Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

L'Hôtel-Dieu de Québec
9, rue McMahon
Québec, Québec
Canada G1R 2J6

Adjibade P, Mazroui R

Stress granules: stress-induced cytoplasmic mRNPs compartments linked to mRNA translational regulatory pathways

Journal Article

Front. RNA res., 1 , 2023.

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Ledoux N, Gauthier-Naud W, Lavoie O, Watters V, Hussein S, Adjibade P, Mazroui R

The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges

Journal Article

Mol Biol Cell, 34 (5), 2023.

Abstract | Links:

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Active projects

  • FGR - Role of the RNA-binding protein FMRP in DNA damage signaling, from 2023-05-18 to 2024-05-17

Recently finished projects

  • Role of DDX3-ALKBH5 interaction in ATF4 mRNA translation: implications in chemoresistance, from 2021-09-01 to 2023-08-31
  • Role of FXR proteins in the cell stress response., from 2015-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery