Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

L'Hôtel-Dieu de Québec
9, rue McMahon
0734-3
Québec, Québec
Canada G1R 2J6
40 entries « 1 of 4 »

Adjibade P, Mazroui R

Stress granules: stress-induced cytoplasmic mRNPs compartments linked to mRNA translational regulatory pathways

Journal Article

Front. RNA res., 1 , 2023.

| Links:

Ledoux N, Gauthier-Naud W, Lavoie O, Watters V, Hussein S, Adjibade P, Mazroui R

The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges

Journal Article

Mol Biol Cell, 34 (5), 2023.

Abstract | Links:

Ledoux N, Lelong EIJ, Simard A, Hussein S, Adjibade P, Lambert JP, Mazroui R

The Identification of Nuclear FMRP Isoform Iso6 Partners

Journal Article

Cells, 12 (24), 2023.

Abstract | Links:

Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

Journal Article

NAR Cancer, 4 (4), 2022.

Abstract | Links:

Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

Journal Article

PLoS One, 15 (5), 2020.

Abstract | Links:

Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Cote J

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation

Journal Article

Mol Biol Cell, 30 (6), 2019.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression

Journal Article

Sci Rep, 7 (1), 2017.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Droit A, Khandjian EW, Toren P, Mazroui R

Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq

Journal Article

J Biol Methods, 3 (4), 2016.

Abstract | Links:

Marquez-Mota CC, Rodriguez-Gaytan C, Adjibade P, Mazroui R, Galvez A, Granados O, Tovar AR, Torres N

The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein

Journal Article

Nutrients, 8 (9), 2016.

Abstract | Links:

40 entries « 1 of 4 »
Signaler des ajouts ou des modifications

Active projects

  • FGR - Role of the RNA-binding protein FMRP in DNA damage signaling, from 2023-05-18 to 2024-05-17

Recently finished projects

  • Role of DDX3-ALKBH5 interaction in ATF4 mRNA translation: implications in chemoresistance, from 2021-09-01 to 2023-08-31
  • Role of FXR proteins in the cell stress response., from 2015-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery