Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.

Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.

His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.

About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.

CHUL
2705, boulevard Laurier
T3-56
Québec, Québec
Canada G1V 4G2
50 entries « 5 of 5 »

Laflamme J, Akoum A, Leclerc P

Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6

Journal Article

Mol Hum Reprod, 11 (2), 2005.

Abstract | Links:

Nauc V, De Lamirande E, Leclerc P, Gagnon C

Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences

Journal Article

J Androl, 25 (4), 2004.

Abstract | Links:

Boilard M, Reyes-Moreno C, Lachance C, Massicotte L, Bailey JL, Sirard MA, Leclerc P

Localization of the chaperone proteins GRP78 and HSP60 on the luminal surface of bovine oviduct epithelial cells and their association with spermatozoa

Journal Article

Biol Reprod, 71 (6), 2004.

Abstract | Links:

Lessard C, Masseau I, Bilodeau JF, Kroetsch T, Twagiramungu H, Bailey JL, Leclerc P, Sullivan R

Semen characteristics of genetically identical quadruplet bulls

Journal Article

Theriogenology, 59 (8), 2003.

Abstract | Links:

Huot ME, Mazroui R, Leclerc P, Khandjian EW

Developmental expression of the fragile X-related 1 proteins in mouse testis: association with microtubule elements

Journal Article

Hum Mol Genet, 10 (24), 2001.

Abstract | Links:

Lessard C, Parent S, Leclerc P, Bailey JL, Sullivan R

Cryopreservation alters the levels of the bull sperm surface protein P25b

Journal Article

J Androl, 21 (5), 2000.

Abstract | Links:

Leclerc P, Sirard MA, Chafouleas JG, Lambert RD

Decrease in calmodulin concentrations during heparin-induced capacitation in bovine spermatozoa

Journal Article

J Reprod Fertil, 94 (1), 1992.

Abstract | Links:

Leclerc P, Sirard MA, Chafouleas JG, Lambert RD

Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation

Journal Article

Biol Reprod, 42 (3), 1990.

Abstract | Links:

Leclerc P, Langlais J, Lambert RD, Sirard MA, Chafouleas JG

Effect of heparin on the expression of calmodulin-binding proteins in bull spermatozoa

Journal Article

J Reprod Fertil, 85 (2), 1989.

Abstract | Links:

King WA, Xu KP, Sirard MA, Greve T, Leclerc P, Lambert RD, Jacques P

Cytogenetic study of parthenogenetically activated bovine oocytes matured in vivo and in vitro

Journal Article

Gamete Res, 20 (3), 1988.

Abstract | Links:

50 entries « 5 of 5 »
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Active projects

  • Elucidating the intracellular mechanisms that regulate mammalian sperm fertilizing ability and motility, from 2021-04-01 to 2026-03-31
  • Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract, from 2022-10-01 to 2027-09-30
  • Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability, from 2021-10-01 to 2026-09-30
  • Réseau Québécois en Reproduction, from 2024-04-01 to 2030-03-31
  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2025-03-31

Recently finished projects

  • Importance de la protéine STAT3 dans la spermiogenèse, l’intégrité et la motilité des spermatozoïdes, from 2022-07-01 to 2023-12-31
Data provided by the Université Laval research projects registery