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study
Journal ArticleJ Neurol, 270 (3), 2023.
Active projects
- Chaire de recherche sur les aphasies primaires progressives, from 2019-07-01 to 2024-06-30
- DIAN-TU : A Phase II/III Randomized, Double-Blind, Placebo-Controlled, Cognitive Endpoint, Multicenter Study of Potential Disease Modifying Therapies in Individuals at Risk for and with Dominantly Inherited Alzheimer’s Disease, from 2020-06-01 to 2024-05-31
- Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers, from 2021-04-01 to 2026-03-31
- Phase Two of the Canadian Consortium on Neurodegeneration in Aging, from 2019-04-01 to 2024-03-31
Recently finished projects
- Caractérisation en TEP-18FDG du substrat neuro-fonctionnel de la dépression résistante du sujet âgé, from 2020-09-15 to 2022-04-30
- Création et gestion d'une banque de données formée de participants intéressés à participer aux projets de recherche de la Clinique de la mémoire, from 2020-09-02 to 2021-09-01
- Étude de l’histoire naturelle des aphasies primaires progressives, from 2020-09-15 to 2022-04-30