Dr. Laforce obtained his PhD in Clinical Neuropsychology in 1998 and worked as an Assistant Professor in Cognitive Neurosciences before completing his studies in Behavioral Neurology in 2011. He performed a short Fellowship in frontotemporal dementia under Dr. Bruce Miller at the Memory and Aging Center, University of California San Francisco. He conducted brain imaging studies using FDG-PET and amyloid PET with Dr. Gil Rabinovici (University of California, Berkeley). He was co-leader of the Neurology class at Laval University for 5 years. He is a Clinician and Researcher in CHU de Québec Research Center, member of the C5R (Consortium of Canadian Centres for Clinical Cognitive Research) and RQRV (Réseau Québécois de Recherche sur le Vieillissement). Dr. Laforce obtained several major grants (CIHR, Weston Brain Institute), presented at national and international meetings, published over 100 scientific papers in prestigious journals such as Lancet Neurology, Brain, Neurology. He wrote a book on memory as well as several book chapters. Dr. Laforce is one of the PIs in the great international endeavour GENFI (Genetic Frontotemporal Dementia Initiative) and DIAN (Dominantly Inherited Alzheimer Network). He leads several research projects on the development of cognitive tools (www.dcqtest.org et www.quoco.org) and the clinical utility of molecular imaging such as FDG-PET and amyloid PET in the differential diagnosis of atypical dementias. He holds the Chaire de Recherche sur les Aphasies Primaires Progressives – Fondation Famille Lemaire (https://app-ffl.ulaval.ca/).
Clinique Interdisciplinaire de Mémoire
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Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease
Journal ArticleJ Cereb Blood Flow Metab, 2023.
Neuropsychiatric symptoms in genetic frontotemporal dementia: developing a new module for Clinical Rating Scales
Journal ArticleJ Neurol Neurosurg Psychiatry, 2023.
It's all about cognitive trajectory: Accuracy of the cognitive charts-MoCA in normal aging, MCI, and dementia
Journal ArticleJ Am Geriatr Soc, 71 (1), 2023.
Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia
Journal ArticleBrain, 146 (1), 2023.
Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Journal ArticleJ Neurol, 2022.
Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study
Journal ArticleJ Neurol, 2022.
Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers
Journal ArticleBrain, 2022.
Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia
Journal ArticleAlzheimers Dement, 2022.
Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales
Journal ArticleJ Neurol, 2022.
Cognitive differences between healthy monolingual and bilingual anglophones on the English version of the Depistage Cognitif de Quebec: A new screening tool for atypical dementia
Journal ArticleInt J Billing, 2022.
Active projects
- Chaire de recherche sur les aphasies primaires progressives, from 2019-07-01 to 2024-06-30
- DIAN-TU : A Phase II/III Randomized, Double-Blind, Placebo-Controlled, Cognitive Endpoint, Multicenter Study of Potential Disease Modifying Therapies in Individuals at Risk for and with Dominantly Inherited Alzheimer’s Disease, from 2020-06-01 to 2024-05-31
- Phase Two of the Canadian Consortium on Neurodegeneration in Aging, from 2019-04-01 to 2024-03-31
Recently finished projects
- Caractérisation en TEP-18FDG du substrat neuro-fonctionnel de la dépression résistante du sujet âgé, from 2020-09-15 to 2022-04-30
- Création et gestion d'une banque de données formée de participants intéressés à participer aux projets de recherche de la Clinique de la mémoire, from 2020-09-02 to 2021-09-01
- Étude de l’histoire naturelle des aphasies primaires progressives, from 2020-09-15 to 2022-04-30
- Projet de recherche sur le diagnostic différentiel de la variante frontale de la maladie d'Alzheimer et la variante comportementale de la démence frontotemporelle , from 2020-05-07 to 2021-05-06