Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.

Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.

His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.

About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.

CHUL
2705, boulevard Laurier
T3-56
Québec, Québec
Canada G1V 4G2
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Salmon VM, Leclerc P, Bailey JL

Cholesterol-Loaded Cyclodextrin Increases the Cholesterol Content of Goat Sperm to Improve Cold and Osmotic Resistance and Maintain Sperm Function after Cryopreservation

Journal Article

Biol Reprod, 94 (4), 2016.

Abstract | Links:

Goupil S, Marechal L, El Hajj H, Tremblay ME, Richard FJ, Leclerc P

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa

Journal Article

PLoS One, 11 (8), 2016.

Abstract | Links:

Plante G, Therien I, Lachance C, Leclerc P, Fan J, Manjunath P

Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein in capacitation

Journal Article

Mol Hum Reprod, 20 (5), 2014.

Abstract | Links:

Lachance C, Goupil S, Leclerc P

Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity

Journal Article

J Cell Physiol, 228 (4), 2013.

Abstract | Links:

D'Amours O, Bordeleau LJ, Frenette G, Leclerc P, Blondin P, Sullivan R

Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations

Journal Article

Reproduction, 143 (6), 2012.

Abstract | Links:

Leduc K, Bourassa V, Asselin E, Leclerc P, Lafond J, Reyes-Moreno C

Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways

Journal Article

Biol Reprod, 86 (2), 2012.

Abstract | Links:

O'Flaherty C, de Lamirande E, Leclerc P, Lefievre L, Robaire B

In memoriam: Claude Gagnon, Ph.D., 1950-2012

Journal Article

Biol Reprod, 87 (2), 2012.

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D'Amours O, Frenette G, Bordeleau LJ, Allard N, Leclerc P, Blondin P, Sullivan R

Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine

Journal Article

Biol Reprod, 87 (4), 2012.

Abstract | Links:

Goupil S, La Salle S, Trasler JM, Bordeleau LJ, Leclerc P

Developmental expression of SRC-related tyrosine kinases in the mouse testis

Journal Article

J Androl, 32 (1), 2011.

Abstract | Links:

Lessard C, Siqueira LG, D'Amours O, Sullivan R, Leclerc P, Palmer C

Infertility in a beef bull due to a failure in the capacitation process

Journal Article

Theriogenology, 76 (5), 2011.

Abstract | Links:

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Active projects

  • Elucidating the intracellular mechanisms that regulate mammalian sperm fertilizing ability and motility, from 2021-04-01 to 2026-03-31
  • Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract, from 2022-10-01 to 2027-09-30
  • Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability, from 2021-10-01 to 2026-09-30
  • Réseau Québécois en Reproduction, from 2024-04-01 to 2030-03-31
  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2025-03-31

Recently finished projects

  • Importance de la protéine STAT3 dans la spermiogenèse, l’intégrité et la motilité des spermatozoïdes, from 2022-07-01 to 2023-12-31
Data provided by the Université Laval research projects registery