Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.
9, rue McMahon
0734-3
Québec, Québec
Canada G1R 2J6
- Adjibade, PaulinePostdoctoral fellowL'Hôtel-Dieu de Québec+1 418-525-4444, extension 15586+1 418-525-4195pauline.adjibade.1@ulaval.capauline.adjibade@crchudequebec.ulaval.ca
9, rue McMahon
0734-3
Québec, Québec
Canada G1R 2J6 - Gauthier-Naud, WilliamMaster studentL'Hôtel-Dieu de Québec+1 418-525-4444, extension 15553william.gauthier-naud.1@ulaval.cawilliam.gauthier-naud@crchudequebec.ulaval.ca
9 Rue Mcmahon
0734
Québec, QC
Canada G1R 2J6 - Ledoux, NassimDoctoral studentL'Hôtel-Dieu de Québecnassim.ledoux.1@ulaval.canassim.ledoux@crchudequebec.ulaval.ca
9 Rue Mcmahon
Québec, QC
Canada G1R 3S3 - Lelong, EmelineDoctoral studentEmeline.Lelong@crchudequebec.ulaval.ca
Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation
Journal ArticleNAR Cancer, 4 (4), 2022.
The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans
Journal ArticlePLoS Genet, 17 (4), 2021.
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation
Journal ArticlePLoS One, 15 (5), 2020.
PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation
Journal ArticleMol Biol Cell, 30 (6), 2019.
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression
Journal ArticleSci Rep, 7 (1), 2017.
Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq
Journal ArticleJ Biol Methods, 3 (4), 2016.
The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein
Journal ArticleNutrients, 8 (9), 2016.
Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells
Journal ArticleOncotarget, 6 (41), 2015.
Localized control of oxidized RNA
Journal ArticleJ Cell Sci, 128 (22), 2015.
Analysis of translation initiation during stress conditions by polysome profiling
Journal ArticleJ Vis Exp, (87), 2014.
Active projects
- Role of DDX3-ALKBH5 interaction in ATF4 mRNA translation: implications in chemoresistance, from 2021-09-01 to 2023-08-31
- Role of FXR proteins in the cell stress response., from 2015-04-01 to 2023-03-31
Recently finished projects
- Defining the role of stress granules (SG) in RNA stability and translation, from 2020-03-31 to 2021-03-31