Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

L'Hôtel-Dieu de Québec
9, rue McMahon
0734-3
Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 15556
Rachid.Mazroui@crchudeque... rachid.mazroui@fmed.ulava...

Latest news

37 entries « ‹ 1 of 4 › »

Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation

Journal Article

NAR Cancer, 4 (4), 2022.

Abstract | Links:

Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

Journal Article

PLoS One, 15 (5), 2020.

Abstract | Links:

Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Cote J

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation

Journal Article

Mol Biol Cell, 30 (6), 2019.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression

Journal Article

Sci Rep, 7 (1), 2017.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Droit A, Khandjian EW, Toren P, Mazroui R

Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq

Journal Article

J Biol Methods, 3 (4), 2016.

Abstract | Links:

Marquez-Mota CC, Rodriguez-Gaytan C, Adjibade P, Mazroui R, Galvez A, Granados O, Tovar AR, Torres N

The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein

Journal Article

Nutrients, 8 (9), 2016.

Abstract | Links:

Adjibade P, St-Sauveur VG, Quevillon Huberdeau M, Fournier MJ, Savard A, Coudert L, Khandjian EW, Mazroui R

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells

Journal Article

Oncotarget, 6 (41), 2015.

Abstract | Links:

Zhan Y, Dhaliwal JS, Adjibade P, Uniacke J, Mazroui R, Zerges W

Localized control of oxidized RNA

Journal Article

J Cell Sci, 128 (22), 2015.

Abstract | Links:

Coudert L, Adjibade P, Mazroui R

Analysis of translation initiation during stress conditions by polysome profiling

Journal Article

J Vis Exp, (87), 2014.

Abstract | Links:

37 entries « ‹ 1 of 4 › »
Signaler des ajouts ou des modifications

Active projects

  • Role of DDX3-ALKBH5 interaction in ATF4 mRNA translation: implications in chemoresistance, from 2021-09-01 to 2023-08-31
  • Role of FXR proteins in the cell stress response., from 2015-04-01 to 2023-03-31

Recently finished projects

  • Defining the role of stress granules (SG) in RNA stability and translation, from 2020-03-31 to 2021-03-31
Data provided by the Université Laval research projects registery