Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.

Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.

His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.

About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.

CHUL
2705, boulevard Laurier
T3-56
Québec, Québec
Canada G1V 4G2
50 entries « 3 of 5 »

Goupil S, La Salle S, Trasler JM, Bordeleau LJ, Leclerc P

Developmental expression of SRC-related tyrosine kinases in the mouse testis

Journal Article

J Androl, 32 (1), 2011.

Abstract | Links:

Lachance C, Fortier M, Thimon V, Sullivan R, Bailey JL, Leclerc P

Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa

Journal Article

Int J Androl, 33 (1), 2010.

Abstract | Links:

Morin G, Sullivan R, Laflamme I, Robert C, Leclerc P

SPAM1 isoforms from two tissue origins are differentially localized within ejaculated bull sperm membranes and have different roles during fertilization

Journal Article

Biol Reprod, 82 (2), 2010.

Abstract | Links:

D'Amours O, Frenette G, Fortier M, Leclerc P, Sullivan R

Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes

Journal Article

Reproduction, 139 (3), 2010.

Abstract | Links:

Frenette G, Leclerc P, D'amours O, Sullivan R

Estrogen sulfotransferase is highly expressed along the bovine epididymis and is secreted into the intraluminal environment

Journal Article

J Androl, 30 (5), 2009.

Abstract | Links:

Pons-Rejraji H, Bailey JL, Leclerc P

Cryopreservation affects bovine sperm intracellular parameters associated with capacitation and acrosome exocytosis

Journal Article

Reprod Fertil Dev, 21 (4), 2009.

Abstract | Links:

Pons-Rejraji H, Bailey JL, Leclerc P

Modulation of bovine sperm signalling pathways: correlation between intracellular parameters and sperm capacitation and acrosome exocytosis

Journal Article

Reprod Fertil Dev, 21 (4), 2009.

Abstract | Links:

Bordeleau LJ, Leclerc P

Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis

Journal Article

Mol Reprod Dev, 75 (5), 2008.

Abstract | Links:

Lawson C, Goupil S, Leclerc P

Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium

Journal Article

Biol Reprod, 79 (4), 2008.

Abstract | Links:

Carli C, Leclerc P, Metz CN, Akoum A

Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility

Journal Article

Fertil Steril, 88 (4 Suppl), 2007.

Abstract | Links:

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Active projects

  • Elucidating the intracellular mechanisms that regulate mammalian sperm fertilizing ability and motility, from 2021-04-01 to 2026-03-31
  • Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract, from 2022-10-01 to 2027-09-30
  • Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability, from 2021-10-01 to 2026-09-30
  • Réseau Québécois en Reproduction, from 2024-04-01 to 2030-03-31
  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2025-03-31

Recently finished projects

  • Importance de la protéine STAT3 dans la spermiogenèse, l’intégrité et la motilité des spermatozoïdes, from 2022-07-01 to 2023-12-31
Data provided by the Université Laval research projects registery